Universitas Muslim Indonesia Research Articles

KNOWLEDGE ATTITUDE AND PERCEPTION OF HYPERTENSION AMONG STAFF OF A TERTIARY INSTITUTION IN NIGERIA

Background: Hypertension was a prevalent disease in developed countries, but has recently become a major disease of public health importance in developing countries. Objective: Study assessed knowledge, attitude, and perception about hypertension among the staff of University of Port Harcourt, Rivers State. Method: Cross- sectional study was conducted among the staff in July 2019. 256 staff was randomly selected across all the Faculties. Data collected using structured questionnaire include, demographic information, knowledge, perception and attitude about hypertension and statistical analysis carried out with SPSS version 20 Result: Total 54.7% (140) respondents were academic staff and 45.3% (116) non- academic. 61.7% (158) male, females constitute 38.3% (98). Male academic staff was 67.1% (94); most academic staff, 36.4% (51) was within 50-59 years, 28.6% (40) were between 40-49 years. Total 37.1% (43) non-academic staff were within 40-49yrs. Respondents have a good knowledge, 87.9%, of hypertension, but only 61% (85) of academic and 47% (54) non-academic staff knew that hypertension can be inherited. Total 40% (56) academic, 44.8% (52) non-academic claimed to have multiple source of information about hypertension. Knowledge on risk factors of hypertension was poor, 20%. Conclusion: Knowledge level of respondents on hypertension was high, with moderate attitude but poor perception. Peer Review History: Received: 12 January 2022; Revised: 23 February; Accepted: 1 March, Available online: 15 March 2022 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indonesia, ahmad.najib@umi.ac.id UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Md. Monirul Islam, Department of Pharmacy, Faculty of Health Sciences, Northern University Bangladesh, Dhaka, Bangladesh. monirul.islam@nub.ac.bd Rola Jadallah, Arab American University, Palestine, rola@aauj.edu Similar Articles: PATTERN OF ANTI-HYPERTENSIVE DRUGS IN A TERTIARY CARE HOSPITAL IN KERALA AND ADHERENCE TO JNC-8 GUIDELINES SOCIOECONOMIC STATUS EFFECT ON MANAGEMENT OF HYPERTENSION IN COMMUNITY PHARMACY IN SOUTH- SOUTH ZONE IN NIGERIA

THE CYTOTOXICITY ACTIVITY OF ETHANOLIC EXTRACT OF ACANTHUS ILICIFOLIUS L LEAVES USING BRINE SHRIMP LETHALITY TEST (BSLT) METHOD

Aim and objective: Acanthus ilicifolius also known as jeruju is a plant that has a lot of bioactivity that can be used as a potential medicinal plant development. This study aimed to determine the cytotoxicity activity of ethanol extract of A. ilicifolius leaves. Methods: This study used Brine Shrimp Lethality Test (BSLT) method using Artemia salina larvae with test solution series concentration of 10, 50, 100, 500, 1000 ppm and control without extract. A. salina was added to each test tube. After 24 hours, the larvae mortality was observed. LC50 assessment was analyzedwith probit analysisby Microsoft excel. Result: The largest mortality percentage was shown at a concentration of 1000 ppm ethanol extract of A. ilicifolius leaves with an average mortality value of 80%, while the concentrations of 10 ppm, 50 ppm, 100 ppm, and 500 ppm had an average mortality value of 20%, 40%, 57% and 63%.The ethanol extract of A. ilicifolius leaves categorized as toxic with a LC50 value of 103,6 ppm. Conclusion: It was concluded that ethanol extract of A. ilicifolius leaves has cytotoxicity activity potential. Peer Review History: Received: 11 January 2022; Revised: 12 February; Accepted: 3 March, Available online: 15 March 2022 Academic Editor: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt, gehankandeel9@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com Similar Articles: ANTIFUNGAL, CYTOTOXIC AND PHYTOTOXICITY OF AERIAL PART OF RANUNCULUS MURICATUS CYTOTOXIC EFFECT AND PHYTOCHEMICAL STUDY OF PETROLEUM ETHER EXTRACT OF TILIA CORDATA MILL

Pembelajaran Berbasis Multimedia Interaktif Mahasiswa Di Perguruan Tinggi

Education and Learning Journal (ELJour) is a Journal published by the departement of Education, Faculty of Islamic Religion, Universitas Muslim Indonesia. ELJour is an open-access journal which has been established for the dissemination of state-of-the-art knowledge in the field of education, learning and other matters relating to education such as: Islamic Education, Curriculum and teaching methodology, Contemporary issues in education and learning, Development in education and learning, Education and learning technology, Education and learning research, Educational Psychology, Innovations in education and learning, Management Education, Special Education, and, vocational education.

