In the Hong Kong–Zhuhai–Macau Bridge mega project, several ground treatment methods were applied in the transition area between the artificial island and immersed tube tunnels to reduce the potential uneven foundation settlement underlying the tunnel, as the backfilled sand layer is more than 10 m around it. One of the foundation improvement methods involves the combination of preload and high-pressure jet grouting (HPJG) columns. Current field tests, such as core bowling, standard penetration test, and plate loading test, are not suitable for evaluating the strength of this reinforced foundation. This study presents a full-scale load test to examine the construction quality and effects of an HPJG-reinforced foundation. A novel method was designed based on the Boussinesq equation to simulate the additional stress distribution from the immersed tube tunnel. The tangent modulus method considering the impact of modulus nonlinearity was employed to calculate the nonlinear settlement of the treated foundation. Preferable settlement results were obtained using a set of pre-embedded high-precision hydrostatic leveling systems. Both the measured data and calculated settlement demonstrate the reasonableness of the present in situ test.