The article is grounded a design concept, a research process of constituents of forming of culturological competence of future nurses in the process of professional preparation, using a design method. It has been identified the main processes of forming of culturological competence of future nurses as a difficult multicomponent category, which all constituents are interdependent and reciprocal, and direct to organization of the process of forming of culturological competence of future nurses in the process of professional preparation on the basis of theoretical analysis and synthesis of the concepts such as “a design” and “a model”.It is marked, that the aim of forming of culturological competence of future nurses forms the nurse’s personal culture, able to represent a high level of formed personality, professionally-medical culture, that is based on mastering of mental and ethical, communicative knowledge, abilities and skills, and also improvment and development of professionally important personality internals.The successful and effective process of forming of culturological competence for its organization needs some of terms: plugging of future nurses in active creative activity, that stimulates cognitive interest in understanding of conformity to the aim of culture development as a process of creation, maintenance and translation of common to all mankind values; feeling of a person not only an object but also a subject of cultural and historical process; an orientation is in traditions, realities, customs, spiritual values of not only the community but also other nations; an ability expediently and effectively to come forward, to communicate in the modern world, operating by cultural concepts and offenses of different people.During process of the of culturological competence forming of future nurses in the process of professional preparation we leaned against the traditional pedagogical principles of humanism and democracy, scientific character, unity of theory and practice, logical sequence of material presentation, professional orientation.Traditional and unconventional methods, forms of studies are marked in this work. Among unconventional forms to realization of educational activity are used business games, disputes, problem situations, Delta plus, Case method.