The article is devoted to determine the main directions and priorities for the development of the pharmaceutical sector of health care in Ukraine. It studies real political and socio-economic processes. The research of pharmaceutical sector determine a vital social role in providing medicines and medical devices to the population. In the article has been presented one of the key elements of ensuring the effective functioning of the health care system.The purpose of the article is to determine the theoretical principles and provide recommendations of ensuring legal and institutional mechanisms of quality medicines as part of the national security of citizens, society and the state in Ukraine.The novelty of the research can allow us to offer the legal and institutional ways of ensuring the national interests of quality medicines. The approaches to the provision of medical facilities with high quality drugs and national security are not previously used. We tried to interpret the phenomenon of increasing the socially effective system of drug circulation of state drug policy through the development state mechanisms of providing the conditions of health insurance, which will ensure the availability of proper using drugs in Ukraine.The theoretical method used in the study allow to consider the medicinal help as a social benefit that has a value terms. Comparative method permited to demonstrate the difference of applying medicinal help service or social care. We have applied a method of analysis which researched the whole medical care system.It was found that, the issues of forming a holistic system of health products sale are covered and the proper approaches to it are substantiated. The mechanisms for implementing the state policy of ensuring the rational use of medicines as a component of the relevant integrated mechanism have been identied. It has been proved that the rational use of medicines is an important component of a strategy for implementation of the state policy of providing the population with health products. It was noted that one of the mechanisms for creating conditions for a rational use of medicines is introduction of a formulary system, that is, a set of management techniques in healthcare, which would ensure the application of rational, organizationally and economically effective methods of health products supply and use. Attention is drawn to the fact that implementation of an effective integrated multilevel formulary system is by far the only and an uncontested means of ensuring the effectiveness and rational use of health products on clear and comprehensible principles of functioning. It has been found that the complex mechanism for implementing the state policy of ensuring the rational use of health products consists in combining the organizational principles of application of priority technologies, forms, methods, instruments and measures (general and special) of state regulation (organizational, legal, administrative, social, economic, information, motivational), aimed at reconciling the interests of all subjects of relations in the healthcare system at different levels of providing medical care and medication supply.The results confirm the medicinal help as a part of social care is free for all the citizens, concerning prescribing drugs and controlling their usage. Therefore we came to a conclusion that the medicinal help is considered to be a social benefit that has a value terms, and it can appear as a service or a concrete material help, such as provision with drugs. The above said led us to a conclusion, that medicinal provision and medicinal help are the parts of the whole medical care system. In the terms of social law, the free medicine includes medicinal help and medicinal provision as essential parts.