Car Use Research Articles

Analyzing the Impact of Perceived Exertion on Walking for Short-Distance Trips: A Comparative Case Study of Malta and the Netherlands

Understanding people’s travel behavior is key to creating spaces that discourage car use, especially for short, walkable distances. The scope of this study is to understand better people’s propensity to use a car rather than walk for short-distance trips by focusing on the concept of perceived exertion (PE). A comparison is performed of two case study locations: Malta, a Euro-Mediterranean island with a high car dependency, and the Netherlands, a European country with a high active mode share of walking and cycling. Surveys were distributed to two university populations in each of the case study locations to analyze the parallels and variations in travel behavior and perceptions. Applying a mediation model analysis, the results show a partial mediation (Malta) and a full mediation (Netherlands) of PE in the relationship between car use frequency (CF) and distance threshold (DT), that is, the distance people are willing to walk rather than use a car. The mean DT for walking varied significantly between the two samples, resulting in 15.18 min (1.2 km or 0.7 mi) in the Netherlands and 17.99 min (1.4 km or 0.9 mi) in Malta, despite the comparatively larger active mode share in the Netherlands. Complementing this, the ordinal logistic models for the two countries indicate that those that perceive walking for short trips to be more effortful and those with a high CF are less inclined to walk long distances. Findings are compared with previous research, and policy-relevant suggestions based on these findings are provided.

Road space reallocation in Scotland: A health impact assessment

IntroductionRoad space reallocation involves re-distributing space away from motor vehicles, including car parking and carriageway space, towards other uses. This can promote a shift to more sustainable travel modes and is likely to affect health through multiple pathways. MethodsWe conducted a health impact assessment to identify and assess the potential impacts of road space reallocation on health and health inequalities in Scotland. This involved a facilitated scoping workshop to identify potential impacts, collation of routine data, interviews with 13 key informants and a rapid review of research literature. ResultsWe found that road space reallocation could have positive impacts on health by reducing overall levels of private motorised traffic, encouraging walking, wheeling and cycling, realising benefits from alternative uses of space and supporting local businesses. There is potential for positive impact on public transport if space is reallocated to prioritise buses, but bus users can also be disadvantaged if bus routes are diverted or stops impeded. Reallocation can improve transport and health equity if it increases support for modes other than car use, but disabled people may be disadvantaged if the reallocated space, and alternative modes, are not accessible for them. ConclusionsRoad space reallocation can improve health and help reduce health inequalities. However, consideration is needed to ensure sufficient alternatives to car use are supported and the reallocated space is accessible for people with different needs. Reallocation schemes should be considered as part of a wider inclusive approach to road transport supporting active travel and public or community transport. Road space reallocation should contribute to wider place-making initiatives aiming to improve quality of local environments and meet community needs.

A novel method for industrial production of clean hydrogen (H2) from mixed plastic waste

This study describes a novel Hybrid Microwave Plasma Enhanced Gasification (HMPEG) method for converting plastic waste into hydrogen (H2). Thermal processing of plastic waste is a low-cost method of producing H2. Current methods, however, such as pyrolysis and gasification, are limited by inefficient heating and contaminants in syngas, resulting in a low H2 yield. Our approach consists of a novel rotary pyrolysis reactor that employs an external microwave heater and an electrodeless microwave torch reformer, thereby addressing issues with current methods. In this study, pyrolysis of mixed plastic produces pyro-gas which is reformed at a temperature above 1500 °C by the steam plasma torch powered by microwave. The result is a 150 g/kg H2 yield with a 67 vol.% higher production rate, an H2/CO ratio of 7, and a conversion efficiency of 97.4%. Tar and dioxin concentrations in the syngas were found to be 0.078 g/Nm3 and 0.024 ng-TEQ/Nm3, respectively, much less than the legal limit. A novel microwave pyrolyzer cuts electrical power consumption by half, and the pure H2 produced is suitable for direct use in hydrogen cars, power generation, and other applications. Once implemented, the energy-efficient HMPEG could aid in expanding H2 commercial plants that use plastic waste as a raw input fuel.

