Use Of Dentifrice Research Articles

Potential benefits of arginine formulation in oral health care products

AbstractArginine (Arg) is derived from dietary intake, body protein breakdown, and endogenous Arg production, and is also present in saliva. Arg has been introduced as an additive in toothpaste and other fluoride‐containing dental care products and is now being promoted as more efficacious than conventional fluoride‐only toothpaste for the prevention of dental caries. Arg inclusion in dentifrice could potentially inhibit oral biofilm formation and destabilize dental plaque. Arg is expected to inhibit oral biofilm formation and destabilize complex aggregates in dental plaque and its inclusion in mouth rinse could facilitate oral biofilm removal. The destabilization of the oral biofilm by Arg may facilitate the removal of dental plaque during routine oral care. Since removing this solid biological plaque from tooth surfaces by water rinsing or brushing can be difficult, Arg metabolism in oral biofilms leading to an increase in pH decreases the risk for caries development. Moreover, clinical data have shown that Arg‐containing toothpaste increased benefits leading to the prevention of dental caries. However, there are concerns regarding the use of Arg dentifrice in caries progression or regression and some studies contradict the claims of Arg benefits in caries progression or regression.

Effectiveness of Enzyme Dentifrices on Oral Health in Orthodontic Patients: A Randomized Controlled Trial.

Plaque accumulation and white spot lesions are common adverse effects of fixed orthodontic appliance use. This study compared the effects between enzyme-containing and conventional dentifrices on orthodontic patients. This double-blind randomized controlled trial included 42 orthodontic patients (25 women and 17 men: 22.7 ± 4.2 years) from Taipei Medical University Hospital between 2017 and 2018. The patients were randomly divided into three groups and assigned to dentifrice use during the first 3 months of the orthodontic treatment: group 1 used dentifrices containing enzymes including amyloglucosidase and glucose oxidase, group 2 used dentifrices containing 1450 ppm fluoride, and group 3 used natural dentifrices containing no chemical agent. White spot lesion index (WSL), gingival bleeding index (GBI), and visible plaque index (VPI) were recorded and analyzed. WSL, GBI, and VPI values exhibited no significant difference among the three groups. WSL increased significantly in group 3, GBI decreased significantly in all groups, and VPI decreased significantly in groups 1 and 2. No significant difference was observed between the use of enzyme-containing and conventional dentifrices after fixed orthodontic appliance placement.

Maternal report underestimates the amount of dentifrice used by children during toothbrushing: a cross-sectional study

This study investigated whether the report of mothers about the amount of dentifrice applied on a toothbrush could be a reliable method to estimate the inadvertent use of dentifrices. A cross-sectional study was conducted in a randomly selected sample of 334 mothers of children enrolled in public day care centres of a city in the Brazilian northeast. Initially, the mothers chose the figure corresponding to the amount of dentifrice used during their children's daily toothbrushing. Then, they simulated real-life conditions with the toothbrush routinely used to brush the children's teeth. The amount of dentifrice on toothbrush was weighted using an analytical scale. Data were analysed by the Kruskal-Wallis followed by the Dunn test (α = 0.05). The weight of dentifrice on the toothbrush was high (> 0.3g), mainly considering the categories 'covered only' and 'completely covered' that showed no statistical difference (p > 0.05). The proportion of agreement between the mothers' reports and the weight of dentifrice on the toothbrush was 0.23 (CI 0.18-0.28). The mothers' report regarding the amount of dentifrice on the toothbrush by demonstrative figures was not a reliable method to estimate the inadvertent ingestion of fluoride from dentifrices.

Visualization and Quantification of the Oral Hygiene Effects of Brushing, Dentifrice Use, and Brush Wear Using a Tooth Brushing Simulator.

