Uncaria Gambier Roxb Research Articles

UJI EFEKTIVITAS ANTIMIKROBA PADA EKSTRAK DAUN GAMBIR (UNCARIA GAMBIER ROXB.) DAN DAUN SIRIH HIJAU (PIPER BETLE LINN.) TERHADAP STREPTOCOCCUS MUTANS, ESCHERICHIA COLI DAN CANDIDA ALBICANS

Gambier contains two main components, namelycatechin and katekutanat acid. According to Lemmens (1999), gambier have three benefits: fortanning leather; as a stimulant as well as medicine. This study aims to determine the concentrationof the inhibition gambier (Uncaria gambier Roxb.) and betelleaf (Piper betle Linn.) as well astocompare the differences in the inhibition of growth of Streptococcusmutans, Escherichiacoli and Yeast Candida albicans. The Results showed that gambier extract (Uncaria gambier Roxb.) and green betelleaf (Piper betle Linn.) indicates that the leaf extract of betelleaf and gambier have no activity on hibiting the growth of Candida albicans. However extract from betelleaf can inhibit the growth of Streptococcus mutans and Escherichia coli with a minimum concentration levels of 25%.

Inhibitory concentration and minimum contact time of Gambier extract (Uncaria gambier Roxb) to growth of Enterococcus faecalis

Inhibitory concentration and minimum contact time of Gambier extract (Uncaria gambier Roxb) to growth of Enterococcus faecalis

Uji Aktivitas Antijamur Ekstrak Gambir (UncariagambirRoxb) terhadap Candida albicans secara in Vitro

Effective treatment is being sought for the discovery of antifungal compounds.One of Plants that are suspected as a potential antifungal is Gambir (Uncaria gambierRoxb.). Gambir contains high antioxidants. Gambier containing catechin, katekutannat, quercetin, gallic acid, and catechol elagat acid, has been studied to determine its antifungal activity. This study was done by using experimental in vitro tube dilution method. The general objective of this study was to investigate the inhibition of ethanolic extract and water extract of gambier towards the growth of Candida albicans. Specific objectives were to determine Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC)of ethanolic extract and water extract of gambier towards the growth of Candida albicans. The concentration used were 50% , 60% , 70% , 80% , 90% and 100% . The results showed thatMICof the ethanolic extract of gambier could not be determined, while the MBCwas 100%. One Way ANOVA statistical analysis results showed p= 0.004 ( p< 0.05 ), indicating significant differences in changes of the concentration of ethanol extract gambier to the number of colonies ofCandida albicans. Correlation test showed a close relationship between the concentration of gambier extract and the number of colonies ( r = -9.900 : p < 0.05 ). Regression test yielda linear regression equation Y = 5,034-0,048x with R Square coefficient ( r2 ) of 0.802. Based on the research results it can be concluded that the ethanolic extract of gambier has antifungal effect against Candida albicans.

ASSESSMENT OF COMMODITIES AREA GAMBIER (Uncaria gambir Roxb.) IN PAKPAK BHARAT SCALE 1 : 50.000

Gambier (Uncaria gambier Roxb.) is a cultivated plant regeneration in Pakpak Bharat. Gambir extract benefits as well as the pharmaceutical industry and traditional is quite interested so that market opportunities gambier quite open for the domestic market and abroad. Land potential and development opportunities gambir high enough, it is in the use of plantation area of 1,224 ha and optimization of dry land area of 16 049, 6 hectares (Pakpak Bharat in Figures, 2013). Gambier development in Pakpak Bharat tends to increase, so it is necessary to study the suitability of land to see the direction of the development of the appropriate location. This assessment was conducted by using ALES (Automated Land Evaluation System). SDPLE (Standard Procedure for Land Evaluation) data was imported to ALES program. Land evaluation result was show in spatial form. This form made by imported tabulation data to GIS (Geographical Information System) form. Suitability land maps (scale 1 : 250.000) present based on each commodities by ArcView program.

Gambier extracts as an inhibitor of calcium carbonate (CaCO 3) scale formation

The investigation of Gambier extracts ( Uncaria gambier Roxb leaves) as an inhibitor of calcium carbonate scale formation has been carried out using the bottle-roller batch method with the concentration of a growth solution ranging from 0.1 to 0.6 M and at the temperature of 80 °C. The data obtained shows that Gambier extracts inhibit the formation of calcium carbonate scale at the various concentrations of the growth solution. The ability of Gambier extracts as an inhibitor of the formation of calcium carbonate scale is around 40–100% in inhibiting the growth rate of CaCO 3 scale. This ability depends on the concentration of Gambier extracts added into the growth solution and the concentration of the growth solution as a growth media of CaCO 3 seed crystals.

Effect of gambir extract Uncaria gambierRoxb. on fetal of pregnant mice induced by alcohol

Anomaly in the fetus of mice may induced by the present of oxidative stress on the dam during gestation. Alcohol is a potential substance that able to generate the oxidative stress. Antioxidant theoretically should reduce the above process. Gambir extract is a notorious non toxic herbal which rich of antioxidants. This study aims to see whether the oxidative stress in pregnant mice induced by alcohol could be suppressed with gambir extracts. The results showed that administration of gambir extract to thepregnant dam of mice after been induced by alcohol during gestation, reduced the presence of a thrombus on the pup. Key words: Gambir extract, ethanol, teratogen, mice

7α-Acetoxydihydronomilin: isolation, spectra, and crystal structure

Methanol extraction of the ground seeds of Uncaria Gambier Roxb. followed by chromatography afforded a crystalline C30H38O10 terpene. This has been shown by X-ray analysis to be 7α-acetoxydihydronomilin. The crystals are orthorhombic, P212121, a = 13.158(2), b = 17.092(2), c = 12.689(2) Å, Z = 4, dx = 1.300, do = 1.300 g cm−3. The structure has been determined by the direct method and Fourier syntheses, and refined by block-diagonal least-squares to R = 0.042 for 2621 observed reflexions. The molecule contains a seven-membered lactone ring A, three six-membered rings B, C, D, a three-membered ring E, a furan ring F, and two acetate groups. A and B are chair, C is twist-boat, D is 1,3-diplanar, while E and F are planar. The A/B, A/C, C/D junctions are trans, D/E is cis, and F is linked to D by an equatorial C—C bond. The two acetate groups are in axial positions on A and B and are cis to each other. The O atom forming the apex of the three-membered ring is wedged between two H atoms and their parent C atoms at short intramolecular distances O … H = 2.28(2) and 2.28(3), and O … C = 2.623(3) and 2.668(4) Å. No intermolecular hydrogen bonding is indicated.