This research article rigorously examines the Islamic World Educational, Scientific and Cultural Organization (ICESCO)'s Capitals of Islamic Culture Program, focusing on its profound impact on education, science, and culture. It seeks to provide a scholarly analysis suitable for academic submission. The study employs a comprehensive approach, drawing insights from official documents, existing literature, and interviews with ICESCO officials. Key highlights of the research include an exploration of the program's historical context and its influence on the Islamic world. The article conducts a comparative analysis, positioning ICESCO's initiatives alongside similar programs by the United Nations Educational, Scientific and Cultural Organization (UNESCO) and other international organizations, offering a global perspective. Furthermore, the article evaluates the achievements and experiences of the Capitals of Islamic Culture, emphasizing their substantial contributions to education, science, culture, and their alignment with the Sustainable Development Goals (SDGs). These contributions span areas such as education, innovation, sustainable communities, climate action, justice, and partnerships. While recognizing the program as a platform for promoting Islamic culture and fostering intercultural dialogue, this study sheds light on associated challenges. It underscores the importance of a robust documentation system to effectively evaluate and record the experiences of designated capitals, thereby optimizing the program's potential to highlight the diverse and rich cultural tapestry of the Islamic world. This research article offers a scholarly and scientific analysis of the Islamic World Educational, Scientific and Cultural Organization (ICESCO)'s Capitals of Culture Program, focusing on its impact on education, science, and culture while providing a comparative perspective with global initiatives. It aims to enrich academic course and deepen our understanding of this cultural program's words significance in the Islamic world.