UV Sensitivity Research Articles

OSpRad: an open-source, low-cost, high-sensitivity spectroradiometer.

Spectroradiometry is a vital tool in a wide range of biological, physical, astronomical and medical fields, yet its cost and accessibility are frequent barriers to use. Research into the effects of artificial light at night (ALAN) further compounds these difficulties with requirements for sensitivity to extremely low light levels across the ultraviolet to human-visible spectrum. Here, I present an open-source spectroradiometry (OSpRad) system that meets these design challenges. The system utilises an affordable miniature spectrometer chip (Hamamatsu C12880MA), combined with an automated shutter and cosine-corrector, microprocessor controller, and graphical user interface 'app' that can be used with smartphones or desktop computers. The system has high ultraviolet sensitivity and can measure spectral radiance at 0.001 cd m-2 and irradiance at 0.005lx, covering the vast majority of real-world night-time light levels. The OSpRad system's low cost and high sensitivity make it well suited to a range of spectrometry and ALAN research.

Rpb7 represses transcription-coupled nucleotide excision repair

Transcription-coupled repair (TCR) is a subpathway of nucleotide excision repair (NER) that is regulated by multiple facilitators, such as Rad26, and repressors, such as Rpb4 and Spt4/Spt5. How these factors interplay with each other and with core RNA polymerase II (RNAPII) remains largely unknown. In this study, we identified Rpb7, an essential RNAPII subunit, as another TCR repressor and characterized its repression of TCR in the AGP2, RPB2, and YEF3 genes, which are transcribed at low, moderate, and high rates, respectively. The Rpb7 region that interacts with the KOW3 domain of Spt5 represses TCR largely through the same common mechanism as Spt4/Spt5, as mutations in this region mildly enhance the derepression of TCR by spt4Δ only in the YEF3 gene but not in the AGP2 or RPB2 gene. The Rpb7 regions that interact with Rpb4 and/or the core RNAPII repress TCR largely independently of Spt4/Spt5, as mutations in these regions synergistically enhance the derepression of TCR by spt4Δ in all the genes analyzed. The Rpb7 regions that interact with Rpb4 and/or the core RNAPII may also play positive roles in other (non-NER) DNA damage repair and/or tolerance mechanisms, as mutations in these regions can cause UV sensitivity that cannot be attributed to derepression of TCR. Our study reveals a novel function of Rpb7 in TCR regulation and suggests that this RNAPII subunit may have broader roles in DNA damage response beyond its known function in transcription.

Dose-Response Behavior of Pathogens and Surrogate Microorganisms across the Ultraviolet-C Spectrum: Inactivation Efficiencies, Action Spectra, and Mechanisms.

The dose-response behavior of pathogens and inactivation mechanisms by UV-LEDs and excimer lamps remains unclear. This study used low-pressure (LP) UV lamps, UV-LEDs with different peak wavelengths, and a 222 nm krypton chlorine (KrCl) excimer lamp to inactivate six microorganisms and to investigate their UV sensitivities and electrical energy efficiencies. The 265 nm UV-LED had the highest inactivation rates (0.47-0.61 cm2/mJ) for all tested bacteria. The bacterial sensitivity strongly fitted the absorption curve of nucleic acids at wavelengths of 200-300 nm; however, indirect damage induced by reactive oxygen species (ROS) was the leading cause of bacterial inactivation under 222 nm UV irradiation. In addition, the guanine and cytosine (GC) content and cell wall constituents of bacteria affect inactivation efficiency. The inactivation rate constant of Phi6 (0.13 ± 0.002 cm2/mJ) at 222 nm due to lipid envelope damage was significantly higher than other UVC (0.006-0.035 cm2/mJ). To achieve 2log reduction, the LP UV lamp had the best electrical energy efficiency (required less energy, average 0.02 kWh/m3) followed by 222 nm KrCl excimer lamp (0.14 kWh/m3) and 285 nm UV-LED (0.49 kWh/m3).

Artificial Leaky Integrate-and-Fire Sensory Neuron for In-Sensor Computing Neuromorphic Perception at the Edge.