Approaches that reproduce dental hygiene regimens under controlled conditions have applications in preclinical research. We have applied standardized, reproducible brushing regimes to typodonts coated in simulated or biological plaques to assess the effects on tooth cleaning of toothbrush/dentifrice regimens. Replicated typodonts were coated with OccludeTM or GlogermTM indicators to simulate plaque, and brushed reproducibly using a mechanical brushing simulator to compare the cleaning of occlusal surfaces before and after brushing with water or a dentifrice. An in vitro model using salivary inocula to cultivate oral biofilms on typodont surfaces was then developed to evaluate removal of disclosed plaque by new toothbrushes in comparison to toothbrushes with wear equivalent to 3 months of use. Analyses of typodonts brushed under controlled conditions significantly (p < 0.01) distinguished between brushed and unbrushed surfaces and between the use of water vs. dentifrice for the removal of simulated interproximal plaque (p < 0.05). New toothbrushes removed significantly (p < 0.05) more biological plaque from typodont surfaces than brushes that had been worn by repeated brushing. Through controlled and defined brushing of typodonts with simulated and biological plaques, the effectiveness of dental hygiene regimens was compared under reproducible conditions. Data indicate that the cleaning effectiveness of brushing was augmented by the addition of dentifrice and that new brushes were significantly more effective than brushes with substantial wear from previous use. Whilst we have focussed on the occlusal surfaces of molars and worn brushes, the method could be applied to a range of other tooth surfaces and oral hygiene regimens.

Effectiveness of self-applied topical fluorides against enamel white spot lesions from multi-bracketed fixed orthodontic treatment: a systematic review.

The regular use of fluoride dentifrices is quite practical, widespread and linked to global decline of dental caries. However, the role of self-applied topical fluorides in prevention and reversal of Enamel White Spot Lesions (EWSLs) during multi-bracketed fixed orthodontic treatment is not yet explored. To systematically appraise the current literature on the effectiveness of self-applied topical fluorides in the prevention and reversal of EWSLs occurring during multi-bracketed fixed orthodontic treatment. Four electronic databases (Cochrane Library, Embase via Ovid, Medline via Ovid, and Scopus) and gray literature were searched using the broad MeSH terms and keywords. Only randomized/quasi-randomized controlled clinical trials evaluating the effectiveness of self-applied fluorides in the prevention of EWSLs during multi-bracketed fixed orthodontic treatment or reversal of post-orthodontic EWSLs were included. Two reviewers independently screened for studies, extracted data and assessed the risk of bias using the Cochrane risk of bias tool 2.0. Due to substantial variations in the interventions, control groups, and the measurement of outcome among studies, quantitative synthesis could not be performed as planned. Only three studies could be included in the present review; two of them assessing prevention of EWSLs and one addressing reversal of post-orthodontic EWSLs. One of the studies was judged to be of low risk of overall bias, whereas 2 studies were adjudged to be of high risk of overall bias because of deviations from intended interventions. The certainty of evidence about the role of self-applied fluorides in prevention and reversal of EWSLs was found to be of low quality; hence, our confidence in the effect estimate is limited, and future well-conducted trials might alter the effect estimates. The inclusion of only English literature and inability to perform quantitative synthesis due to a limited number of studies. Although the review did not confirm the effectiveness of self-applied fluorides in the reversal of EWSLs, it did partially substantiate the positive role of self-applied fluorides in the prevention of EWSLs occurring during multi-bracketed fixed orthodontic treatment. The review recommends the need for well-designed randomized controlled trials evaluating the effectiveness of self-applied fluorides on the prevention and reversal of EWSLs during multi-bracketed fixed orthodontic treatment. PROSPERO database (Registration number: CRD42018108590) and is freely available at: http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018108590. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

A Clinical Study on the efficacy of Laksha Choorna Pratisarana and Tila Taila Kavala in the control of Danta Sharkara

Introduction: Danta Sharkara (Dental Calculus) is one among the Danta Rogas (Diseases of Tooth) characterized by, hardened accumulation of Mala (dirt) on tooth surface which destroys the teeth and its surrounding structures. It can be compared to Dental calculus, which is a calcified mass that forms on and adheres to the surface of teeth causing periodontal diseases. Modern approach of treatment is Scaling and Root planing. Ultrasonic scalers are used widely by the dentists, which is more efficient method, but it has certain drawbacks. Long term use of mouth washes and dentifrices also have shown adverse effects. Considering these drawbacks in modern dentistry present study was taken up to evaluate the efficacy of local therapeutic procedure mentioned in our classics for calculus removal and its control. Materials and Methods: 40 patients were selected and randomly divided into Group A and B consisting of 20 patients each. Group A was treated by Lakshachoorna Pratisarana (rubbing lac) with Madhu (honey) after Scaling followed by Tilataila Kavala (gargle with gingelly oil) for a period of 3 months. Group B was treated by Ultrasonic Scaling followed by Chlorhexidine mouth wash for a period of 3 months. Result: In the present study, It was found that Group A showed better improvement in calculus index and lesser recurrence rate.

