Unfavorable Criteria Research Articles

Insurance Company Financial Performance Analysis

This study intends to examine the financial performance of insurance companies listed on the Indonesia Stock Exchange (IDX) between 2016 and 2019. This study employs the liquidity ratio, the profitability ratio, and the solvency ratio as indicators of financial performance. The sample comprises of thirteen insurance companies that are listed on the IDX and go public. The results revealed multiple findings. First, the liquidity ratio, which consists of the current ratio and the fast ratio, demonstrates fluctuations, particularly in the calculation of the current ratio. The maximum value for insurance companies with the AHAP code is 772 percent, which is included in the excellent criteria. In contrast, the insurance company with the code AMAG has the lowest value, 2%, which falls under the unfavorable criteria. The fast ratio also demonstrates positive results, with insurance companies having values greater than 1, indicating the availability of current assets to cover liabilities. The second variable is the solvency ratio, which comprises the total debt to equity ratio and the total debt to asset ratio. The insurance companies with the ASDM code have the highest total debt to equity ratio, which is 50%, indicating a solid equity-based return rate. Meanwhile, insurance companies with the AHAP code have the lowest value, 2%, indicating a weak equity-based return rate. The total debt to asset ratio is unfavorable, with insurance companies with the ASDM code having the highest value (83%) and insurance companies with the AHAP code having the lowest value (4%). Thirdly, return on assets (ROA) is used to compute the profitability ratio. ROA also fluctuates. Insurance companies with the AHAP code have the highest value, 5403%, which demonstrates the company's ability to generate exceptional returns on total assets. In contrast, insurance companies with the codes ABDA, AHAP, and AMAG have the lowest value, 6%, indicating a healthy rate of return on profits based on total assets.

Kinerja Keuangan PT. Krakatau Steel Tbk Membaik?: Tinjauan Analisis Laporan Keuangan

Financial reports are an accurate information instrument for assessing company performance for investors, companies and the public. PT. Krakatau Steel (Persero), Tbk, is the only state-owned company in Indonesia's steel industry. Thus, the company's status and performance are highly monitored by the government, investors, and the general public because it is a benchmark for the development of the steel industry. Issues related to the company's poor financial performance in several periods made the researchers aim to analyze the performance of the company's financial statements. This research aims to analyze the performance of the company's financial ratios items such as profitability, solvency, activity, liquidity, and profit growth ratios for the 2018-2021 period. The analytical method used in this study is a descriptive quantitative analysis of the company's financial ratios. The results of the study assume that the profitability ratio is in the unhealthy criteria, the liquidity ratio is assumed to be in the unhealthy criteria, the activity ratio is assumed to be in the unhealthy criteria, the solvency ratio is assumed to be in the reasonably good criteria, the growth ratio is assumed to be in the unfavourable criteria in the study period.

ANALISIS KINERJA KEUANGAN PADA KOPERASI SIMPAN PINJAM “WANITA KARYA LANGA” KECAMATAN BAJAWA KABUPATEN NGADA

The purpose of this study was to determine the financial performance of the Karya Langa Women's Savings and Loans Cooperative, Bajawa District, Ngada Regency in 2019-2021. This type of research is Descriptive Research. This research was conducted at the Karya Langa Women's Savings and Loans Cooperative, Bajawa District, Ngada Regency with the sample being the balance sheet report and remaining business results for 2019, 2020 and 2021. the results of the analysis in the balance sheet report and remaining operating results for 2019-2021 are: 1. The current ratio value from 2019 reached 227% with very good criteria, then in 2020 it reached 226% with very good criteria, and in 2021 it reached 159% with pretty good criteria. Thus the cooperative's liquidity for three years in terms of the current ratio can be declared healthy in meeting short-term debt and current assets owned by the cooperative. 2. The debt ratio in 2019 was 76.10% with unfavorable criteria; in 2020 it is 75.25% with not good criteria; and in 2021 it is 72.17% with unfavorable criteria. Thus the solvency of the cooperative for three years in terms of the debt ratio can be declared not yet solvable in fulfilling its debts. 3. The value of return on equity in 2019 was 6.77% with unfavorable criteria; in 2020 it is 1.26% with bad criteria and in 2021 it is 1.28% with bad criteria. Thus the profitability of cooperatives for the last three years has not been profitable in producing SHU.