Neuromorphic perception and computing show great promise in terms of energy efficiency and data bandwidth compared to von Neumann's computing architecture. In-sensor computing allows perception information processing at the edge, which is highly dependent on the functional fusion of receptors and neurons. Here, a leaky integrate-and-fire (LIF) artificial spiking sensory neuron (ASSN) based on a NbOx memristor and an a-IGZO thin-film transistor (TFT) is successfully developed. The ASSN is fabricated mainly through simple sputter deposition processes, showing the prospect of high process compatibility and potential for integration fabrication. The device shows excellent spike encoding ability to deliver the neuromorphic information through spike rate and time-to-first spike. Moreover, in the ASSN, the a-IGZO TFT not only provides the fundamental spike signal computing function of the artificial neuron but also has NO2 gas and ultraviolet (UV) light dual sensitivity to introduce the neuromorphic perception capability. As a result, the ASSN successfully exhibits an inhibitory property under NO2 stimulation while exhibiting an excitatory state under UV light stimulation. Futhermore, self-adaption and lateral regulation circuits between different ASSNs are proposed at the edge in mimicking biological neurons' rich interconnection and feedback mechanisms. The ASSNs successfully achieve self-regulation after a huge response during a burst stimulus. In addition, the neuron transmits a more obvious output when the target-sensitive events occur through the edge internal regulation. The self-adaption and lateral regulation demonstrated in ASSN move an important step forward to in-sensor computing, which provides the potential for a multiscene perception in complex environments.

Current Understanding of the Effects of Sun Exposure on Skin Tanning: Mechanisms, Risks, and Protective Strategies

UV radiation (UV) is designated as a "comprehensive carcinogen" due to its dual nature as a mutagen and a non-specific damaging agent, exhibiting properties of both a tumor initiator and a tumor promoter. UV radiation is the foremost modifiable risk factor for skin cancer and various other environmentally-influenced skin disorders. Nevertheless, UV radiation also plays a beneficial role in human health by facilitating the natural synthesis of vitamin D and endorphins in the skin. Consequently, UV radiation exhibits complex and diverse effects on human health. However, excessive exposure to UV radiation poses significant health risks, including skin atrophy, pigmentary alterations, wrinkling, and malignancy. Epidemiological and molecular evidence establish a clear link between UV radiation and the three most prevalent types of skin cancer: basal cell carcinoma, squamous cell carcinoma, and malignant melanoma, collectively impacting over a million Americans each year. Furthermore, genetic factors contribute to the susceptibility of UV-mediated skin diseases. Notably, specific variations in the melanocortin 1 receptor (MC1R) gene are associated with skin fairness, UV sensitivity, and heightened cancer risk. In light of these findings, our research aims to develop innovative UV-protective strategies by comprehensively understanding the molecular events that occur following UV exposure, with a specific focus on epidermal melanization and the pivotal role played by the MC1R in maintaining the integrity of the genome. By leveraging this knowledge, we endeavor to devise pharmaceutical interventions that can effectively mitigate the detrimental effects of UV radiation on the skin, reduce the risk of skin cancer, and enhance skin health. Such advancements will not only contribute to safeguarding individuals from the harmful consequences of excessive UV exposure but also pave the way for novel approaches in the field of dermatology and personalized medicine, tailored to the individual's genetic makeup and specific risk factors.

Encapsulation of Ammoides pusila Essential Oil into Mesoporous Silica Particles for the Enhancement of Their Activity against Fusarium avenaceum and Its Enniatins Production

