Regional culture is a comprehensive embodiment of the geographical environment, living forms, historical inheritance, and humanistic spirit of a region, and is a valuable resource for the region’s sustainable development. The current regional culture-related curriculum of art and design courses in many local colleges and universities is monotonous, and the concept of talent training is outdated. Thus, it is time to carry out a reform of this curriculum based on the regional culture characteristics. Using a normal university in Henan Province as an example, this paper discusses how to effectively integrate the regional culture into the curriculum model reform. Data were collected from 533 undergraduate design students and used to examine the following issues: (i) Analysing the integration of the art and design curriculum with the regional culture, (ii) Proposing a comprehensive teaching model for the integrated art and design curriculum.