PEMBUATAN TEPUNG TANAMAN SIKAS (Cycas rumpii) SEBAGAI SUMBER MAKANAN

Utilization of flour (carbohydrate) from the Cycas rumpi plant by the community in Amarsekaru Village, Gorom Island District, Eastern Seram Regency, according to the frequency and percentage, the results of the analysis show (1) Cycas rumpi plants are easy to obtain according to the respondents' answers 86.7% (2) Consuming keu 90.9% of respondents stated that it was safe for consumption and did not cause harm to the body (3) Only 80% of people who could make flour (carbohydrates) from the Cycas rumii plant (4) produced flour (carbohydrates) 73.3% sold it directly for their living needs, (5) From the respondents' answers, 73.3% of the people could make various types of cakes from Cycas rumii flour (6) 66.7% of the people who ate cakes made from Cycas rumii flour. The results of the analysis of the food (cake) taste test from Cycas rumpii flour showed the following: (1) The smell or smell of the food (cake) with good to very good criteria was 90.9%, (2) The delicacy of the food (cake) from Cycas rupii flour respondents' answers with very good criteria to good criteria were 81.8%, delicacy answers with quite good criteria to 18.2% unfavorable criteria. (3) The cakes taste from Cycas rumii flour with good to very good criteria was 100%, (4) The cake color with good to very good criteria was 63.6%, (5) The cake texture from Cycas rumii flour was based on good criteria to very good at 90.9%. Keywords: Flour, Cycas rumpii, Food

KINERJA APARATUR SIPIL NEGARA DALAM PENGURUSAN SERTIFIKAT TANAH MELALUI PROGRAM PENDAFTARAN TANAH SISTEMATIS LENGKAP (PTSL) DI KANTOR PERTANAHAN KABUPATEN MINAHASA

This study aims to determine and analyze the performance of state civil servants in obtaining land certificates through the Complete Systematic Land Registration Program (PTSL) at the Minahasa Regency Land Office. This research method uses a qualitative descriptive method, with research indicators consisting of quality, quantity, use of time and work commitment. Data analysis uses steps, namely data reduction, data presentation, levers or withdrawals, and data conclusions. The results showed that the performance of the state civil apparatus who took care of the land through the Complete Systematic Land Registration Program (PTSL) at the Minahasa Regency Land Office, in carrying out their duties and functions on the number of employees where employees who run PTSL were the same employees in carrying out management work. with independent and cross-sector categories, so that it can be said to be included in the unfavorable criteria.

KINERJA APARATUR SIPIL NEGARA DALAM PENGURUSAN SERTIFIKAT TANAH MELALUI PROGRAM PENDAFTARAN TANAH SISTEMATIS LENGKAP (PTSL) DI KANTOR PERTANAHAN KABUPATEN MINAHASA

This study aims to determine and analyze the performance of state civil servants in obtaining land certificates through the Complete Systematic Land Registration Program (PTSL) at the Minahasa Regency Land Office. This research method uses a qualitative descriptive method, with research indicators consisting of quality, quantity, use of time and work commitment. Data analysis uses steps, namely data reduction, data presentation, levers or withdrawals, and data conclusions. The results showed that the performance of the state civil apparatus who took care of the land through the Complete Systematic Land Registration Program (PTSL) at the Minahasa Regency Land Office, in carrying out their duties and functions on the number of employees where employees who run PTSL were the same employees in carrying out management work. with independent and cross-sector categories, so that it can be said to be included in the unfavorable criteria.

