Low-cost particulate matter sensors (LCS) are vital for improving the spatial and temporal resolution of air quality data, supplementing sparsely placed official monitoring stations. Despite their benefits, LCS readings can be biased due to the physical properties of aerosol particles and device limitations. An optimization model is essential to enhance LCS data accuracy. This paper presents a calibration study of the LCS network of Timișoara, Romania. The calibration began by selecting LCS devices near National Air Quality Monitoring Network (NAQMN) stations and developing parametric models, choosing the best for broader application. Plantower, Sensirion, and Honeywell sensors showed comparable accuracy. Calibration involved clusters within a 750 m radius around NAQMN stations. Models incorporating RH corrections and multiple linear regression (MLR) were fitted. The best model was validated against data from unseen sensors, leading to mean bias errors (MBE) within 9-17% and RMSEs of 33-35%, within sensor uncertainty margins. Applied to the city-wide LCS network, the model identified several stations regularly exceeding the EU daily PM10 threshold, unnoticed by NAQMN stations due to their limited coverage. The study highlights the necessity of granular monitoring to accurately capture urban air quality variations.