Aim: The aim of this study was to evaluate and compare the surface roughness of Cention N and Filtek Z350 XT resin composite. Null Hypothesis: There is no difference observed in surface roughness between the Cention N and Filtek Z350 XT resin composite. Introduction: The use of resin composites in restorative dentistry has markedly increased in recent years due to increased demand for esthetics. The advent of novel fluoride-releasing resin composite Cention N has brought enormous benefits. Finishing and polishing of composite resin restorations are essential steps in restorative dentistry. However, there are no studies available in literatures regarding the effective use of Soflex finishing and polishing with Cention N. Hence, the purpose of the study was to evaluate the surface roughness of novel resin composite Cention N and compare with Filtek Z350 XT resin composite. Materials and Methods: Sixty-four specimens were prepared in Teflon plastic mold of 8-mm diameter and 2-mm thickness, and were divided into group 1 (Filtek Z350 XT [n = 32]) and group 2 (Cention N [n = 32]). They were further subdivided into group 1A (Matrix finish [n = 16]) and 1B (Soflex [n = 16]), and group 2A (Matrix finish [n = 16]) and 2B (Soflex [n = 16]). Surface roughness was measured using surface profilometer. Results: When comparing the mean values and standard deviations of surface roughness of four groups using one-way ANOVA, it was found that there was a significant difference (P < 0.001) in mean surface roughness between the four groups. Conclusion: All the groups presented the values that are below or approximating baseline value for bacterial or plaque retention.