Современные клинико-лабораторные особенности течения гриппа у взрослых

Обследованы и пролечены 472 больных гриппом, из них у 72 пациентов рентгенологически диагностирована пневмония, 69 из которых были госпитализированы в отделение реанимации и интенсивной терапии киевской городской клинической больницы № 4. Проведен анализ клинико-лабораторных данных больных гриппом, вызванным вирусом гриппа А (H1N1). Пневмония — одно из самых частых осложнений гриппа, которое существенно влияет на прогноз. Показано, что прогностически неблагоприятными критериями являются: позднее обращение за медицинской помощью (5–6-е сутки заболевания), развитие острого респираторного дистресс-синдрома, повышение или снижение лейкоцитов в крови и наличие тяжелой сопутствующей патологии.

Клініко-лабораторні особливості перебігу грипу у дорослих хворих в епідсезон 2015-2016 рр.

Поява в XXI столітті вірусних інфекцій респіраторного тракту, що набули ознак емерджентних (SARS, грип А (Н5N1, H1N1), MERS-CoV) обумовлюють достатньо високий показник смертності. Непередбачуваність еволюції вірусів грипу А викликає неспокій у спеціалістів всього світу. Мета. Провести порівняльний аналіз клініко-лабораторних особливостей при грипі А (H1N1) у дорослих з розвитком ускладнень, а також оцінка ефективності призначеної стартової терапії при пневмоніях. Матеріали і методи. Обстежено та проліковано 472 хворих на грип, з них у 72 пацієнтів рентгенологічно діагностовано пневмонію, 69 з яких були госпіталізовані у відділення реанімації та інтенсивної терапії КМКЛ № 4. Проведено аналіз клініко-лабораторної картини грипу у дорослих, спричиненого вірусом грипу А (H1N1). Результати і обговорення. Пневмонія – одне з найчастіших ускладнень грипу, що суттєво впливає на прогноз. Показано, що прогностично несприятливими критеріями є: пізнє звернення за медичною допомогою (5 – 6 доба захворювання), розвиток гострого респіраторного дистрес-синдрому (ГРДС), підвищення чи зниження лейкоцитів у крові та наявність тяжкої супутньої патології. Висновки. Результати аналізу супутньої патології різних систем та органів у хворих з грипом А (H1N1) показують, що захворювання серцево-судинної, ендокринної та системи крові є фактором ризику не лише тяжкого перебігу, але й летального наслідку захворювання в молодому віці. З лікарських засобів на прогноз та ступінь тяжкості перебігу суттєво впливає – раннє призначення етіотропної терапії, а призначення Нуклексу в рекомендованих дозах значно зменшує розвиток інших ускладнень та скорочує терміни перебування в стаціонарі.

Meningkatkan Motivasi Dan Hasil Belajar Siswa Dalam Pembelajaran Seni Tari Pada Masa Pandemi Covid-19 Di SMP N 4 Tarusan

This type of research is Class Action Research (PTK). This research will be carried out 2 cycles, cycle I is done 2 times and cycle II is done 2 times. The intrument used in this study are motivational questionnaires and student knowledge tests. This type of data uses primary data and secondary data. Data collection techniques are carried out by means of observation (observation), tests of learning outcomes (tests for work) and tests of student motivation in cultural arts (dance) subjects, then completed with documentation. Data is analyzed using the percentage formula. The results showed that the use of Demonstration Methods and lectures in the learning of cultural arts, especially dance arts in class VIII.3 junior high school N 4 Tarusan, South Coast can increase learning outcomes In addition to the use of Demonstration Methods, Lecture Methods and media can also avoid saturation in students in following the teaching and learning process, so as to foster student motivation, and more fun learning. This is evidenced by the existence of student learning outcomes in class VIII.3 in cycle I of the average student learning outcome of 61.61, with quite good criteria. Furthermore, student motivation towards cultural arts (dance) subjects averaged 53 with unfavorable criteria. In cycle II student learning outcomes increased by an average of 84.51% of excellent criteria. Furthermore, the motivation of students against dance arts subjects averaged 69.00 with quite good criteria. It can be concluded that the selection of strategies using the Demonstration Method, lecture method and media has succeeded in achieving the target above KKM which is 75.

