This study specifically explored the challenges that hinder the attainment of secondary education curriculum objectives towards preparing students for industrialisation in Nyamagana District, Mwanza, Tanzania. The study employed a mixed research method under a convergent parallel design. A sample size of 119 was drawn from a population of 44,448 using both probability and non-probability sampling. The sample included 47 teachers, 64 students, 5 heads of schools, 1 ward education officer, 1 district education officer, and 1 school quality assurance. Questionnaires were used to collect data from students and teachers, while an interview guide was used in data collection from the heads of schools, the school quality assurance, the ward education officer, and the district education officer. The tools were obtained through a pilot study and the correlation coefficient of 0.81 demonstrated that the instruments were reliable for data collection. Quantitative data collected was coded using descriptive statistics with the help of Statistical Package for Social Science (SPSS), version 20, and then presented in tables, figures, frequencies and percentages. Qualitative data was analysed thematically and presented in narratives. The study found that the attainment of curriculum objectives in preparing students for industrialisation is hindered by inadequate use of ICT tools and computers, poor medium of instruction, inadequate teachers, and shortage of school infrastructure. Therefore, the study recommends that the government should reform the curriculum, strengthen the media of instruction, invest in science and technology, improve school infrastructure, and introduce entrepreneurship and technical subjects to secondary schools.