CI-452764-2 HIGH-POWER CHARGERS FOR ELECTRIC VEHICLES: ARE THEY SAFE FOR PATIENTS WITH PACEMAKERS AND DEFIBRILLATORS?

Electromagnetic interference (EMI) poses a risk to patients with cardiac implantable devices (CIEDs) and can result in device malfunction including pacing inhibition or inappropriate shock therapy. Such EMI sources are ubiquitous in the modern world. Battery electric vehicles (BEVs) represent such a potential EMI source. We have previously investigated the EMI risk of driving eCars and found that the largest electromagnetic field is located along the charging cable. New high power chargers deliver higher currents (facilitating rapid recharging), potentially associated with greater electromagnetic fields and higher risk for clinically relevant EMI. This present study aims to evaluate this EMI-risk for CIED patients while using high-power chargers for electric vehicle A consecutive group of 130 patients with a range of CIEDs were recruited to participate. After a complete device interrogation each had their device programmed to optimise EMI detection with ensured ventricular pacing and ICD therapies were disabled. Under continuous 6-lead ECG monitoring each patient then plugged in and charged four different BEVs (Porsche Taycan Turbo, VW ID3 pro, Tesla Model 3 and Audi e-tron 55 Quattro) in addition to a ‘dummy’ eCar (which permitted the maximal charging power flow of 350kW) with the charging cable placed directly over the device (Figure 1). During charging both the magnetic field and electric field was measured. A further complete device interrogation was then performed to evaluate for spontaneous reprogramming and tachycardia detection. In total 561 separate charging events were performed by 130 patients with the four eCars and one dummy car. There were no incidences of EMI, specifically there was no pacing inhibition due to oversensing, no spontaneous reprogramming and no tachycardia over-detection. This results in a patient-based risk of 0% (95% CI; 0% - 2.8%) and a charging event-based risk of 0% (95% CI; 0% - 0.6%). The use of electric cars with high-power chargers by patients with cardiac devices appears to be safe with no evidence of clinically relevant EMI. Reasonable caution, by minimising the time spent in close proximity with the charging cables, is still advised as the occurrence of very rare events cannot be excluded from our results.

"Kind of empowered": Perceptions of socio-emotional development in children driving ride-on cars.

Early powered mobility (PM) experiences can be essential facilitators of self-initiated mobility, socialization, and exploration for young children with disabilities. Cerebral palsy (CP) and developmental delay are two of the most common diagnoses associated with motor disability in young children with 1 in 345 children diagnosed with CP and 1 in 6 with developmental delay in the US. The purpose of this study was to explore the longitudinal experiences and caregiver perceptions of socio-emotional development in particular, in young children with disabilities during modified ride-on car (ROC) use. A qualitative, grounded theory approach was used. Semi-structured interviews were conducted with 15 families (children ages 1-4 with CP or developmental delay) at baseline, 6 months (as able due to COVID), and 1 year following ROC introduction. Data were coded independently by three researchers using constant comparison until data saturation occurred and themes emerged. Four themes emerged from the data: "Leveling the Playing Field," "Breaking Down Barriers," "Fun and Work: ROC as Toy and Therapy Device," and "Mobility is a Pathway to Autonomy." Conclusions/Implication: Children and caregivers viewed ROCs as both fun and therapeutic, consistently identifying perceived benefits for children's socio-emotional development. This qualitative study provides a better understanding of the complexities and impact of ROCs on children and their families in the socio-emotional domain and may help facilitate clinical decision-making when introducing PM to young children with disabilities as part of a multimodal approach to early intervention. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Can Bike-Sharing Reduce Car Use in Alexandroupolis? An Exploration through the Comparison of Discrete Choice and Machine Learning Models