METODE PENGADUAN FASILITAS PERKULIAHAN DAN PRAKTIKUM BERBASIS WEB (STUDI KASUS: STIKOM UYELINDO KUPANG)

The more rapid development of universities in Indonesia, the competition between universities is getting bigger so that the quality and facilities of each university greatly affect the attractiveness and competitiveness of universities. College of Computer Informatics Management (STIKOM) Uyelindo Kupang has 672 students. The campus of STIKOM Uyelindo Kupang has three departments, namely, first-class informatics engineering, undergraduate information systems and D3 informatics engineering with each accredited B. The development and improvement of lecture and practicum facility services at (STIKOM) Uyelindo Kupang is very important to be monitored and maintained. If the campus has provided services and facilities for students but these services and facilities are not monitored and maintained, sooner or later the services and facilities provided will be damaged and can no longer be used. The purpose of this research is to build a complaint information system website for lecture facilities and practicum to help and facilitate students. Based on the results of the test analysis using the Slovin method, there is an average value of 87% with Strongly Agree (SS) criteria. Even with the index value, when viewed based on the type of variable, there are several question items with unfavorable criteria. Question items with these criteria need to be considered for future website development. In the future, the website development will take into account the lowest index value of each indicator, especially those with poor and bad criteria.

FEATURES OF ARTERIAL HYPERTENSION COMBINED WITH OBESITY ACCORDING TO NON-ALCOHOLIC FATTY LIVER DISEASE (STEATOSIS AND STEATOHEPATITIS)

This research was aimed to estimate the course of hypertension on the background of obesity and nonalcoholic fatty liver disease according to its stages (steatosis and steatohepatitis). Ninety patients were evaluated for anthropometric, general-clinical, laboratory, instrumental and immune-enzymatic research methods. With USG, the most characteristic features of fatty liver infiltration and the criteria for the distinction of steatosis from steatohepatitis were revealed, and on the basis of them 2 groups were formed. Thus, the progression of nonalcoholic fatty liver disease to the stage of steatohepatitis was accompanied by a more pronounced increase in blood pressure larger in comparison with steatosis of mass index of myocardium and anterior-posterior size of the left atrium, indicating the progression of structural myocardial disorders. Therefore, the presence of non-alcoholic steatohepatitis in patients with hypertension can be regarded as unfavorable prognostic criteria for the development of heart failure. In the presence of steatohepatitis, more marked changes in lipidograms were noticed for Low-Density Lipoprotein and Triglyceride values and a violation of the functional state of the liver with a cytolytic syndrome on the activity of AST and ALT and the total bilirubin, which may contribute to the progression of liver damage.

Ураження суглобів при ANCA-асоційованих системних васкулітах Повідомлення І. Мікроскопічний поліангіїт