CHARACTERIZATION OF PARTIALLY PURIFIED TYROSINASE ISOLATED FROM BITTER KOLA (GARCINIA KOLA)

Objective: Tyrosinase is a glycosylated, copper-containing oxidase that catalyzes the first two steps of mammalian melanogenesis as well as enzymatic browning events in damaged fruits during post-harvest handling and processing. Human skin hyperpigmentation and enzymatic browning in fruits are both undesirable. In this study, the properties and inhibitory effect of some compounds on bitter kola tyrosinase were investigated. Methods: Bitter kola tyrosinase was isolated and characterized using standard protocols. Partial purification was carried out on Sephadex G-100 loaded column chromatography. Results: Bitter kola tyrosinase was purified with a specific activity of 3.5 U/mg protein, purification fold of 2.4 and a yield of 34%. The optimum pH value was found to be 6.0 while the optimum temperature value for maximum enzyme activity was observed at 60°C. The enzyme was stable at 40oC for 20 minutes. Metals such as NaCl, KCl, MgCl2 and CaCl2 had inhibitory effect on the activity; though MgCl2 and CaCl2 had minimal effect. Also, EDTA, β-marcaptoethanol and glutathione greatly inhibited the enzyme activity at all the tested concentration. Conclusion: The properties of bitter kola tyrosinase compare very well with the tyrosinase from other sources. Also, the study was able to establish the inhibitory effect of some compounds and this could be applied in food processing industries. Peer Review History: Received: 2 November 2021; Revised: 11 December; Accepted: 25 December, Available online: 15 January 2022 Academic Editor: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Dr. Nazim Hussain, North East Frontier Technical University, Arunachal pradesh, India, nhussain116@gmail.com Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com Similar Articles: PHYTOCHEMICAL PURIFICATION OF ACTIVE CONSTITUENTS ISOLATED FROM ROOT OF THE MEDICINAL HERB, CARALLUMA QUADRANGULA

THE POSSIBLE ROLE OF TRACE ELEMENTS IN THYROID HYPERTROPHIC AND ADENOMATOUS TRANSFORMATION

Background: Thyroid benign nodules (TBNs) are the most common diseases of this endocrine gland and are common worldwide. Among TBNs the colloid goiter (CG) and thyroid adenoma (TA) are very frequentdiseases. Evaluation of variant of TBNs is clinically important for subsequent therapeutic interventions, as well as for a clearer understanding the etiology of these disorders. The aim of this exploratory study was to examine differences in the content offifty trace elements (TE) in CG and TA tissues. Methods: Thyroid tissue levels of TE have prospectively evaluated in 46 patients with CG and 19 patients with TA. Measurements have performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides (INAA-LLR) and inductively coupled plasma mass spectrometry (ICPMS), respectively. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for TE analysis. Results: It was observed that in both CG and TA tissues the contents of Ag, Al, Cr, Hg, Mn, Th, and Zn increased, whereas the levels of Au, Be, Cs, Pb, Rb, Sb, Sc, Th, Yb, and Zr were unchanged in comparison with normal thyroid tissue. No differences were found between the TE contents of CG and TA. Conclusions: From results obtained, it was possible to conclude that the common characteristics of CG and TA tissue samples were of a high level of Ag, Al, Cr, Hg, Mn, Th, and Zn in comparison with normal thyroid and, therefore, these TE could be involved in etiology and pathogenesis of thyroid disorders such as CG and TA. Peer Review History: Received: 12 November 2021; Revised: 15 December; Accepted: 31 December, Available online: 15 January 2022 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indonesia, ahmad.najib@umi.ac.id UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Rima Benatoui, Laboratory of Applied Neuroendocrinology, Department of Biology, Faculty of Science, Badji Mokhtar University Annaba, BP12 E L Hadjar–Algeria, benattouiryma@gmail.com Similar Articles: COMPARISON OF LEVELS OF TWENTY CHEMICAL ELEMENTS IN NORMAL THYROID TISSUE AND HYPERTROPHIC THYROID TISSUE