Evaluation of a stabilized stannous fluoride dentifrice on dental plaque and gingivitis in a randomized controlled trial with 6-month follow-up

BackgroundThe objective of this study was to compare a stannous fluoride (SnF2) dentifrice (Colgate TotalSF) stabilized with zinc phosphate with a sodium fluoride control dentifrice for gingivitis and plaque control over a 6-month period. MethodsOne hundred adult participants were enrolled in this study conducted in Chengdu, China. After random assignment and blinding of examiners and patients, enrolled participants received instructions for use of the assigned dentifrice. At 3 visits (baseline and 3 and 6 months), the authors measured various gingival and plaque indexes to determine the clinical efficacy of the stabilized SnF2 dentifrice compared with those of the control fluoride dentifrice (2 groups). ResultsNinety-eight participants completed the study. Both groups (test and control) had statistically significant reductions in gingival inflammation and improvement in plaque control at the 3- and 6-month follow-ups. In addition, the test dentifrice showed statistically significant reductions in all indexes compared with the control dentifrice (P < .001). ConclusionsThis study’s results show statistically significantly improved clinical outcomes for reduction of gingival inflammation and improvement in biofilm control over a 6-month period through the use of a SnF2 dentifrice stabilized with zinc phosphate when compared with results with a fluoride control dentifrice. Practical ImplicationsThis newly formulated dentifrice improves gingival health and plaque control and thereby may aid patients in attaining improved oral health.

Effect of Dentifrice Containing Crab-Shell Chitosan on the Accumulation of Dental Plaque in Fixed Orthodontic Appliances Patients: A Randomized Controlled Trial.

Background:Patients with fixed orthodontic encounter problems in cleaning their teeth and mouths. Dental plaque tends to accumulate on wires, brackets, and surfaces between bonding materials and brackets. Plaque accumulation increases the risks of decalcification, caries, and gingivitis. Chitosan extract is a potential antibacterial agent and inhibitor of dental plaque formation. This study aims to assess the effectiveness of chitosan-containing dentifrice in decreasing plaque accumulation in patients with fixed orthodontic appliances.Materials and Methods:This was a prospective, randomized, double-blind study which involved 32 samples (randomly allocated to the control and chitosan groups, after the power of the study was considered) from patients with orthodontic appliances undergoing the last stage of fixed active orthodontic treatment. Plaque accumulation before and after dentifrice use was measured using a plaque index according to O'leary, before and after using toothpaste within 5 days. The patients were instructed to brushing with chitosan-containing dentifrice and chitosan-free dentifrice as a control. Washout period that needed between brushing with chitosan-containing dentifrice and chitosan-free dentifrice as a control was 7 days. Each mouthwash used routinely for 5 days with the same duration and intensity. The data obtained was then analyzed with one-way analysis of variance followed by post hoc least significant difference. The level of significance was set as 0.05.Results:Plaque accumulation before and after dentifrice use significantly differed (P < 05) between the control and chitosan groups. The average reductions in plaque accumulation were greater in the chitosan group and control group brushing using chitosan-containing dentifrice.Conclusion:Dentifrice-containing chitosan more effectively reduces dental plaque accumulation in patients with fixed orthodontic appliances than dentifrice without chitosan.

Use of Fluoridated Dentifrices among Children: Are We in the Right Direction?