Артикулярний синдром є однією з основних ознак мікроскопічного поліангіїту (МПА), на частку якого в деяких регіонах земної кулі припадає понад 90 % усіх системних васкулітів (СВ), що пов’язані з антинейтрофільними цитоплазматичними антитілами (ANCA). Було встановлено, що за 5 років після дебюту МПА починають формуватися прогресуюче зменшення параартикулярної (епіфізарної) мінеральної щільності кістки й деструкція суглобів. Дуже багато питань, пов’язаних із характером перебігу суглобової патології при окремих ANCA-CB, вимагають подальшого вивчення. Мета: оцінити ураження суглобів у хворих на МПА та взаємозв’язки з екстраартикулярною патологією. Матеріал і методи. Під спостереженням перебували 89 хворих на МПА віком 18–78 років, серед яких було 44 % чоловіків і 56 % жінок. Тривалість хвороби від перших ознак її маніфестації становила 7 років. Гострий або підгострий перебіг МПА встановлено в 27 % випадків, у решти — хронічний; І ступінь активності патологічного процесу констатовано в 10 % спостережень, ІІ — в 32 %, ІІІ — в 58 %. Результати. Ураження суглобів спостерігається в 60 % від числа хворих на МПА, що у 40 % випадків перебігає у вигляді олігоартриту, залежить від наявності патології скелетних м’язів, пневмопатії і периферійної нейропатії. Клінічні, рентгенологічні та сонографічні ознаки артикулярної патології при МПА значно пов’язані з віком пацієнтів, тривалістю захворювання, ураженням серця, нирок і шкіри. У патогенетичних побудовах артропатії у хворих на МПА беруть участь С-реактивний протеїн (CRP) та циркулюючі імунні комплекси (CIC), а слабке значення має характер ANCA (антитіла до мієлопероксидази і протеїнази-3), при цьому певну прогнознегативну значущість щодо тяжкості суглобової патології мають високі параметри в крові ревматоїдного фактора (RF). Висновок. Прогнознегативними критеріями щодо розвитку патології суглобів у хворих на МПА є показники в крові: CRP > 20 мг/л і CIC > 130 ум.од., а значення RF > 60 МО/мл вважаються чинниками ризику тяжкого перебігу артропатії.

Ураження суглобів при ANCA-асоційованих системних васкулітах. Повідомлення ІІ. Гранулематозні поліангіїти Вегенера та Черджа-Стросса

Як єдиний варіант некротизуючого гранулематозного системного васкуліту (CB), пов’язаного з антинейтрофільними цитоплазматичними антитілами (ANCA), розглядаються васкуліти Вегенера (гранулематоз із поліангіїтом — ГПА) та Черджа-Стросса (еозинофільний поліангіїт — ЕПА). Існує нагальна потреба подальшого вивчення суглобового синдрому у хворих на ANCA-CB. Мета: оцінити частоту й характер ураження суглобів при ГПА та ЕПА, взаємозв’язок з екстраартикулярними ознаками захворювань. Матеріал і методи. Під наглядом перебували 58 хворих на ANCA-СВ, серед яких було 28 пацієнтів із ГПА (16 чоловіків і 12 жінок віком від 17 до 70 років) та 30 — з ЕПА (14 чоловіків і 16 жінок віком від 19 до 70 років). Середня тривалість хвороби в першій та другій групах відповідно становила 4 й 11 років. Співвідношення I, II і III ступенів активності ГПА було 1 : 6 : 7, а у випадках ЕПА — 1 : 3 : 4. Якщо патологію легенів діагностовано в усіх спостереженнях ЕПА, то у хворих на ГПА — в 68 % випадків. Окрім того, в 2,3 раза рідше виявляли шкірний синдром. Результати. Ураження суглобів у вигляді артриту або артралгій спостерігається в 1/2 від числа хворих на гранулематозні ANCA-CB у співвідношенні ГПА до ЕПА як 1 : 2, що пов’язане зі ступенем тяжкості екстраартикулярних проявів захворювань, а у випадках ЕПА — і з рівнем антитіл до протеїнази-3. У хворих на ЕПА вірогідно частіше діагностували ураження верхньощелепних зчленувань, міжфалангових суглобів, гомілковостопних, плеснофалангових, кульшових, крижово-клубових та хребцевих, причому останні 4 у хворих на ГПА взагалі не відмічалися. Епіфізарний остеопороз, субхондральний склероз, остеокістоз, артрокальцинати й зміни рогів менісків колінних суглобів спостерігали виключно при ЕПА. Висновки. Вираженість артропатії при ЕПА порівняно з ГПА переважає, перебігає з більшими запально-дегенеративними змінами суглобового апарату, хоча інтраартикулярні тіла Гоффа властиві тільки пацієнтам із ГПА. Прогнознегативними критеріями щодо суглобової патології при ГПА є високі показники в крові імуноглобуліну M та циркулюючих імунних комплексів, а при ЕПА — фібриногену.

