Industrial processes often involve a long time delay, which adversely affects the stability of closed-loop control systems. The traditional Smith Predictor (SP) is a model-based controller used in processes with large time delays. The variation of system parameters and load disturbance situations are disadvantages of the traditional SP, and researchers have, therefore, proposed modified SP structures. In this paper, a design method based on the direct synthesis approach on a modified SP structure is discussed. In the design, an I-PD controller structure is used on the set-point tracking side of the SP, and a cascading PD lead–lag controller is used on the disturbance rejection side. In contrast with other studies in the literature, the use of simpler controllers enables the mathematical expressions that arise in the direct synthesis method to be significantly reduced. The proposed method is examined under the disturbance input effects for normal and parameter-changing conditions on system models with unstable second-order plus time-delay processes. The first plant model has two unstable poles, the second has one stable and one unstable pole, and the third has one unstable and one zero pole. When the results obtained using the proposed method were compared with other methods, significant improvements were achieved in terms of set-point tracking, disturbance rejection, and robustness conditions.