IN VITRO GENOTOXICITY OF THREE PLANTS FROM ASTERACEAE FAMILY IN HUMAN LYMPHOCYTES CULTURES

Background: Onopordum carduiforme, Centaurea verutum, and Achillea santolina are medicinal plants grown in Syria and commonly used in traditional medicine. Such as antibacterial, antioxidant and anticancer properties. However, the genotoxic effects of these plants have not been studied. Aim and objective: the aim of this study was to evaluate the genotoxic effects of hydroethanolic extracts of these plants on human lymphocyte cultures model by evaluating the cell proliferation, determination of mitotic index (MI), and their effects on chromosomes. Methods: the hydroethanolic extracts of the aerial parts of the three plants were extracted using an Ultrasonic bath. Then the genotoxic effects of hydroethanolic extracts of these plants on human lymphocyte cultures was conducting by determination of mitotic index (MI). Results: the results showed that all three plants decreased non-significantly the mean of mitotic index in comparison with negative control (normal MI) (p>0.05) at concentrations (1, 3, 5 mg/ml) and the mitotic index values ranged was between (2.25±0.07 and 3.3±0.28). However, C. verutum showed the lowest mitotic index (3±0.14 at 1 mg/ml) and (2.25±0.07 at 5 mg/ml), and did not induce chromatid or chromosome breaks or gaps. Conclusion: these preliminary results on cytotoxicity and mutagenicity of these plants provide valuable information about the safety of using them in alternative medicine. Peer Review History: Received: 11 November 2021; Revised: 13 December; Accepted: 28 December, Available online: 15 January 2022 Academic Editor: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id Dr. Dennis Amaechi, MrsFoluBabade Mini Estate , Flat 5 by Old Soldiers Quarter, Sabongari/Bwari, Abuja- Federal Capital Territory, Nigeria. amaechitoexcel@yahoo.com Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my Similar Articles: A STUDY ON DIFFERENT PLANTS OF APOCYNACEAE FAMILY AND THEIR MEDICINAL USES STUDY LITERATION OF CHEMICAL CONTENTS OF SOME PLANTS THAT POTENTIALLY AS THE SOLAR SOWS EXPLORING THE ANTIPARASITIC ACTIVITY OF MEDICINAL PLANTS

Use of sulfate-reducing bacteria and different organic fertilizer for bioremediation of ex-nickel mining soils

The microbiological activity associated with exmining soil remediation can be considered useful to accelerate the contaminant degradation. The use of sulfate-reducing bacteria (SRB) and organic matter exhibits potential in improving ex-nickel mining soil quality. The purpose of this study was to examine the ability of SRB in several organic fertilizers to reduce sulfate and nickel ions, and to increase pH of soil from nickel in mining areas. This study used the bacteria collection of the Soil Laboratory of the Faculty of Agriculture, Universitas Muslim Indonesia. Those were previously isolated from two cultivating pond of milkfish in the Kuri area of Maros Regency, South Sulawesi, Indonesia. The soil samples were collected from ex-mining areas of the Vale Indonesia Enterprise in Soroako, South Sulawesi, Indonesia. Those were mixed with organic fertilizers, generated from sugarcane sludge, manure, and Quickstick (Gliricidia sepium) leaves, each with 50 and 100 g doses. The 5 kg soil samples were put into a pot and mixed evenly with organic fertil- izers. A general linear model (GLM) repeated measures analysis of variance (ANOVA) was adopted to analyze the data. The results of this study indicate that the application of SRB and fertilizer was effective in reducing concentration of sulfate and nickel. Among the three types of organic fertilizers, manure was effective in reducing sulfate and nickel concentrations, while Quickstick fertilizer was the more effective in stabilizing pH level. Fertilizer doses exhibited a significant effect on decreasing sulfate and nickel concentrations, but it exhibited no significant effect on stabilizing pH levels. At 10 days after treatment (DAT), the sulfate concentration decreased from 2,530 ppm to 1,443 ppm in treatment of SRB and manure with dose of 50 g and 1,363 ppm with that of 100 g. At the end of the observation (30 DAT), those were decreased to 1,217 ppm in treatment of SRB and manure with doses of 50 g and 1,167 ppm with that of 100 g. Among the three types of organic fertilizers used, Quickstick demonstrates the more effective reduction rate. At 10 DAT, pH increased in SRB treatment by 7.06 at a concentration of 50 g and 7.01 at a concentration of 50 g. At the end of the observation (30 DAT), the pH became 6.67 at a concentration of 50 g and 6.82 at a concentration of 50 g. The nickel concentration decreased from an origin concentration to 1,950 ppm in treatment of SRB and manure with doses of 50 g and 1,690 ppm with that of 100 g. Thus, the application of manure fertilizer and the addition of SRB is recommended for bioremediation of sulfate and nickel from ex-mining soil.

