This paper reports on the Knowledge, Attitude and Practices regarding Sexually Transmitted Infections among post-secondary students in faith-based institution and public institutions. A survey was administered to select three different universities and over 700 participants were selected randomly. The survey included outcome measures including biodata and socio-economic status, moral and religious beliefs, sex and sexuality, STI knowledge and screening. The students responded range in age from 15 to 27+ years old and include freshmen, sophomores, juniors and seniors. Most respondents (86%) were female and aged 19-22 years old (88%). The respondents self-reported as Muslim (66%) or Buddhist (34%) and as conservative (29%), moderate (66%) or liberal (5%). Although 55% and 97% of respondents reported that there were sexual health discussions at their university, and their university had programs that teach about the pros and cons based on religion, respectively, over 82% report that they are still curious about sex and STI. Almost all students (97%) know what an STI is and can correctly identify the most publicized STIs. A large number (24%) failed to select genital warts as an STI. However, their attitudes about sexual relationships suggest unsafe sexual behavior. Almost half of the respondents think that one must have sex more than one time to catch an STI. Overall 34% say sex is ok as long as it does not lead to an STI or pregnancy and 51% said that promoting safe sex is more important than promoting abstinence. Some respondents also have some falsely held beliefs such as STIs can be spread by touching (26%) and insects (27%). This study concludes that Knowledge about sexually transmitted infections and programs delivered at tertiary institutions surveyed do not reduce risky behavior among the students. New methods of equipping students with knowledge and greater access to confidential advice and counselling may bring about better integration of awareness and knowledge to student lifestyle.