Existing ventilation technologies often struggle to balance the limited airflow supply with the demands of indoor ventilation and air circulation in winter. This paper introduces a novel ventilation method, vertical single-row inclined slit ventilation (VSISV), which channels airflow through multiple inclined slits spaced at specific intervals along a vertical supply air duct. By ensuring continuity of the upstream and downstream slit jets, a continuous downward airflow is formed, enhancing both winter ventilation performance and indoor air circulation. The method was experimentally measured, with a focus on comparison to the IJV system. At the same airflow rate, it not only efficiently transports the supply air heat from the upper indoor area to the floor but also exhibits strong horizontal diffusion capability. The RNG turbulence model was selected for numerical simulation, focusing on indoor thermal comfort, air quality, and energy-saving potential. The results indicate that, at the same airflow rate, this method effectively maintains high indoor thermal comfort, directs airflow downward from the ceiling, reduces thermal stratification in the upper zone, achieves a more uniform and elevated indoor temperature, enhances indoor air quality, and demonstrates substantial energy-saving potential. This provides valuable insights for energy conservation, emission reduction, and the optimization in winter building ventilation systems.