Abstract Introduction Use of topical fluorides in dentifrices has always been an important tool in prevention of dental caries in young children. Due to the easy availability of various low and high fluoride dentifrices, the parents have no clear understanding about their correct age-appropriate use in children. This study was undertaken to evaluate and understand the trend and current practices among the end user. Materials and Methods A total of 173 children aged 4 to 6 years were enrolled in the study from schools located in two different geographical areas of the Chandigarh city; group 1 (n = 90) from a peri-urban slum cluster: (Govt. Primary School, Indira Colony, Mani Majra, n = 51); Govt. Middle School, Mani Majra (n = 39); group 2 (n = 83) from an urban private city school (Ankur, Punjab University, Sector 14) using cluster sampling method. Two examiners using type IV examination examined all the children aged 4 to 6 years present using a preinstructed close-ended questionnaire. Data were analyzed using SPSS Software Version 25 (SPSS Inc., Chicago, IL, United States). Results The data regarding the knowledge of fluoride in pastes showed that 85% of the children were using high fluoride pastes, 10% were using nonfluoride pastes, and 5% were using low fluoride pastes. In group 1, none of the users were aware about the benefits/risk of using fluoride toothpastes and only 22% were aware in group 2. Only 27% of children in group 1 dispensed the correct amount of dentifrice for this age group i.e., a pea head size versus 67% in group 2; a half brush length was dispensed by 61.5% in group 1 and 28% in group 2, and just a smudge by 11.5% in group 1 and 5% in group 2. Forty one percent children in both the groups had a history of having intentionally consumed the toothpaste. The toothpaste was dispensed to the child by parent in 89% of cases in group 2 and only 50% in group 1 and 88% parents claimed to always supervise the child while tooth brushing versus only 53% in group 1. Majority of the respondents’, i.e., 97% in group 1 and 63% in group 2 had never been explained about the correct method of use of fluoride paste in children. Conclusion Knowledge about fluoridated toothpastes is low among the population. The children in peri-urban slums areas are exposed to the high fluoride pastes from very early in life and there is no other toothpaste which is brought home except for those which are commonly used among the members. In the city schools; however, a small percentage of population uses low fluoride pastes in children, possibly due to a greater awareness and access to information, but has no clear idea about their limitations and benefits of age-appropriate use. Till appropriate guidelines are available for the country, a safe practice to follow is tailoring individual need based protocol. The children in peri-urban slums areas need to be educated more on the health practices and importance of use of fluoride dentifrices and the children in the city schools need to be guided more on the age appropriate use of high and low fluoride dentifrices.

Laboratory evaluation of dentin tubule occlusion after use of dentifrices containing stannous fluoride.

The purpose of this study was to examine the effect of desensitizing dentifrices containing stannous fluoride (SnF2) on dentinal tubule occlusion. Two experimental dentifrices with the same ingredients but different SnF2 concentrations (Group II, 0.4% w/w; Group III, 0.454% w/w) were used; distilled water was used in the control group (Group I). Third molars were collected from Japanese and American dental patients. The crowns were removed and sectioned to obtain dentin discs, which were further cut into quarters. Thirty-six specimens each from Japanese and American patients were divided into three sets (n = 12 each) and assigned to each of the three treatment groups. The specimens were brushed for 10 s twice per day for 4 days. After treatment, the discs were observed by scanning electron microscopy, and the extent of dentinal tubule occlusion in the images was expressed on a five-point categorical scale. Group II and III specimens from Japanese and American patients showed greater dentinal tube occlusion than those from Group I, but the differences were not statistically significant. The present results suggest that both SnF2 concentrations mitigate dentin hypersensitivity, regardless of patient ethnicity.

Effects of Dental Hygiene Education on the Use of Dentifrices, Dental Health Behavior and Changes in the Oral Cavity among Dental Hygienist Students

Effects of Dental Hygiene Education on the Use of Dentifrices, Dental Health Behavior and Changes in the Oral Cavity among Dental Hygienist Students

Efficacy of Dental Bleaching with Whitening Dentifrices: A Systematic Review.

