This paper concerns a two-fluid Euler-Maxwell system for plasmas with two small parameters. We study the non-relativistic quasi-neutral limit for smooth solutions of the system in whole space R3. When the initial data are smooth and sufficiently close to constant equilibrium states, we give a rigorous justification of the limit for all time. The limit system is governed by a compressible Euler system. The proof is based on uniform energy estimates and various dissipative estimates of smooth solutions with respect to the parameters and time. A key step in these estimates is to control the quasi-neutrality of the velocities by using a projection operator.