Perioperative Perfusion of Allografts with Anti-Human T-lymphocyte Globulin Does Not Improve Outcome Post Liver Transplantation-A Randomized Placebo-Controlled Trial.

Due to the lack of suitable organs transplant surgeons have to accept unfavorable extended criteria donor (ECD) organs. Recently, we demonstrated that the perfusion of kidney organs with anti-human T-lymphocyte globulin (ATLG) prior to transplantation ameliorates ischemia-reperfusion injury (IRI). Here, we report on the results of perioperative ATLG perfusion in a randomized, single-blinded, placebo-controlled, feasibility trial (RCT) involving 30 liver recipients (LTx). Organs were randomly assigned for perfusion with ATLG/Grafalon® (AP) (n = 16) or saline only (control perfusion = CP) (n = 14) prior to implantation. The primary endpoint was defined as graft function reflected by aspartate transaminase (AST) values at day 7 post-transplantation (post-tx). With respect to the primary endpoint, no significant differences in AST levels were shown in the intervention group at day 7 (AP: 53.0 ± 21.3 mg/dL, CP: 59.7 ± 59.2 mg/dL, p = 0.686). Similarly, exploratory analysis of secondary clinical outcomes (e.g., patient survival) and treatment-specific adverse events revealed no differences between the study groups. Among liver transplant recipients, pre-operative organ perfusion with ATLG did not improve short-term outcomes, compared to those who received placebo perfusion. However, ATLG perfusion of liver grafts was proven to be a safe procedure without the occurrence of relevant adverse events.

Environmental geology assessment on the regional Pitay landfill site: a case study in Kupang, Indonesia

The Provincial Government of East Nusa Tenggara of Eastern Indonesia has intended to construct a new regional landfill site in Pitay–Kupang, which would accommodate municipal waste of two cities. Considering that environmental degradation in landfill sites has been a substantial issue for many developing cities in Indonesia, this study evaluates the pre-determined site on a local scale based on environmental geology parameters. It employs a conventional Geographical Information System based—Multi-Criteria Decision Analysis (GIS-MCDA) method which is based on the analysis of regional criterion, assessed by expressing values on each parameter presented on thematic maps and overlaid altogether as a screening process, and the exclusion criterion analysis, which sets a buffer zone to filter out irrelevant locations. The regional criterion parameters are: Lithology, groundwater depth, slope gradient and rainfall intensity, whilst the exclusion criterion parameters are: Distance from rivers and lakes, shorelines, settlements, main roads, airports and protected areas, distance from potential geological hazards such as fault zones, floods and mass movements, and distance from any geological potential which may be developed in the future. The biggest area reduction for suitable landfill site candidate is lithology, correlating with groundwater depths, and distance from rivers. Here we identified four potential sites located west and centre of Pitay, situated on Bobonaro scaly clay lithology unit, arguably possessing no groundwater with a slope gradient of 0–20%, rainfall intensity below 1000 mm, and is distant from any potential hazards, promising geological resources and other unfavorable criteria relating to environmental degradation.

Feasibility and Assessment of a Machine Learning-Based Predictive Model of Outcome After Lumbar Decompression Surgery.

Study design:Retrospective study at a unique center.Objective:The aim of this study is twofold, to develop a virtual patients model for lumbar decompression surgery and to evaluate the precision of an artificial neural network (ANN) model designed to accurately predict the clinical outcomes of lumbar decompression surgery.Methods:We performed a retrospective study of complete Electronic Health Records (EHR) to identify potential unfavorable criteria for spine surgery (predictors). A cohort of synthetics EHR was created to classify patients by surgical success (green zone) or partial failure (orange zone) using an Artificial Neural Network which screens all the available predictors.Results:In the actual cohort, we included 60 patients, with complete EHR allowing efficient analysis, 26 patients were in the orange zone (43.4%) and 34 were in the green zone (56.6%). The average positive criteria amount for actual patients was 8.62 for the green zone (SD+/- 3.09) and 10.92 for the orange zone (SD 3.38). The classifier (a neural network) was trained using 10,000 virtual patients and 2000 virtual patients were used for test purposes. The 12,000 virtual patients were generated from the 60 EHR, of which half were in the green zone and half in the orange zone. The model showed an accuracy of 72% and a ROC score of 0.78. The sensitivity was 0.885 and the specificity 0.59.Conclusion:Our method can be used to predict a favorable patient to have lumbar decompression surgery. However, there is still a need to further develop its ability to analyze patients in the “failure of treatment” zone to offer precise management of patient health before spinal surgery.