A systematic review was performed to evaluate whether whitening toothpastes promote tooth whitening when compared to the use of conventional (nonbleaching) dentifrices. This review was registered at PROSPERO (CRD42017065132) and is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Electronic systematic searches of PubMed/MEDLINE, Scopus, and the Cochrane Library were conducted for published articles. Only randomized clinical trials in adults that compared the use of so-called whitening dentifrices to the use of nonwhitening dentifrices were selected. The outcome was tooth color change. Twenty-two articles from 703 data sources met the eligibility criteria. After title and abstract screening, 16 studies remained, after which a further five studies were excluded. In total, nine studies were qualitatively analyzed. Significant differences in tooth color change were found between the groups using whitening dentifrices and those using nonwhitening dentifrices. Within the limitations of this study, the evidence from this systematic review suggests that bleaching dentifrices have potential in tooth whitening. However, although many whitening dentifrices have been introduced into the dental market for bleaching treatments, it is important to analyze tooth surface and color changes when performing home bleaching.

Comparison of Whitening Dentifrices on the Effectiveness of In-office Tooth Bleaching: A Double-blind Randomized Controlled Clinical Trial.

To investigate the effect of whitening dentifrices on the effectiveness of in-office tooth bleaching. A double-blind randomized controlled clinical trial was performed. The participants were randomly allocated into three groups according to the different dentifrices used during this clinical trial: regular dentifrice (group C), conventional whitening dentifrice (group CW), and whitening dentifrice containing blue covarine (group CU). All participants received in-office tooth bleaching for the maxillary anterior teeth (two sessions conducted at a one-week interval). Tooth color was measured with a spectrophotometer at baseline (T1), after the first bleaching session (T2), after the second bleaching session (T3); one week after the completion of in-office bleaching (T4); and three weeks after the completion of in-office bleaching (T5). The data were statistically analyzed through repeated analysis of variance and the Tukey test (α=0.05). Sixty participants completed the study (n=20 per group). At T3, group CU exhibited the lowest ΔE values ( p=0.008). The ΔE values increased from T4 to T5 in the CW and CU groups, whereas a decrease in ΔE values was observed for group C. The use of a whitening dentifrice containing blue covarine during in-office bleaching reduced color changes. After tooth bleaching, brighter tooth colors were observed in the participants who brushed with whitening dentifrices compared to those who brushed with a regular dentifrice.

Randomized exploratory study to measure ion release from calcium sodium phosphosilicate-containing dentifrice.

This exploratory study investigated salivary concentrations of silicon, calcium, sodium, and phosphorous over a 60-min time period following the use of a calcium sodium phosphosilicate (CSPS)-containing dentifrice. Participants brushed with a dentifrice containing 5% (w/w) or 0% (w/w) CSPS or swilled with a slurry containing 5% (w/w) CSPS/glycerol. Saliva samples were collected before, and 2, 5, 15, and 60min after, product use and were analysed using inductively coupled plasma optical emission spectroscopy. Intra-oral pH measurements were also taken. Primary analysis was of centrifuged saliva supernatant containing only dissolved material. At most time points, the CSPS-containing dentifrice and slurry generated significantly more salivary silicon than the dentifrice containing 0% CSPS. At 2-15min after brushing there was significantly more salivary calcium after use of the CSPS-containing dentifrice and slurry, compared with the 0% CSPS dentifrice; a significant reduction, from baseline, in salivary calcium after use of dentifrice containing 0% CSPS; and an increase in salivary sodium after use of dentifrices containing either 5% or 0% CSPS, but no differences between them. Salivary phosphorous concentration decreased significantly with all treatments 2-5min after use. There were no significant between-treatment differences in intra-oral pH. Products were generally well tolerated. This study establishes that it is possible to measure changes in salivary ionic composition derived through oral retention of CSPS, delivered via a dentifrice.

Knowledge of primary care professionals about fluoride topics.

Scientific evidence on the benefits of fluoride was responsible for an important change in dental practice. Individual and collective actions have been planned to impact the epidemiology of oral health. However, questions around this topic persist, making discussions and researches still necessary. In this regard, the aim of this study was to verify the fluoride-related knowledge of pediatricians (PP) and dentists (DS) working in primary care, comparing related aspects such as its multiple sources of intake and dental fluorosis. A group of PP and DS answered as self-administered questionnaire related to fluoride knowledge. PP group presented a lower level of adherence (34%) in comparison to the DS group (70%). Fluoride-related topics were learnt at undergraduate courses by 95,95% of dentists and 38.46% of pediatricians. Ninety-two per cent of DS and 78.57% of PP claimed to know the clinical aspects of dental fluorosis. Pediatricians tend to indicate the use of fluoridated dentifrices at any age but advise less about the right amount to be placed on the toothbrush in comparison to DS. Dentists and pediatricians presented limited fluoride-related knowledge. Continued education/training is encouraged and necessary at this level in order to deliver the benefits of fluoride use to populations.

