EVALUATION OF ANTICOCCIDIAL ACTIVITY OF METHANOLIC EXTRACT OF RICINUS COMMUNIS IN BROILER

Abstract

Aims and Objectives: Coccidiosis is recognized as the parasitic disease which has the greatest economic impact on poultry production. The emergence of resistant strains to available drugs has become a major problem in order to treat/control coccidiosis. Botanicals can act as alternative to anticoccidial drugs. This study has therefore, been planned to evaluate both in vitro and in vivo anticoccidial activity of the plant R. communis. Methods: In in vitro trial 20, 10, 5, 2.5, 1.25 and 0.625 percent, DMSO dissolved crude aqueous methanolic extract of R. communis was used to investigate its inhibitory effect upon sporulation of oocysts. The research was done in University of Agriculture, Faisalabad, Pakistan, with the collaboration of Parasitology, Pathology and Poultry departments. In in vivo trial, the plant was used at three graded concentrations for evaluation of its anticoccidial activity in broiler birds. A total of 144 (one-day-old) broiler chicks were divided into six groups each having 24 chicks. At age of 15 days, groups I, II and III were given 4%, 5% and 6% of dried powder of R. communis respectively. Group IV was served as positive control (infected, toltrazuril treated), group V as negative control (infected, non-medicated) and group VI was serve as non-infected and non-medicated control. All groups except group VI were infected orally with 50,000 sporulated oocysts of mixed Eimeria species at 18th day of age. Result: After 7 days of inoculation, six birds from each group were slaughtered to get results on oocysts score, lesion score, relative organ weight, hematology and immunomodulatory effect. Data was analyzed by using analysis of variance (ANOVA) and group means were compared by Duncan’s multiple range tests. Conclusion: It was concluded that R. communis can be used as a prophylactic and therapeutic agent at local and regional level for the control of coccidiosis in broilers. Peer Review History: Received: 18 July 2021; Revised: 7 August; Accepted: 6 September, Available online: 15 September 2021 Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id Dr. Dennis Amaechi, MrsFoluBabade Mini Estate , Flat 5 by Old Soldiers Quarter, Sabongari/Bwari, Abuja- Federal Capital Territory, Nigeria. amaechitoexcel@yahoo.com Similar Articles: ANTI-INFLAMMATORY, ANALGESIC AND COGNITIVE ENHANCER PLANTS PRESENT IN BANGLADESH: A STUDY REVIEW