The implementation of bike-sharing systems (BSSs) is expected to lead to modifications in the travel habits of transport users, one of which is the choice of travel mode. Therefore, this research focuses on the identification of factors influencing the shift of private car users to BSSs based on stated preference survey data from the city of Alexandroupolis, Greece. A binary logit model is employed for this purpose. The estimation results indicate the impacts of gender, income, travel time, travel cost and safety-related aspects on the mode shift, through which behavioural insights are derived. For example, car users are found to be twice as sensitive to the cost of BSSs than to that of car. Similarly, they are highly sensitive to BSS travel time. Based on the behavioural findings, policy measures are suggested under the following categories: (i) finance, (ii) regulation, (iii) infrastructure, (iv) campaigns and (v) customer targeting. In addition, a secondary objective of this research is to obtain insights from the comparison of the specified logit model with a machine learning approach, as the latter is slowly gaining prominence in the field of transport. For the comparison, a random forest classifier is also developed. This comparison shows a coherence between the two approaches, although a discrepancy in the feature importance for gender and travel time is observed. A deeper exploration of this discrepancy highlights the hurdles that often occur when using mathematically more powerful models, such as the random forest classifier.

Frequency of child restraint system use and parental knowledge of such systems in western China.

This study investigated the frequency of child restraint system (CRS) use in cars and assessed parental knowledge and attitudes toward such restraint systems in western China. Cross-sectional survey. This cross-sectional survey was conducted between December 2021 and January 2022. Hospitals and kindergartens were convenience sampling selected, and parents with cars were asked whether they owned and used CRS. Parents' knowledge and attitudes toward such systems were also determined. Factors associated with CRS were explored using binary logistic regression. A total of 4764 questionnaires were distributed to parents with children 0-6 years old. Among the 4455 responses received, 50.8% of the respondents owned CRS, and most of which were front-facing child seats (42.0%). Less than half (44.4%) reported using a CRS sometimes, but only 19.6% used it all the time. The possession and use of a CRS varied significantly with the parental education level, age of the child, place of residence, number of children, family income, travel frequency, and travel distance. Logistic regression analysis showed that the frequency of car travel with a child and monthly family income significantly affected CRS use. Most parents (85.2%) perceived that adult seat belt in cars are effective at protecting their children in the event of a crash. The most frequent reason for not using a CRS was the tendency for children to travel in the car less often. Although approximately half of the respondents owned a CRS, most of them used it rarely, if at all. Educating parents about safe ways for children to ride in a car and use of safety belts may promote CRS use.

Pedestrian mobility in Mobility as a Service (MaaS): sustainable value potential and policy implications in the Paris region case

Pedestrian mobility remains neglected in MaaS solutions, yet it has the potential to become a tool for promoting public policies and more sustainable lifestyles away from excessive private car use. This research identifies the potential for sustainable value creation and the transversal implications for policymakers and other MaaS stakeholders of overlooking walking in innovations like MaaS. To do so, we explore how walking is currently integrated into four MaaS solutions in the Paris region. Our main findings show heterogeneity in the hierarchy given to walking in the user interfaces and the determinant roles of governance and policy in supporting the prioritization of pedestrian mobility in MaaS.

Interaction between attribute importance and user satisfaction on the promotion of public transport

Latin American countries have common characteristics: increase in automobile use, and decrease in the interest of users for public transport by bus caused by unsustainable urban mobility. Of these, users’ interest in public transport by bus has the most significant potential for sustainable transport changes. Therefore, this paper aimed to understand how the interaction between the importance and satisfaction of users to transport attributes can help promote the increase in the passengers’ transport demand in medium-sized cities of developing countries. The interaction between the users’ stated importance and the users’ satisfaction for automobile and public transport by bus was analyzed regarding attributes of safety, comfort, transport costs, and travel time. The study was performed in the city of Barreiras, state of Bahia, Brazil. Likert scale data analysis used three approaches that set unique importance and satisfaction ratings employed on the graphic tool Importance-Performance Analysis. It was concluded that interaction between the data of importance and satisfaction is effective, reliable, and allows the comparative analysis between the transport attributes, enabling the prioritization of strategies that help the promotion of passenger transport.