A randomized triple-blind crossover trial of a hydrocolloid-containing dentifrice as a controlled-release system for fluoride.

To evaluate retention of intraoral fluoride in biofilm and saliva, an experimental dentifrice containing hydrocolloid (tara gum) was used as a controlled-release system for fluoride (F). In a triple-blind randomized crossover trial with washout, 18 individuals used the following different dentifrices for a week: 100-TGF (sodium fluoride NaF associated with tara gum, 1100mg/L), 50-TGF (50% NaF associated with tara gum + 50% free NaF, 1100mg/L), PC (free NaF, 1100mg/L), TG (with tara gum and without F), and placebo (without F or tara gum). On the seventh day of dentifrice use, biofilm was collected at 1 and 12h, and saliva was collected up to 60min and 12h after the last toothbrushing. F concentrations were determined by physico-chemical analysis of fluoride using the hexamethyldisiloxane-facilitated diffusion technique. Data were subjected to two-way analysis of variance (repeated measures) and Spearman's correlation coefficient (p < 0.05) testing. No significant difference was observed with the same dentifrice regarding F retention in biofilm at 1 and 12h after toothbrushing for the 100-TGF, placebo, and TG groups (p > 0.05). The highest area under the curve values in saliva were found for the 50-TGF, 100-TGF, and PC groups. The dentifrice containing hydrocolloid as a controlled-release system for F promoted F retention in the oral cavity, even at 12h after brushing. Hydrocolloid added to dentifrices as a controlled-release system for F might contribute to a higher anti-caries effect. NCT02809014.

Knowledge of Brazilian Dental Students about the Use of Conventional Fluoride Dentifrices for Preschool Children from Zero to Six Years Old

Objective: To verify the knowledge of dental students about the correct use of fluoride dentifrices above 1000 pmm fluorine for children aged 0-6 years old. Material and Methods: This is a cross-sectional study in which self-administered questionnaires were administered to 355 dental students from sixth to ninth or tenth graduation period. The questionnaires included questions regarding knowledge of the need to use, concentration, amount, frequency and potential adverse effects of the use of conventional fluoride dentifrices above 1000 ppm of fluorine by children up to six years of age, as well as the mechanism of action and the method of using fluorides that has the most scientific evidence. A descriptive analysis of data was performed. Results: 83.1% of students reported receiving content on the use of fluoride dentifrices in early childhood. Most students consider the use of fluoride dentifrice as important for the age group from zero to three years (73.8%) and from three to six years (96.4%). Only 17.7% would indicate fluoride toothpaste above 1000 ppm fluoride for children from zero to three years and 40.6% for three to six years. 76.9% believe that the amount of ideal refers to a grain of rice (0-3 years) and 61.7% of pea grain (3-6 years). 43.4% of students believe that fluoride dentifrices as an adverse effect the potential to cause fluorosis independent of concentration. Conclusion: The students evaluated were misleading about the fluoride concentration of the dentifrices indicated for children up to six years of age; on the toxicity of fluorine; action mechanism of fluorides and the scientific method of greater scientific evidence on caries disease. Failures in training and need to update fluoride contents to be taught to future dentistry professionals are evident.

Erosive tooth wear in an asthmatic child: a case report.

Introduction: Erosive tooth wear (ETW) is defined as a mechanical chemical process that results in a cumulative loss of hard tissue without the involvement of bacteria. This process may occur in permanent and deciduous teeth and may also reach the dentin tissue. Patients who report chronic diseases, such as respiratory allergy and bronchial asthma, or recurrent acute diseases, such as tonsillitis, allergic rhinitis, sinusitis, and otitis, commonly use drugs for prolonged periods; thus, more attention should be given to the dental aspects since the drugs may cause undesirable effects. Objective: This paper aims to report and discuss a clinical case of a nine-year-old, male, Caucasian, asthmatic patient who continually uses anti-asthmatic medications and has developed ETW. Case report: According to the patient’s needs, oral hygiene instructions (use of fluoride stannous dentifrice, dental floss, and topical fluoride applications), daily use of mouthwash solution containing 0.05% sodium fluoride, and dietary guidance were recommended. Conclusion: An early and accurate diagnosis of ETW lesions and recognition of specific etiological factors allow the professional to elaborate an individualized prevention and control program for ETW progression.

