Background: Acceptance, interest, and demand for Complementary Integrative Medicine (CIM) has been steadily growing within the US. Yet despite increased use, patient non-disclosure and physician lack of comfort in discussion is common. Medical students (MS) express interest in CIM. Educational exposure affects attitudes, cultural competence, interprofessional education, knowledge, and clinical skills. A few studies include US MS; however, most studies have been done outside the US. Aims: Our study examined first year US allopathic MS knowledge, perception, and attitudes toward IM for patient care, current personal use, and modalities of interest. Methods: The study was conducted on first year MS from 2020-2022 who participated in a 3-hour IM session within the required Essential Principles of Medicine course at a US allopathic medical school. Five questions were disseminated through Poll Everywhere during a lecture given by an IM board certified physician and students were invited to respond. Questions assessed student definition of IM, perception of patient barriers in discussing IM, perception of physician barriers in discussing IM, personal use, and modalities of interest. Results: MS attitude toward IM was generally positive based on word choice. MS perception of patient barriers in discussing IM focused on emotional factors rather than knowledge and understanding, whereas medical student perception of physician barriers revolved around lack of familiarity, knowledge, and training. Students self-reported physical activity and sleep as the top ranked favorite stress-reducing self-care practice followed by cooking/eating, music, and yoga. Students were most interested in exploring pet therapy, Traditional Chinese Medicine (TCM) and yoga. Conclusions: Further study with the integrative medicine attitude questionnaire (IMAQ) is recommended to determine whether results are generalizable. Integrating IM education and experience into the conventional medical curriculum is of interest to allopathic US MS and may prepare students for optimizing future patient care as well as clinician wellness.