Use of extracorporeal membrane oxygenation for eCPR in the emergency room in patients with refractory out-of-hospital cardiac arrest.

Out-of-hospital cardiac arrest (OHCA) refractory to conventional high-quality cardiopulmonary resuscitation (CPR) may be rescued by extracorporeal CPR (eCPR) using veno-arterial extracorporeal membrane oxygenation (V-A ECMO). Even when trying to identify eCPR candidates based on criteria assumed to be associated with a favourable neurological outcome, reported survival rates are frequently below 10%. All patients undergoing implantation of V-A ECMO for eCPR between January 2018 and December 2019 (N = 40) were analysed (age 53±13 years; 75% male). Patients with refractory OHCA and potentially favourable circumstances (initial shockable rhythm, witnessed arrest, bystander CPR, absence of limiting comorbidities, age <75 years) were transported under mechanical chest compression. Candidates for eCPR should have a pH ≥6.9, arterial lactate ≤15 mmol/L and time-to-ECMO should be ≤60 minutes. Overall 30-day survival was 12.5%, with 3 of 5 survivors having a favourable neurological outcome (cerebral performance category (CPC) 1 or 2), representing 7.5% of the total eCPR population. No patient selected for eCPR met all pre-defined criteria (median of unfavourable criteria: 3). Importantly, time-to-ECMO most often (39/40) exceeded 60 minutes (mean 102 ±32 min.), and lactate was >15mmol/L in 30 out of 40 patients. Moreover, 22 out of 40 patients had a non-shockable rhythm on the first ECG. Despite our intention to select patients with potentially advantageous circumstances to achieve acceptable eCPR outcomes, the imminent deadly consequence of withholding eCPR obviously prompted individual physicians to perform the procedure also in presumably more unfavourable settings, resulting in similar mortality rates of eCPR as reported before.

Long-term outcomes of patients with unfavorable stage I–II classic Hodgkin lymphoma treated with Stanford V chemotherapy and limited field irradiation

Management of stage I–II unfavorable risk Hodgkin lymphoma (HL) strives to reduce toxicity while maintaining tumor control. Compared to ABVD or BEACOPP, Stanford V chemotherapy contains less doxorubicin and bleomycin. We report long-term outcomes of patients with stage I–II classic HL with European risk factors treated with Stanford V combined modality therapy (CMT). From our institutional cancer registry, we identified 168 patients with ≥1 European risk factor treated with 8–12 weeks of Stanford V CMT and consolidative radiotherapy between 1990 and 2016. Outcomes were analyzed after classification by EORTC and GHSG unfavorable criteria. With median follow-up of 8.4 years, 10-year overall survival and progression-free survival for the entire cohort were 95% and 88%, respectively. Thirteen of 18 relapses were salvaged successfully. There were no cases of MDS or AML after primary therapy. Long-term outcomes of stage I–II unfavorable risk HL treated with Stanford V CMT are comparable to ABVD or BEACOPP regimens.