Effect of high concentrated fluoride-based dentifrice on the hardness, roughness, and color of the bleached enamel.

Context:Remineralizing agents have been recommended to restore the integrity of bleached enamel.Aims:The aim of this study was to evaluate the effect of fluoride at high concentration (5000 ppm) applied to bleached enamel.Materials and Methods:A total of 30 specimens obtained from newly extracted third molars were divided into two groups (n = 15) as follows: control group and fluoride group. Specimens of both groups received bleaching treatment with 35% hydrogen peroxide, were then submitted to the Vickers hardness number/colorimetric test (VHN/CT) (n = 5) and Ra (n = 10) tests, and stored in artificial saliva. After bleaching, fluoride group received the application of a fluoride-based dentifrice, during 5 min. VHN, RS, and CT analysis of both groups were performed before and after treatments. For VHN, five indentations per specimen were performed, using a microdurometer. Ra analysis was performed with a rugosimeter. The color was analyzed through the CIE L* a* b* system, respectively, using a colorimeter.Statistical Analysis:For intergroup statistical analysis, ANOVA with Tukey's posttest was used. All tests were calculated at a significance level of 5%.Results:There was statistically significant difference (P < 0.01) between the analyzed groups, on VHN, Ra, and CT evaluations.Conclusions:The use of fluoride-based dentifrice at 5000 ppm was effective in minimizing the deleterious effects on bleached enamel.

A randomised clinical evaluation of a fluoride mouthrinse and dentifrice in an in situ caries model

ObjectivesFluoride mouthrinses provide advantages for fluoride delivery by maintaining elevated intra-oral fluoride concentrations following fluoride dentifrice use. This in situ caries study investigated potential anti-caries efficacy of a 220 ppm fluoride mouthrinse. MethodsThis was an analyst-blinded, four-treatment, randomised, crossover study using partially demineralised, gauze-wrapped, human enamel samples mounted in a mandibular partial denture. Participants brushed twice daily for 14 days with either a 1150 ppm fluoride or a fluoride-free placebo dentifrice and either rinsed once daily with the 220 ppm fluoride mouthrinse or not. Following each treatment period, percent surface microhardness recovery (%SMHR) and enamel fluoride uptake (EFU) were assessed. ResultsFifty three participants completed the study. Compared with the placebo dentifrice/no rinse treatment, the fluoride-containing regimens demonstrated greater enamel remineralisation (%SMHR) and fluoridation (EFU): fluoride dentifrice/fluoride rinse (%SMHR difference: 21.55 [95% CI: 15.78,27.32]; EFU difference 8.35 [7.21,9.29]); fluoride dentifrice/no rinse: 19.48 [13.81,25.15]; 6.47 [5.35,7.60]; placebo dentifrice/fluoride rinse: 16.76 [11.06,22.45]; 5.87 [4.72,7.00] (all P < .0001). There were no significant differences in%SMHR between fluoride regimens. The fluoride dentifrice/fluoride rinse regimen was associated with higher EFU than the fluoride dentifrice/no rinse (1.88 [0.75,3.01], P = .0013) and placebo dentifrice/fluoride rinse regimens (2.48 [1.34,3.62], P < .0001). Treatments were generally well-tolerated. ConclusionsThe in situ caries model demonstrated that the fluoride mouthrinse is effective in promoting enamel caries lesion remineralisation and fluoridation whether used following a fluoride or non-fluoride dentifrice. Additive (potential) anti-caries benefits of a fluoride rinse after a fluoride dentifrice were confined to enhancements in lesion fluoridation (EFU). Clinical significanceIn conjunction with a fluoride dentifrice, fluoride mouthrinses enhance enamel fluoridation, which may be useful in caries prevention.