Adrcnocortical and gonadal functions were studied in a 24-year-old patient with testicular feminization. The control values for plasma 17-hydroxycorticosteroids, urinary formaldehydrogenic steroids and urinary pregnanetriol were normal. The urinary excretion of 17-ketosteroids and pituitary gonadotropins fluctuated at the upper range of normal for males, while the urinary excretion of estrogens was high for a male of comparable age. Fractionation of the urinary 17-ketosteroids revealed normal quantities of etiocholanolone, androsterone, and 11-oxygenated 17-ketosteroids, and only small quantities of dchydroepiandrosterone. The administration of ACTH resulted in the usual increase in the level of plasma 17-hydroxycorticosteroids and all urinary steroids except dchydroepiandrosterone. Administration of dexamethasone resulted in a fall in the level of plasma 17-hydroxycorticosteroids to nearly zero, but the urinary excretion of 17-ketosteroids remained appreciable and averaged 12.5 mg. per twenty-four hours....