Preface

Welcome to The 2020 International Conference on Science in Engineering and Technology (ICoSiET), online held 21-22 October, 2020. The 2020 International Conference on Science in Engineering and Technology (ICoSiET) is an international conference which covers Science and applied engineering and technology. ICoSiET 2020 will be held on October 21-22, 2020 in Palu, Indonesia. This conference hosted by Universias Tadulako and is jointly organized with Association for Scientific Computing Electronics and Engineering (ASCEE), Universitas Islam Alauddin Makassar, Universitas Negeri Malang, Universitas Mulawarman, Universitas Muslim Indonesia, and Universitas Lambung Mangkurat. This conference is IOP conference so that papers accepted and presented will be forwarding for consideration to be published in the IOP Material Science and Engineering. Thanks are due to Keynote Speakers, Prof. Dr. Zhen-jiang Shen (Faculty of Geosciences and civil Engineering, Institute of Science and Engineering Kanazawa University, Japan), Prof. Dr. Richard Sliuzas (Department of Urban and Regional Planning and Geo-Information Management Twente University, Netherland), Prof. Yandi Andri Yatmo., Ph.D (Department of Architecture Faculty of Engineering Universitas Indonesia, Indonesia). Prof. Amar Akbar Ali (Department of Architecture Universitas Tadulako, Indonesia), and Dr. Diana Contrias Mojica, New Castle University, UK)This year, the ICOSIET conference received 110 papers submissions from 106 countries such as, Bangladesh, China, Colombia, Germany, Hong Kong, India, Indonesia, Iraq, Japan, Jorda, Peru, Philippines, Russia, Saudi Arabia, Thailand, United Kingdom, United States and Viet Nam. But only 68 papers were accepted for presentations for online sessions (the acceptance ratio is 65%). We are very grateful for the extensive efforts of many individuals who worked diligently to ensure a successful and high quality conference. We would like to thank to IPO, ASCEE, TPC Committee and Faculty of Engineering Tadulako University for supporting this event.Once again we would like to say Welcome to ICOSIET 2020. Congratulations for your papers have been accepted. We invite all participants to actively participate in the conference activities to learn from one another. Thank you for choosing ICOSIET as your conference reference. We hope to have your pleasant supports and participations in the next year 2021 7th ICOSIET.List of ICoSIET 2020 Committee, ICoSIET 2020 Editors are available in this pdf.

Service room design for improving service quality of Utsman bin Affan library Universitas Muslim Indonesia with Kansei Engineering approach

Service room design for improving service quality of Utsman bin Affan library Universitas Muslim Indonesia with Kansei Engineering approach

Service room design for improving service quality of Utsman bin Affan library Universitas Muslim Indonesia with Kansei Engineering approach

A student can study well if there is a good place to study as well. Likewise with reading, a person needs concentration to read. Service room design is necessitated in the reading room because it affects one’s reading comfort. Utsman bin Affan library UMI Makassar is a place for students to study. Students’ complaints and problems that are experienced when using the library service room are in the form of uncomfortable facilities, no closed rooms, and other complaints. In reference to these problems, a study was carried out in accordance with the students’ complaints by employing Kansei Engineering approach. Kansei Engineering is a consumer-oriented ergonomic technology which enables the consumer’s image or feeling to unite with the service design process of a product. By utilizing this method, product strategy and concept creation in the design of a product or service can be determined. The final results of Utsman bin Affan UMI Makassar library service room which was obtained based on the Kansei Engineering method are an open service room, large display, reading room, multimedia room, collection room, green and white colors, 3D motif and glossy texture. In addition to the main specifications of the library, there is also an additional item supporting the service room, which is a partition made of glass that gives the impression of being open to the room although it is still divided into different spaces.

Pengolahan Berbagai Produk Berbahan Baku Ikan pada Kelompok Mitra Desa Binaan UMI

Abstract Purpose: The aim of designing this PkM is to increase and develop the potential and economic capacity of the community, particularly in the villages that have received assistance from the Universitas Muslim Indonesia, to improve the overall well-being of the community. It is necessary to achieve business independence while also opening up new employment opportunities for the family economy to undergo fundamental transformations. Another objective is to increase income and improve the well-being of rural communities during the period of recovery from the COVID-19 pandemic's economic impact. Method: The method is carried out by providing socialization to housewives who are members of the Family Empowerment group of partner villages, processing assistance to making products made from fresh fish produced from natural resources in Desa Padingging, Kabupaten Takalar. Results: The products are widely distributed, both in grocery stores backed by BUMDes and in traditional markets, as well as in the process of entering the Makassar souvenir shops that are characteristic of the city. Conclusions: To promote the use of natural resources in Takalar Regency, which is rich in natural resources and particularly abundant in fresh fish, socialization activities relating to their utilization have been carried out. This is done to maximize the economic potential currently available for the production of superior processed fish products. As a result of the activities that have been carried out, it is expected that housewives and partner villages supported by Universitas Muslim Indonesia will be able to earn a living independently.