Essential oils (EOs) that have antifungal activity and mycotoxin reduction ability are candidates to develop bioactive alternatives and environmentally friendly treatment against Fusarium species in cereals. However, their practical use is facing limitations such as high volatility, UV sensitivity, and fast oxidation. Encapsulation techniques are supposed to provide protection to the EOs and control their release into the environment. Ammoides pusilla essential oil (AP-EO) proved to be an efficient inhibitor of Fusarium avenaceum growth and its enniatins (ENNs) production. In the present work, AP-EO was encapsulated, using the impregnation method, into mesoporous silica particles (MSPs) with narrow slit pores (average diameter = 3.1 nm) and coated with chitosan. In contact assays using an agar medium, the antifungal activity of AP-EO at 0.1 µL mL-1 improved by three times when encapsulated into MSPs without chitosan and the ENNs production was significantly inhibited both in coated and non-coated MSPs. Controls of MSPs also inhibited the ENNs production without affecting the mycelial growth. In fumigation experiments assessing the activity of the EO volatile compounds, encapsulation into MSPs improved significantly both the antifungal activity and ENNs inhibition. Moreover, coating with chitosan stopped the release of EO. Thus, encapsulation of an EO into MSPs improving its antifungal and antimycotoxin properties is a promising tool for the formulation of a natural fungicide that could be used in the agriculture or food industry to protect plant or food products from the contamination by toxigenic fungi such as Fusarium sp. and their potential mycotoxins.

Molecular Mechanisms of Transcription-Coupled Repair.

Transcription-coupled repair (TCR), discovered as preferential nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers located in transcribed mammalian genes compared to those in nontranscribed regions of the genome, is defined as faster repair of the transcribed strand versus the nontranscribed strand in transcribed genes. The phenomenon, universal in model organisms including Escherichia coli, yeast, Arabidopsis, mice, and humans, involves a translocase that interacts with both RNA polymerase stalled at damage in the transcribed strand and nucleotide excision repair proteins to accelerate repair. Drosophila, a notable exception, exhibits TCR but lacks an obvious TCR translocase. Mutations inactivating TCR genes cause increased damage-induced mutagenesis in E. coli and severe neurological and UV sensitivity syndromes in humans. To date, only E. coli TCR has been reconstituted in vitro with purified proteins. Detailed investigations of TCR using genome-wide next-generation sequencing methods, cryo-electron microscopy, single-molecule analysis, and other approaches have revealed fascinating mechanisms.

Effects of UV sensitivity and accelerated photo-aging on stab resistance of ρ-aramid fabrics impregnated with shear thickening fluids (STFs)

The use of Kevlar in the field of ballistic and stabbing protection has been studied by researchers in polymeric composites for this purpose. This study presents complementary knowledge on energy absorption and dissipation in ρ-aramid fabric impregnated with shear thickening fluids (STFs), especially aiming to obtain better protection against impacts that are deeply associated with STFs, as well as color change, accelerated aging (QUV), and penetration depth (drop tower test). In addition, Scanning Electron Microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) was performed. The research shows that there was a good distribution of STF particles on the ρ-Aramid fabric surface, promoting increased friction between the interfilament and the yarns, further increasing performance and, consequently, improving the energy absorption and dissipation mechanism and, also, the penetration effectiveness in relation to non-impregnated ρ-Aramid fabric. Regarding the protection efficiency against UV exposure (250–400 nm region), there was a significantly decreased compared to those non-impregnated Kevlar® woven with STFs. The FTIR analysis showed that the conditions of aging, after exposure to UV, did not produce new functional groups, that is, there was no chemical modification. Finally, Kevlar fabric impregnated with STFs improved penetration depth performance with the blades independent of the blade type with up to 81% increase in resistance. This result was improved due to interactions between the nanoparticles present in STFs, yarns, and even high-performance woven impregnated with shear-thickening fluids.

A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder

Proliferating cell nuclear antigen (PCNA) is a sliding clamp protein that coordinates DNA replication with various DNA maintenance events that are critical for human health. Recently, a hypomorphic homozygous serine to isoleucine (S228I) substitution in PCNA was described to underlie a rare DNA repair disorder known as PCNA-associated DNA repair disorder (PARD). PARD symptoms range from UV sensitivity, neurodegeneration, telangiectasia, and premature aging. We, and others, previously showed that the S228I variant changes the protein-binding pocket of PCNA to a conformation that impairs interactions with specific partners. Here, we report a second PCNA substitution (C148S) that also causes PARD. Unlike PCNA-S228I, PCNA-C148S has WT-like structure and affinity toward partners. In contrast, both disease-associated variants possess a thermostability defect. Furthermore, patient-derived cells homozygous for the C148S allele exhibit low levels of chromatin-bound PCNA and display temperature-dependent phenotypes. The stability defect of both PARD variants indicates that PCNA levels are likely an important driver of PARD disease. These results significantly advance our understanding of PARD and will likely stimulate additional work focused on clinical, diagnostic, and therapeutic aspects of this severe disease.

