The construction industry is complex, and its success depends on time, cost, and project quality. The study sought to investigate construction project success in relation to time, cost, quality, and safety on construction projects in the Ashanti Regions of Ghana. A structured questionnaire was administered among construction professionals (architects, contractors, engineers, and quantity surveyors) within the study area. The findings showed delays in payments of works executed, forceful layoff, and suspension of construction works adversely affected construction time. The construction project cost was attributed to delays in payment to contractors, poor client cash flow, and high cost of plant and equipment. Quality of work was ascribed to poor coordination among workers and frequent absenteeism of skilled workers. It was concluded that governments should provide financial support to construction companies to clear backlogs of unpaid debts to workers. Clients should liaise with contractors to reschedule uncompleted projects (payment plans and added time for the completion of works). Construction companies should provide adequate personal protective equipment (PPE) to minimise on-site health-related hazards.