The Effectiveness of Online Learning at English Education Students

Online learning is one of the alternative learning media specially made for lecturers and students of the Universitas Muslim Indonesia in carrying out the teaching and learning process during the COVID-19 pandemic, but its effectiveness is still questionable. This is what motivated the researcher to conduct research on the effectiveness of online learning. This study aims at determining the effectiveness, advantages, and disadvantages of online learning for English Education students Faculty of Letters Universitas Muslim Indonesia during the Covid 19 pandemic. The method used in this study was a mixed, quantitative, and qualitative method. The population in this study was students of the English Education Faculty of Letters Universitas Muslim Indonesia and the research sample was 41 students. To collect data, the researcher used a questionnaire in the form of a google form and used proportional stratified sampling in determining the research subject. The results of this research lead to evidence that online learning can help English Education students Faculty of Letters Universitas Muslim Indonesia attend lectures whenever and wherever they are.

APPLICATION OF LUTEIN-ZEAXANTHIN OF EGG YOLK BASED HYDROGEL EYE MASK AS A PREVENTIVE EFFORT AGAINST COMPUTER VISION SYNDROME (CVS)

Aims and objectives: Computer Vision Syndrome(CVS) is a collection of symptoms related to eye disorders due to the use of computer-based digital devices. So substantial protection is needed against damage caused by exposure to blue light by digital devices. Lutein and zeaxanthin are carotenoids that contain antioxidants so that they can overcome inflammation, have a calming effect and can maintain eye health. The purpose of this research is to produce a topical preparation in the form of a hydrogel eye mask from egg yolk which is useful for overcoming Computer Vision Syndrome(CVS).
 Methods: This study formulated three formulas with the active ingredients of egg yolk extract 400µg, 600µg and 800µg using 8.75 g of sodium alginate base and 3.75 g of xanthan gum. Evaluation of the preparations included organoleptic tests, weight and size, pH, swellability, shrinkage, homogeneity, viscosity, spreadability, adhesion and stability tests.
 Results: of the evaluation of the preparations hydrogel eye mask in the three formulas showed good physical characteristics and stability. The results of the evaluation that have been carried out show that the organoleptic test has no changes in color, odor and shape. Test the appropriate weight and size under the eye area. The pH test of the three formulas before storage was 7.3±0.15, 7.1±0.05, 7.1±0.17 and after storage 7.5±0.1, 7.4±0.1, 7.2±0.2. The expansion and shrinkage test showed an increase in weight every hour and a decrease in weight every 10 minutes. The homogeneity test showed the three formulas were homogeneous. The viscosity test is in a good range. The dispersion test of the three formulas before storage was 5.13±0.2, 5.07±0.15 and 5.18±0.28 cm and after storage was 5.05±0.13, 5.20±0.32, and 5.11±0.22 cm. The adhesion of each formula before storage was 4.23±0.51, 3.27±0.84, 3.28±0.62 seconds and after storage 3.24±0.38, 3.26±0.15, 2.96±0.77 seconds.
 Conclusion: The three formulas produced have good pharmaceutical characteristics and stability so that they can be used to treat Computer Vision Syndrome (CVS).
 
 Peer Review History: 
 Received: 5 September 2021; Revised: 8 October; Accepted: 25 October, Available online: 15 November 2021
 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indones
 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. 
 Received file: Reviewer's Comments:
 Average Peer review marks at initial stage: 5.0/10
 Average Peer review marks at publication stage: 7.0/10
 Reviewers:
 Dr. Mohammad Bayan, Faculty of Pharmacy, Philadelphia University, P.O. Box: 1 Philadelphia University 19392 Jordan, mbayan01@qub.ac
 Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com
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ANALYSIS OF BIOFILMS FOR STREPTOCOCCUS MUTANS FROM DENTAL ROOT SURFACES OF ADULT PATIENTS WITH ROOT CARIES

