There is limited data on the sex differences in in-hospital outcomes of patients undergoing ventricular tachycardia (VT) ablation. We aimedto utilize a nationwide cohort to determine the sex differences in in-hospital outcomes of patients undergoing VT ablation in the United States. We utilized the Nationwide Inpatient Sample (NIS) from 2016-2019 to identify the patients undergoing VT ablation. Primary outcome was in-hospital mortality. Secondary outcomes included cardiogenic shock, acute kidney injury (AKI), new requirement of dialysis, cardiac tamponade, blood transfusion, and vascular complications. Multivariate logistic regression was used to adjust for baseline characteristics. There were a total of 34,425 hospitalizations for VT ablation during 2016-2019, of which 8,262 (24%) were in female patients. Females undergoing VT ablation were younger and had significantly fewer comorbidities including congestive heart failure, peripheral vascular disease, coronary artery disease, chronic obstructive pulmonary disease, diabetes, and coagulopathy. After adjustment for baseline characteristics, there were no significant differences between females and males in adjusted in-hospital mortality [aOR: 1.03 (0.72-1.46), p=0.86], cardiac tamponade and blood transfusion. Females had significantly lower odds of developing AKI, however they were more likely to have vascular complications. Females represent one-fifth of patients undergoing VT ablation in the United States, and are younger and with fewer comorbidities compared to males. Although vascular complications were more common in females and AKI more frequent in males, no significant sex differences in other major peri-procedural complications and in-hospital mortality were found.
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