Is It Possible to Compete With Car Use? How Buses Can Facilitate Sustainable Transport

The need to prioritise the development of bus transport has attracted widespread attention in the literature. This study aims to investigate how buses can be used to facilitate a sustainable transport system, using Heze, in China, as a case study. Our results show that older people, unemployed residents, and those whose points of departure or arrival are within the city centre are more likely to travel by bus. In addition, compared to other travel modes, travel by bus tends to become more popular as travel time and distance increase. We predict the probabilities of people using buses for journeys of different travel times and over varying distances and rank them in order. The results suggest that bus travel could potentially replace car travel when the travel time is between 15 and 30 minutes or the travel distance is more than 9 km. In terms of policy implications, governments and planners should pay more attention to creating additional bus lanes, extending the bus network and its infrastructure, optimising bus-related facilities and services, particularly for older adults, and increasing the punctuality and reliability of bus travel.

The impact of urban road pricing on the use of bike sharing

We empirically analyse the effect of road pricing on the use of bike sharing. We exploit two sudden policy changes in Milan's congestion pricing scheme resulting in a shift from priced to unpriced road use: a temporary suspension of the scheme in 2012, and a durable reduction in its application schedule. We find that the sudden removal of road pricing decreases bike-sharing use by about 5%. The policy impact mainly occurs through the increase of road traffic congestion, which makes cycling less safe and pleasant. The reduction in the schedule leads to an 8% decline in bike-sharing use in the affected time window. Our findings indicate that policies inducing drivers to internalise the external costs of car use also promote the uptake of non-polluting transport modes. This widens the spectrum of benefits that need to be considered in the design and implementation of road pricing policies.

“Evaluation of an electromagnetically actuated drum brake concept”

In publications and conferences on the subject of wheel brakes, different concepts of electromechanically actuated wheel brakes can be found, as well as investigations into their suitability for the use in passenger cars. The vast majority of these brakes are disc or drum brakes, which are actuated by an electric motor. In the present publication, a brake concept is considered, that combines an electromagnetically actuated full-pad disc brake with a 10″ duo-duplex drum brake. The brake concept is researched in a project regarding brakes for autonomous shuttles and thus dimensioned using vehicle data of an example shuttle. The electromagnet was designed using finite element methods and the overall brake prototypically realized. The validation of the system design is carried out in component and system tests. The results show the suitability of the concept for the selected vehicle in terms of dynamics, installation space and energy requirements. However, there is a strong dependence of the braking torque output on the frictional sliding speed. Using hypothesis-based testing, electromagnetic effects like eddy currents are ruled out as a possible cause and the friction coefficient within the full-pad disc brake is identified as the main cause for the loss in torque. Consequently, the associated development conflict is identified and lies in the double function of the flux-carrying material in the electromagnet, which also acts as a friction partner for the braking disc.

COVID-19 Safety Protocols: Do Commuters Prefer Public Transport after Relaxation of Safety Protocol Enforcement?