Background and objectives: Knowledge of the pathogenicity of the primary etiological factor of root caries, the microbial biofilm, might provide important information for the development of diagnosis and treatment strategies. This study assessed the numbers and revealed the proportion of Mutans streptococci , which is potential important cariogenic organisms, in biofilms collected from lesions at root surfaces with active caries lesions (ARC), inactive caries lesions, and sound root surfaces (SRS).
 Material and methods: Samples were cultured in MSB agar for Mutans streptococci counts, and brain-heart infusion agar for total viable anaerobic counts. After incubation, the number of colony-forming units (CFUs) was determined and compared between groups by the Mann-Whitney U test with a significance level set at 95%. The proportion of counts of Mutans streptococci in the total viable microorganisms was also analyzed by Chi-square test. 108 samples (36 from each surface) from 36 patients were cultured and analyzed.
 Results: The mean±SD for the counts of active root caries lesions was 7.47±9.89 10, significantly higher than that of inactive root caries lesions (2.5±0.97) and sound root surfaces (3.03±0.71). In conclusion, a trend towards higher counts was evident for ARC. In the ARC lesions among the dominant oral anaerobic bacteria, we could not identify streptococcal colonies (unspecified) in 11% while in IRC lesions it occurred in 47%, and SRS it occurred in 47%. In addition, in ARC the samples were ≥0.1-≥10 (CFU x10) ≥0.1-≥10 colonies of Streptococcus mutans.
 Conclusion: In conclusion, a trend towards higher counts was evident for ARC and for most samples, the proportion of Streptococcus mutans was low relative to the viable number of total viable anaerobic microorganisms.
 
 Peer Review History: 
 Received: 5 September 2021; Revised: 10 October; Accepted: 24 October, Available online: 15 November 2021
 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indones
 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. 
 Received file: Reviewer's Comments:
 Average Peer review marks at initial stage: 6.0/10
 Average Peer review marks at publication stage: 7.0/10
 Reviewers:
 Dr. Rawaa Souhil Al-Kayali, Aleppo University, Syria, rawah67@hotmail.com
 Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg
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 CLINICAL FEATURES, AGE AND SEX DISTRIBUTIONS, RISK FACTORS AND THE TYPE OF BACTERIA ISOLATED IN PERIODONTITIS PATIENTS IN SANA'A, YEMEN

SILICA IODIDE CATALYZED ULTRASOUND ASSISTED ONE-POT THREE-COMPONENT SYNTHESIS OF 3,4-DIHYDROPYRIMIDINE-2-(1H)-ONES/-THIONES

Aim and objective: A single-pot three-component reaction for a competent preparation of biologically active 3,4-dihydropyrimidineones/-thiones using Silica Iodide (SiO2-I) as a reliable and reusable heterogeneous catalyst is developed. Methods: The reaction proceeds via condensation of araldehydes, urea/thiourea, ethyl acetoacetate in ethanol under ultrasonic condition to afford the target molecules in best yields. The reaction proceeds in 30 min and SiO2-I has shown high proficiency in performing this single-pot Biginelli reaction. Results: The use of catalytic SiO2–I (0.1 g) accelerated the reaction and gave the product in excellent yield. Maximum yield of the product was found to be 96% in ethanol Conclusion: Study concludes the used method has shown many advantages, mild condition, short duration, simple isolation and best yields of products. Peer Review History: Received: 10 September 2021; Revised: 18 October; Accepted: 02 October, Available online: 15 November 2021 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indones UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Dr. Sunita Singh, Baylor College of Medicine, Houston, Texas, USA, sunita.nccs@gmail.com Idoko Alexander, Caritas University, Enugu, Nigeria, idokoalexander1@gmail.com Similar Articles: GREEN, RAPID, SIMPLE, AND AN EFFECTIVE ONE-POT MULTICOMPONENT STRATEGY FOR SYNTHESIS OF NOVEL DIHYDROPYRANO[2,3-C]PYRAZOL-6-AMINES IN AQUEOUS MEDIUM

CELIAC DISEASE AMONG GASTROINTESTINAL PATIENTS IN YEMEN: ITS PREVALENCE, SYMPTOMS AND ACCOMPANYING SIGNS, AND ITS ASSOCIATION WITH AGE AND GENDER

