This study aims to improve the learning outcomes of elementary school science students by using interactive multimedia on human skeleton material. This interactive multimedia is a learning media product in the form of an interactive CD. Based on information obtained by researchers that the lack of enthusiasm of students in science subjects, because students do not have a real picture of how the material process is explained. Therefore, this media is very important to support the learning process of science. The method used in this study uses the Research and Development (R&D) method with the 4D model which has 4 stages of development namely define, design, development, and disseminate. The results of the use of interactive multimedia on students showed that the average pretest score was 57.33 while the average posttest score was 84.17. Based on N-Gain of 0.60 in the medium category and it can be said that the effectiveness of interactive multimedia as a learning medium is classified as effective. Based on these results, it can be concluded that there is an increase in science learning outcomes for students of SDN 034 Taraibangun class IV using interactive multimedia on human skeleton material.