There is a current discourse on how COVID-19 will impact future use of public services by people. At the time of writing this paper, most countries around the globe have relaxed safety protocol enforcement. This may change individual use of public transport, and policy implementations. The study mainly used Multinomial Logistic Regression (MLR) to examine the use of public transport ridership after the relaxation of COVID-19 safety protocol enforcement. A survey was used to collect data from 1692 respondents across Ghana partly online and partly face-to-face interviews from April 20^th, 2022 to June 5^th, 2022. The preliminary findings show that the use of private cars declined during the enforcement of safety protocols. However, after relaxation of safety protocol enforcement, the use of private transport increased more than public transport. The Relative Importance Index revealed that 'facemask wearing covering both nose and mouth', 'reduction in the number of occupants per vehicle', 'the use of alcohol-based hand sanitizer', and 'vehicles cleaned after every trip' were the most important safety protocols perceived to prevent infection of virus. However, the MLR model shows that largely, relaxation of mandatory facemask wearing, social distancing, hand hygiene, and disinfection of transport could decrease public transport ridership. These findings suggest that the COVID-19 infection anxiety has not faded and could decrease public transport ridership. To relieve the anxiety regarding virus infection through the use of public transportation, the government needs to take appropriate measures to lower the perceived risk of infection.

Scale to measure motives for car use and personal norms for reducing car use in the metropolitan area of the Valley of Mexico (Escalas de motivos para uso del auto y de norma personal de reducción del uso de auto en la Zona Metropolitana del Valle de México)

ABSTRACT The motives for car use and the personal norms for reducing car use have been studied to understand the motivational processes underlying car use. Motives have been classified as instrumental, symbolic and affective, while personal norms have been classified as introjected and integrated. The aim of this study is to validate scales measuring motives for car use and personal norms for car use reduction in Mexico City. Both scales were applied, together with a measure of car use, to a sample of 257 motorists. The results indicate a good fit for the three-factor model for the motives for car use scale and a good fit for the two-factor model for personal norms for car use reduction. A linear regression model was run, which showed that both constructs explain 21.3% of variance in car use, and the significant predictors are instrumental motives and integrated norms. Both scales show initial evidence of reliability, validity and parsimony.

The effect of sustainable mobility transition policies on cumulative urban transport emissions and energy demand

The growing urban transport sector presents towns and cities with an escalating challenge in the reduction of their greenhouse gas emissions. Here we assess the effectiveness of several widely considered policy options (electrification, light-weighting, retrofitting, scrapping, regulated manufacturing standards and modal shift) in achieving the transition to sustainable urban mobility in terms of their emissions and energy impact until 2050. Our analysis investigates the severity of actions needed to comply with Paris compliant regional sub-sectoral carbon budgets. We introduce the Urban Transport Policy Model (UTPM) for passenger car fleets and use London as an urban case study to show that current policies are insufficient to meet climate targets. We conclude that, as well as implementation of emission-reducing changes in vehicle design, a rapid and large-scale reduction in car use is necessary to meet stringent carbon budgets and avoid high energy demand. Yet, without increased consensus in sub-national and sectoral carbon budgets, the scale of reduction necessary stays uncertain. Nevertheless, it is certain we need to act urgently and intensively across all policy mechanisms available as well as developing new policy options.

High-power chargers for electric vehicles: are they safe for patients with pacemakers and defibrillators?

Battery electric vehicle (BEV) sales and use are rapidly expanding. Battery electric vehicles, along with their charging stations, are a potential source of electromagnetic interference (EMI) for patients with cardiac implantable electronic devices (CIEDs). The new 'high-power' charging stations have the potential to create strong electromagnetic fields and induce EMI in CIEDs, and their safety has not been evaluated. A total of 130 CIED patients performed 561 charges of four BEVs and a test vehicle (350 kW charge capacity) using high-power charging stations under continuous 6-lead electrocardiogram monitoring. The charging cable was placed directly over the CIED, and devices were programmed to maximize the chance of EMI detection. Cardiac implantable electronic devices were re-interrogated after patients charged all BEVs and the test vehicle for evidence of EMI. There were no incidences of EMI, specifically no over-sensing, pacing inhibition, inappropriate tachycardia detection, mode switching, or spontaneous reprogramming. The risk of EMI on a patient-based analysis is 0/130 [95% confidence interval (CI) 0%-2%], and the risk of EMI on a charge-based analysis is 0/561 (95% CI 0%-0.6%). The effective magnetic field along the charging cable was 38.65 µT and at the charging station was 77.9 µT. The use of electric cars with high-power chargers by patients with cardiac devices appears to be safe with no evidence of clinically relevant EMI. Reasonable caution, by minimizing the time spent in close proximity with the charging cables, is still advised as the occurrence of very rare events cannot be excluded from our results.