Survival and prognostic tests in a real-world phase II experience with a safe, moderate-dose, sequential chemotherapy (CT) algorithm (ALGO) for metastatic pancreatic adenocarcinoma (PANC).

e16763 Background: Gemcitabine (G), 5-fluorouracil (F), leucovorin (L), irinotecan (I), and oxaliplatin (O), (GFLIO) is safe, employs moderate 1/2-1/3 dosages, offers expanded eligibility (0-2 ECOG PS; no age limit)). Each step reverse resistance (RR) to CT; drug synergism 4-6 simultaneous pairs) improve responses (Rs) and survival (S) (Bruckner ASCO 05, 08, 11, AntiCancer Res 2016; 36 (1), 2018; 38 (1) (ACR), and the immune system (Correale P: J. Immunother 2014; 37). M Caraglia: Front Oncol. 2019). Methods: Eligibility: intent to treat active metastatic PANC, no prior CT: any age: PS 0-2 and expected &gt; 6 weeks S. IRB required safety &lt; 1/10 severe events. ALGO in mg/m2: G 500, F 12-1500 over 24 hrs, L 180, I 80, day2 O (GFLIO) q2 wks, and on progression added in sequence, day 2, docetaxel 20-25 and good counts only mitomycin C 3-6 then bevacizumab 10mg/kg with prior monitoring and modifications (ACR). Median 12, 18, 24 mos Overall Survival (OS), Kaplan Meier estimates with 95% CI were evaluated with age, sex and normal nl and abnl baseline bloods: neutrophils N ANC; Lymphs Ly ALC; platelets; albumin (ALB); Alkaline phosphatase (Alk Ph) abn N alb 3.5 N/L; 2.1 L/monocyte ratios and the A.L.A.N (AS) composite prognostic score (M. Salati E.J.Ca. 2019; 117: 84-90). Results: OS @ 6, 12, 18 &amp; 24 mos, for 53 pts, was 75; 57; 36; 26 % (+/- 8-10%). Median M S was 14.5 mo (CI 9-17mos); S @ all ages ≥ 60, 65 or 70, was not inferior. Women's M S 17 mo. was &gt; men's 10.5: 95/65; 75/46; 48/29; 42/29%. AS for abnl tests was: 0 (18pts): 93: 81: 48; 34% &amp; MS 17 mo vs 1-2 (23)90: 58;42;32% &amp; MS 15.5mo vs 3-4 (12)MS 3 mo. Pts with best 17-14.5 mo MS had nl AS 0 &gt; Alb &gt; AS 1-2 &gt; APh &gt; ANC. Pts with worst 3-6 mo MS had abnl: AS 3-4 &lt; Alb &lt; ANC. No pt had severe infection, neuropathy or gastroenteritis. Pts -/+ 75-100gm ascorbic acid, 25, did not have inferior S in ALAN subsets (H.Bruckner AACR 17). Conclusions: The sequential moderate dose CT ALGO improves eligbility and provides pts with metastatic PANC of any age a well tolerated CT regimen with a high therapeutic index and strong, 12, 18, 24 mo, survival. Prognostic tests can identify subgroups ≥ 75% with favorable vs. unfavorable criteria and improve personalized choices and measures to remedy individual risk factors. Clinical trial information: NCT01905150 .

PENGARUH AKUNTANSI ZAKAT TERHADAP AKUNTABILITAS PUBLIK BADAN AMIL ZAKAT NASIONAL (BAZNAS) DAN LEMBAGA AMIL ZAKAT (LAZ) KABUPATEN/KOTA DI PROVINSI SUMATERA SELATAN

The purpose of this study was to determine the effect of zakat accounting on public accountability of BAZNAS and LAZ in South Sumatra Province with the methodology used was descriptive using a questionnaire. While the data analysis used is simple linear regression analysis. So from this study it can be seen that the accounting for zakat influences the accountability of BAZNAS and LAZ in South Sumatra Province by 73.9%, then based on the results of the study it is known that the tendency of zakat accounting carried out by zakat institutions in South Sumatra Province has unfavorable criteria of 3 institutions or 10%, 2 institutions are quite good criteria, 5 institutions with good criteria and with very good criteria are 66.6% or as many as 20 amil zakat institutions.