Objective: to provide a comparative assessment of the use of artificial intelligence technologies by organizations in the context of Russian regions and to identify determinants of their dynamics. Methods: descriptive statistics, histogram, grouping, principal component method, panel data models. Results: an absolute trend of recent years is to study and implement artificial intelligence technologies in many economic, industrial processes and social life. The article analyzes the trends in the application of artificial intelligence technologies in the Russian regions. The comparative analysis of regions by the level and growth rate of artificial intelligence technologiesuse by organizations showed that the regions were heterogenous by the dynamics of this indicator in 2020-2022. The regions were divided into four groups: above average and below average level in Russia. Econometric modeling based on the method of principal components gave grounds to unite the determinants of the use of artificial intelligence technologies into four components. Panel data fixed-effects models showed a significant impact of the component, characterizing the state of human capital, the level of economic development, and innovation activity of organizations in the region. Scientific novelty: for the first time an attempt was made to provide a comparative analysis of Russian regions by the level of artificial intelligence technologies use by organizations and to find the determinants of its change. Practical significance: the heterogeneity of regions in terms of the artificial intelligence technologies use by organizations was substantiated, as well as a great impact of the specific characteristics of regions, which should be taken into account when building a national policy of artificial intelligence development.