The COVID-19 pandemic represents far-reaching health threats, consequently, some governments took extraordinary measures where the main guidelines included social confinement and suspension of school presential activities, resulting in changes in habitual practices of university students such daily energy expenditure and food intake. PURPOSE: To determine the changes on daily energy expenditure and food intake in 10 health sciences university students after 6-month isolation by COVID-19 pandemic. METHODS: Anthropometric parameters, a daily physical activity questionnaire, and a nutritional survey were obtained one week before the isolation by COVID-19 pandemic and after 6-months of confinement. Changes of body mass index, daily energy expenditure, and daily energy intake (daily total calories, total protein, total lipids, and total carbohydrates) were compared before and after the study period. RESULTS: The main outcomes are described in Table 1. CONCLUSIONS: Confinement by COVID-19 in university students showed a decrease in health status due to increased consumption of calories, specifically lipids, which results in an increase in body mass index, impacting in a greater risk of being affected by the coronavirus, in addition to being one of the main risk factors for suffering from cardiovascular diseases. Finally, even though there didn’t exist statistical difference, there can be appreciated a tendency to decrease daily energy expenditure.