Background and objectives: Celiac disease is a long-standing autoimmune illness that principally affects the small intestine. Typical symptoms comprise digestive problems such as chronic diarrhea, flatulence, malabsorption, loss of appetite, and failure of children to grow normally. The prevalence of celiac disease has not been established in Yemen, either in the general population or in symptomatic patients. Therefore, the current study aimed to assess the prevalence of disease in symptomatic patients and to investigate associated symptoms and signs; and whether prevalence of CD varies greatly between different ages and genders in a hospital in Sana'a. Methods: A cross sectional study based on the results of serological markers; IgA anti-tissue glutaminase and small bowel biopsies of 600 patients with gastrointestinal symptoms who were all patients who attended in the research period. Data were collected from hospital records during the period from March 2014 to December 2018. 600 suspected patients (245 males and 355 females) were subjects and the mean age of ±SD patients was 30.6±14.5 years (range 2-92 years). Results: The prevalence of CD among patients with gastrointestinal symptoms was 9.2%. There was a significant association between CD with females (rate being 11.3% , OR=1.9, p=0.03), and 2-19 years age group (21.4% , OR=4.3, p<0.001), Considering the clinical signs and symptoms there was a significant association between celiac disease and chronic diarrhea (OR=18.4), steatorrhea ( OR=9.6), foul odor (OR=8.3), weight loss (OR=5.7), anemia (OR=10.2), abdominal distension (OR=3.1), mouth ulcers (OR=7.2), abdominal bleeding (OR=13.5), diabetes mellitus I (OR=18), and hypothyroidism (OR=79.3). Conclusion: A high rate of CD was identified among gastrointestinal symptoms patients arriving at the general hospital in Sana’a, Yemen, and this demonstrates the importance of general practitioners in identifying patients with CD, especially in the absence of a medical facility for CD, and this was facilitated through the serological markers test. Peer Review History: Received: 11 September 2021; Revised: 12 October; Accepted: 29 October, Available online: 15 November 2021 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indones UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Dr. Gulam Mohammed Husain, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, India, gmhusain@gmail.com Dr. Vanina Doris Edo’o, University of Yaounde I, Yaounde, Cameroun, vanina_edoo@yahoo.com Similar Articles: THE ASSOCIATION OF ADULT MALE AND FEMALE INFERTILITY WITH CELIAC DISEASE PATIENTS IN YEMEN

Grammar Learning Strategies Practice: An Investigation of Strategies-Based Instruction Effect on Grammatical Competence

Grammar competence as an essential part in learning language has to be mastered by every language learner. Students, especially in higher education, need to possess the knowledge of grammar rules to produce academic products that maintain the grammatical aspects in every task. A new notion in learning grammar by employing grammar learning strategies becomes an alternative way for students in mastering grammar. Since many students are not aware of grammar learning strategies, the need to conduct strategies training in the classroom context is a solution. Empowered by styles and strategies-based instruction, this study aimed to determine the effect of grammar learning strategies on the grammatical competence of second semester students of Universitas Muslim Indonesia. Quasi-experimental design under quantitative research consisting of pre-test, eight meetings of treatment, and post-test was employed to compare the groups’ performance in grammar test. The data were obtained by using two kinds of research instruments: grammar test and questionnaire. In analyzing the data, this study employed the independent sample t-test and frequency of questionnaire. The result of statistical analysis showed that independent t-test which compared the students’ score on post-test revealed a value of p>0.05. It means that there was no significant difference between students taught with and without grammar learning strategies. The result yields some implications of having grammar learning strategies in classroom context. The students’ personal traits and experiences put some influences on the effect of strategies training. The duration of training also put contribution toward the students’ skills in employing the appropriate strategies in solving grammar problems.

COMPARISON OF LEVELS OF TWENTY CHEMICAL ELEMENTS IN NORMAL THYROID TISSUE AND HYPERTROPHIC THYROID TISSUE

Background: Goiter can appear as a palpable or visible enlargement of the thyroid gland at the base of the neck. If the goiter is accompanied by hypothyroidism or hyperthyroidism, it may be accompanied by symptoms of the underlying disorder, and nodular goiter (NG) is a health problem of international importance. The aim of this exploratory study was to assess whether there were significant changes in thyroid tissue levels of twenty chemical elements (ChE) Al, B, Ba, Br, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn , Na, P, S, Si, Sr, V, and Zn are present in the goitrous transformed thyroid. Methods: Thyroid tissue level of twenty ChE was prospectively evaluated in 46 patients with NG and 105 healthy populations. The measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis and inductively coupled plasma atomic emission spectrometry, respectively. Tissue samples were divided into two parts. One was used for morphological study while the other was for ChE analysis. Results: It was found that contents of Al, B, Br, Cl, Cu, Fe, Li, Mg, Mn, Na, P, S, Si, V, and Zn are significantly higher while the I levels are lower in NG than in normal tissues. Conclusion: There are considerable changes in ChE contents in goitrous tissue of thyroid. Thus, it is reasonable to assume that the levels of these ChE in thyroid tissue can be used as NG markers. However, this topic needs additional studies. Peer Review History: Received: 19 July 2021; Revised: 11 August; Accepted: 4 September, Available online: 15 September 2021 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, conyeji@oauife.edu.ng Similar Articles: VITAMIN A, RETINOIC ACID AND TAMIBAROTENE, A FRONT TOWARD ITS ADVANCES: A REVIEW