Diversified mammalian visual adaptations to bright- or dim-light environments.

Photic niche shifts of mammals are associated with changing visual capabilities, primarily mediated by three visual pigments, two (SWS1 and M/LWS) of them for color vision and rhodopsin (RH1) for dim-light vision. To further elucidate molecular mechanisms of mammalian visual adaptations to different light environments, a systematic study incorporating evolutionary analyses across diverse groups and in vitro assays have been carried out. Here, we collected gene sequences for the three opsins from 220 species covering all major mammalian clades. After screening for cone opsin gene losses, we estimated selective pressures on each of the three genes and compared the levels of selection experienced by species living in bright- and dim-light environments. SWS1 pigment is shown to experience accelerated evolution in species living in bright-light environments as has RH1 in aquatic cetaceans, indicating potential shifts for ecological adaptations. To further elucidate the functional mechanisms for these two pigments, we then carried out site-directed mutagenesis in representative taxa. For SWS1, violet and ultraviolet (UV) sensitivity in the pika and mouse are mainly affected by substitutions at the critical sites 86 and 93, which have strong epistatic interaction. For RH1, the phenotypic difference between the sperm whale and bovine sequences is largely contributed by a substitution at site 195, which could be critical for dim-light sensation for deep-diving species. Different evolutionary patterns for the visual pigments have been identified in mammals, which correspond to photic niches, although additional phenotypic assays are still required to fully explain the functional mechanisms.

A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair

XPA is a central scaffold protein that coordinates the assembly of repair complexes in the global genome (GG-NER) and transcription-coupled nucleotide excision repair (TC-NER) subpathways. Inactivating mutations in XPA cause xeroderma pigmentosum (XP), which is characterized by extreme UV sensitivity and a highly elevated skin cancer risk. Here, we describe two Dutch siblings in their late forties carrying a homozygous H244R substitution in the C-terminus of XPA. They present with mild cutaneous manifestations of XP without skin cancer but suffer from marked neurological features, including cerebellar ataxia. We show that the mutant XPA protein has a severely weakened interaction with the transcription factor IIH (TFIIH) complex leading to an impaired association of the mutant XPA and the downstream endonuclease ERCC1-XPF with NER complexes. Despite these defects, the patient-derived fibroblasts and reconstituted knockout cells carrying the XPA-H244R substitution show intermediate UV sensitivity and considerable levels of residual GG-NER (~50%), in line with the intrinsic properties and activities of the purified protein. By contrast, XPA-H244R cells are exquisitely sensitive to transcription-blocking DNA damage, show no detectable recovery of transcription after UV irradiation, and display a severe deficiency in TC-NER-associated unscheduled DNA synthesis. Our characterization of a new case of XPA deficiency that interferes with TFIIH binding and primarily affects the transcription-coupled subpathway of nucleotide excision repair, provides an explanation of the dominant neurological features in these patients, and reveals a specific role for the C-terminus of XPA in TC-NER.

Investigation of the ultrastructures and retinal arrangements of larval stomatopod eyes

Though the transparent apposition eyes of larval stomatopod crustaceans lack most of the unique retinal specializations known from their adult counterparts, increasing evidence suggests that these tiny pelagic organisms possess their own version of retinal complexity. In this paper, we examined the structural organization of larval eyes in six species of stomatopod crustaceans across three stomatopod superfamilies using transmission electron microscopy. The primary focus was to examine retinular cell arrangement of the larval eyes and characterize the presence of an eighth retinular cell (R8), which is typically responsible for UV vision in crustaceans. For all species investigated, we identified R8 photoreceptor cells positioned distal to the main rhabdom of R1-7 cells. This is the first evidence that R8 photoreceptor cells exist in larval stomatopod retinas, and among the first identified in any larval crustacean. Considering recent studies that identified UV sensitivity in larval stomatopods, we propose that this sensitivity is driven by this putative R8 photoreceptor cell. Additionally, we identified a potentially unique crystalline cone structure in each of the species examined, the function of which is still not understood.

