Purpose: This study was conducted to investigate the correlation between stress and adjustment to college life among nursing students. Methods: The sample consisted of 183 university students in C & S cities. Self-report questionnaires were used to measure the variables. In data analysis, SPSSWIN 23.0 program was utilized for descriptive statistics, Pearson's correlation coefficients, and regression analysis. Results: The mean scores of stress and adjustment to college life were 2.55 and 3.24. Stress was significantly different according to grade (F=7.30, p<.001), economic state (F=14.39, p<.001), perceived health state (F=6.66, p<.001). In regression analysis, stress for college life, perceived health state, and college life satisfaction were significant predictors of adjustment to college life explaining 68%. Conclusion: This study suggests that perceived health state was a significant factor on adjustment to college life among nursing students. Therefore, the strategies of nursing intervention which improve perceived health state must be developed for college students.