EVALUATION OF ANTICOCCIDIAL ACTIVITY OF METHANOLIC EXTRACT OF RICINUS COMMUNIS IN BROILER

Aims and Objectives: Coccidiosis is recognized as the parasitic disease which has the greatest economic impact on poultry production. The emergence of resistant strains to available drugs has become a major problem in order to treat/control coccidiosis. Botanicals can act as alternative to anticoccidial drugs. This study has therefore, been planned to evaluate both in vitro and in vivo anticoccidial activity of the plant R. communis. Methods: In in vitro trial 20, 10, 5, 2.5, 1.25 and 0.625 percent, DMSO dissolved crude aqueous methanolic extract of R. communis was used to investigate its inhibitory effect upon sporulation of oocysts. The research was done in University of Agriculture, Faisalabad, Pakistan, with the collaboration of Parasitology, Pathology and Poultry departments. In in vivo trial, the plant was used at three graded concentrations for evaluation of its anticoccidial activity in broiler birds. A total of 144 (one-day-old) broiler chicks were divided into six groups each having 24 chicks. At age of 15 days, groups I, II and III were given 4%, 5% and 6% of dried powder of R. communis respectively. Group IV was served as positive control (infected, toltrazuril treated), group V as negative control (infected, non-medicated) and group VI was serve as non-infected and non-medicated control. All groups except group VI were infected orally with 50,000 sporulated oocysts of mixed Eimeria species at 18th day of age. Result: After 7 days of inoculation, six birds from each group were slaughtered to get results on oocysts score, lesion score, relative organ weight, hematology and immunomodulatory effect. Data was analyzed by using analysis of variance (ANOVA) and group means were compared by Duncan’s multiple range tests. Conclusion: It was concluded that R. communis can be used as a prophylactic and therapeutic agent at local and regional level for the control of coccidiosis in broilers. Peer Review History: Received: 18 July 2021; Revised: 7 August; Accepted: 6 September, Available online: 15 September 2021 Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id Dr. Dennis Amaechi, MrsFoluBabade Mini Estate , Flat 5 by Old Soldiers Quarter, Sabongari/Bwari, Abuja- Federal Capital Territory, Nigeria. amaechitoexcel@yahoo.com Similar Articles: ANTI-INFLAMMATORY, ANALGESIC AND COGNITIVE ENHANCER PLANTS PRESENT IN BANGLADESH: A STUDY REVIEW

CO-ADMINISTRATION OF GOKO HERBAL CLEANSER AND PARACETAMOL: A HERB-DRUG INTERACTION STUDY

Aim: The present study aimed to evaluate the effects of co-administering paracetamol and Goko cleanserâon the liver. Method: Twenty rats divided into four different groups were used for this Study. Group one (control group) received distilled water only; Group two received paracetamol only (100mg/kg), Group three received Goko cleanserâonly (2 mL/kg) and Group four received paracetamol and Goko cleanserâconcomitantly for 3 days. Blood and liver samples were analyzed for biochemical and histopathological parameters respectively. Results: Data obtained revealed a significant decrease (p<0.05) in the levels of the liver enzymes (ALT, AST, and GGT) in the Goko cleanserâ-only group compared to control. A significant decrease in AST was also observed in paracetamol + Goko cleanserâgroup. No significant change in ALT, ALP and GGT levels in the paracetamol + Goko cleanserâgroups was observed. Results of histology examination showed normal liver tissues with normal hepatocytes, sinusoids and central vein for both treated and control groups. Conclusion: The significant reductions in the liver enzymes by observed in the Goko cleanserâ-only group indicated potential hepato-protective effects which could be due to the presence of phenolic compounds which acted as antioxidants. The short-term co-administration of paracetamol and Goko cleanserâproduced no liver toxicity. However, this is subject to further studies using pharmacokinetic analysis and also, a long-term study is strongly advocated. Peer Review History: Received: 7 July 2021; Revised: 8 August; Accepted: 7 September, Available online: 15 September 2021 Academic Editor: Essam Mohamed Eissa, Beni-Suef University, Egypt, dressamceutics@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id Dr. Dennis Amaechi, MrsFoluBabade Mini Estate , Flat 5 by Old Soldiers Quarter, Sabongari/Bwari, Abuja- Federal Capital Territory, Nigeria. amaechitoexcel@yahoo.com Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my Taha A.I. El Bassossy, Medicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt, tahachemist2008@gmail.com Similar Articles: COMPARISION OF ANTIDYSLIPIEMIC POTENTIAL OF 80 MILLIGRAMS OF FENOFIBRATED WITH 8 GRAMS OF NIGELLA SATIVA SEEDS DAILY