We scrutinize the numerically investigates entropy generation for unsteady magnetic nanofluid with stagnation region of an impulsively rotating sphere with viscous dissipation and chemical reaction effects. Employing the similarity technique, the equations modeling are switched into highly nonlinear differential equations with boundary layer flow. These equations are numerically executed with bivariate spectral quasilinearization method. The entropy generation effect of varying various pertinent different parameters are taken into account and the results analyzed graphically. The rate of entropy generation and energy related temperature profiles increased with increased of thermal radiation parameter, chemical reaction and rotation parameters while increased values of the magnetic number had a negative impact impact on rate of entropy generation. Variables of engineering interest which includes the skin friction coefficient, the Nusselt number and the Sherwood number were also analyzed in a table. These numerical results will be of great value to chemists, biologists, physicists, and engineers interested in the theory and applications of entropy generation.