Smart Mobility in Urban Areas: A Bibliometric Review and Research Agenda

Transportation systems globally face challenges related to congestion, decreased quality of life, limited accessibility, increased harmful emissions and costs, growing use of private cars and in some cases lack of intra and intermodal integration. Smart Mobility is believed to be a solution to some of these challenges by providing comprehensive and intelligent mobility services, decreasing transportation costs, promoting safety, and combating pollution and traffic congestion. Despite this potential, there is still uncertainty surrounding what smart mobility is and whether it is moving toward improving the quality of life and making cities more sustainable. To address this gap, this paper conducts a bibliometric review of 3223 Web of Science Core Collection-indexed documents to provide a comprehensive understanding of smart mobility research. The findings reveal a lack of multi-disciplinary approaches in previous studies with a strong emphasis on technological aspects and limited social or economic considerations in current research. The review identifies four distinct periods of smart mobility research, with recent interest sparked by advancements in big data, deep learning, artificial intelligence, and real-time technologies in transport systems. However, there is a dearth of research on smart mobility in developing countries, where urban populations are rapidly increasing. Thus, the review proposes a research agenda to address the current gaps in knowledge. Furthermore, the review provides an updated and integrated definition of smart mobility as the use of advanced technologies, such as the Internet of Things (IoT), big data analytics, and artificial intelligence, to improve transportation efficiency, mobility for all, and sustainability while safeguarding the quality of life. The primary challenge for smart mobility is the co-evolution with existing transport systems, making further research on integration with these systems and real-time technologies essential for advancing smart mobility research. The paper’s main contribution is an integrated conceptualisation of smart mobility research and novel research topics that build on this unified base.

The Effects of Seoul’s Greenbelt on Travel Mode Share in Its Inside and Outside: A Spatial Panel Econometric Analysis

The primary purpose of urban growth management policies is to control urban sprawl and induce the diversification of travel mode share. Hence, how the greenbelt, as an urban containment policy, affects travel mode share is one of the important issues in understanding the efficacy of urban growth management. To analyze it for the Seoul Metropolitan Area (SMA), which has designated its greenbelt for more than forty-five years, this study implemented the spatial Durbin panel regression for the years from 2002 through 2016. Results showed that the greenbelt increased the use of public transportation and decreased car use, but it tended not to increase the use of nonmotorized modes of transportation such as bicycling and walking. There also turned out to be U-shaped (convex) relationships both between population density and car use and between the former and bicycling. Meanwhile, an inverted U-shaped relationship was observed between population density and public transportation mode, which was statistically significant. Based on these results, it can be said that a public transportation system outside of the greenbelt is needed for increasing its accessibility. To promote the use of public and nonmotorized transportation, it will also be important to determine the appropriate urban density.

Car driving as inverted quarantine and the sensory response to collective threats: challenges for public transport

ABSTRACT Attempts at changing individual car use behavior towards increased use of public transport have so far largely failed. This paper will argue that the continued rise in individual car use needs to be understood as part of an overall trend towards protecting oneself instead of protecting the environment, i.e. an individualized sensory response to an omnipresent collective threat. The car industry serves this trend perfectly with features that turn cars into “cozy” cocoons that protect passengers from the dangers of the outside world. Although the Covid-19 pandemic has fostered this trend, it has been inherent in the resistant nature of cars for decades. Thus, today cars are increasingly used for their sensory aspects related to safety and protection from an infectious, dirty, and violent outside world. This trend is supported by highly individualized cushioning and comfort factors that make cars “special places.” Any strategies for promoting alternative forms of transport thus need to consider these sensory developments when creating incentives for people to travel by train, bus, etc. instead of driving cars. The paper ends with a few speculations on how public transport could be made more attractive given the current role of sensory perception in car driving.

