Since ineffective FL vocabulary teaching has been currently shown in the higher education of Mainland China, this study aims to achieve a satisfactory vocabulary teaching outcome through the construction of a systematic computer-based vocabulary teaching mode. Based on constructivism, the mode was established with three essential teaching phases, which were incorporated with systematic cognitive processes of vocabulary learning, supported by appropriate vocabulary teaching strategies, and also facilitated by computer technologies. To illustrate its efficacy, altogether 58 non-English major undergraduate students in two classes were selected randomly from a university in Mainland China. The participants were divided into two groups by class, which were taught target words under the computer-based systematic vocabulary teaching mode and the traditional paper-based one, respectively. Under the traditional mode, the same teacher adopted the teaching methods as they had normally done in the past, such as rote memorization and mechanical practice mainly with paper-based materials. Through the achievement comparisons, it was ultimately revealed that the systematic computer-based vocabulary teaching mode was superior to the traditional with a detectable difference either immediately after or one month after the treatment. The significance was further reinforced by the results from a questionnaire survey conducted among the group taught under the systematic computer-based vocabulary teaching mode.