Abstract CT125: A Phase 1 study to evaluate the safety and tolerability of a combination autologous CD19 CAR T cell therapy (SYNCAR-001) and orthogonal IL-2 (STK-009) in subjects with relapsed or refractory CD19 expressing hematologic malignancies (NCT05665062)

Abstract Background: Chimeric antigen receptor T cell therapy (CAR T) has demonstrated remarkable clinical efficacy in hematological malignancies. However, compromised T cell effector function, proliferation, and persistence can limit CAR T from reaching their full curative potential. Interleukin-2 (IL-2) is a potent stimulator of T cells, however therapeutic use of IL-2 is limited by systemic toxicity due its pleiotropy. Therefore, to provide a selective IL-2 signal to engineered T cells, we have developed a human orthogonal ligand/receptor system consisting of a half-life extended pegylated IL-2 mutein (STK-009) and a mutated IL-2 Receptor Beta (hoRb) that responds to STK-009 but not wild type IL-2. SYNCAR-001 is an autologous CAR T co-expressing a CD19 CAR and hoRb on the T cell surface. In mouse models of refractory lymphoma, STK-009 treatment led to expansion and activation of SYNCAR-001 cells with a maintenance of stem cell memory and effector T cell phenotypes. When added to SYNCAR-001, STK-009 increased complete response rate and durable responses in a dose dependent manner. In non-human primate studies, STK-009 alone demonstrated no significant biological activity in IL-2 sensitive populations (T cells or NK cells) and was tolerable without toxicity. Methods: This is a first-in-human, open-label, dose escalation study of combination SYNCAR-001 + STK-009 in adults with relapsed or refractory (r/r) CD19+ hematologic malignancies. The objectives of this study are to evaluate the safety, preliminary efficacy, pharmacokinetics, immunogenicity, and pharmacodynamics of SYNCAR-001 + STK-009. Dose escalation follows a standard 3+3 design with STK-009 being escalated while SYNCAR-001 is held at a single fixed dose. A dose extension will enroll a cohort of patients treated at a selected dose level and indication based on dose escalation findings. SYNCAR-001 is dosed intravenously (IV) once at Day 0 and STK-009 is dosed subcutaneously (SC) over the course of the study. Participants receive a single safety lead-in dose of STK-009 prior to lymphodepletion and subsequent SYNCAR-001 infusion. After SYNCAR-001 initiation, STK-009 is dosed SC weekly for 12 weeks and then monthly for 3 months. Eligible participants include individuals with r/r chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and selected r/r B-cell non-Hodgkin lymphoma (NHL subtypes of large B cell, mantle cell, and indolent lymphoma). Prior CD19 CAR use is excluded. The primary endpoint of safety includes outcomes such as adverse events and dose-limiting toxicities. Secondary endpoints include assessments of response, pharmacokinetics, and immunogenicity. Exploratory endpoints include assessment of immune cell populations, and relevant gene/protein expression, as well as persistence, phenotype, and functionality of SYNCAR-001 in the peripheral blood and/or bone marrow in response to STK-009. Citation Format: Maria Lia Palomba, Matthew G. Mei, Paolo F. Caimi, Matthew Cortese, Marco Davila, Greg Yadnik, Nestor Huang, David Mou, Martin Oft, Paul-Joseph Aspuria, Anita Mehta-Damani, Navneet Ratti, Naiyer Rizvi, Alex Azrilevich, Ran Reshef. A Phase 1 study to evaluate the safety and tolerability of a combination autologous CD19 CAR T cell therapy (SYNCAR-001) and orthogonal IL-2 (STK-009) in subjects with relapsed or refractory CD19 expressing hematologic malignancies (NCT05665062) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr CT125.