Incorporating Photochromic Viologen Derivative to Unprecedentedly Boost UV Sensitivity in Photoelectrochromic Hydrogel.

Developing ultraviolet (UV) radiation sensors featuring high sensitivity, ease of operation, and rapid readout is highly desired in diverse fields. However, the strategies to enhance sensitivity of UV detection remain limited particularly for photochromic materials, which show colorimetric response toward UV irradiation. Guided by our initial goal of facilitating easier handling, we formulated a viologen derivative ([H2L]-SC) incorporating hydrogel-based UV sensor which not only inherits the photochromism of [H2L]-SC but also engenders an unprecedented reversible photoelectrochromic response that is absent in either [H2L]-SC or hydrogel alone. Judicious synergy between photochromic [H2L]-SC and polyacrylamide (PAM) converts the colorimetric response of [H2L]-SC into the electrical resistance change of [H2L]-SC@PAM, which amplifies the UV sensitivity of [H2L]-SC by 2 orders of magnitude. Explicitly, the limit of detection (LOD) for UV decreases from 296.3 mJ/cm2 based on the UV-vis absorption spectra of [H2L]-SC to 2.83 mJ/cm2 derived from the resistance variation of [H2L]-SC@PAM. Moreover, linear correlation between the resistance reduction rate of [H2L]-SC@PAM and UV dose rate can be established, rendering it as a dual platform for quantifying both the accumulated UV dose and the instant dose rate. In addition, the proposed strategy based on constructing photoelectrochromic hybrids offers a new pathway to boost the UV sensitivity that could be universal for other photochromic materials.

Discrete Goldstone bosons

Exact discrete symmetries, if non-linearly realized, can reduce the ultraviolet sensitivity of a given theory. The scalars stemming from spontaneous symmetry breaking are massive without breaking the discrete symmetry, and those masses are protected from divergent quadratic corrections. This is in contrast to non-linearly realized continuous symmetries, for which the masses of pseudo-Goldstone bosons require an explicit breaking mechanism. The symmetry-protected masses and potentials of those discrete Goldstone bosons offer promising physics avenues, both theoretically and in view of the blooming experimental search for ALPs. We develop this theoretical setup using invariant theory and focusing on the maximally natural minima of the potential. For these, we show that typically a subgroup of the ultraviolet discrete symmetry remains explicit in the spectrum, i.e. realized "\`a la Wigner"; this subgroup can be either abelian or non-abelian. This suggests tell-tale experimental signals for those minima: at least two (three) degenerate scalars produced simultaneously if abelian (non-abelian), while the specific ratios of multi-scalar amplitudes provide a hint of the full ultraviolet discrete symmetry. Examples of exact ultraviolet $A_4$ and $A_5$ symmetries are explored in substantial detail.

Organic Single Crystal with High Mobility, Ultrahigh UV Sensitivity, and Fast Time Response

AbstractOrganic semiconductor molecule is a highly promising material system for next‐generation photodetectors due to its tunable absorption, inherent flexibility, and solution and low‐temperature processibility. However, developing organic semiconductor materials for visible‐blind ultraviolet (UV) photodetectors with broad spectral response remains a big challenge. Herein, a novel triphenylamine‐functionalized donor–acceptor–donor (D–A–D) type isoindigo derivative, (E)‐6,6'‐bis(4‐(diphenylamino)phenyl)‐[3,3'‐biindolinylidene]‐2,2′‐dione (BDPBD), is successfully synthesized. The ultrasensitive visible‐blind UV single crystal organic phototransistors (SC‐OPTs) based on the BDPBD micro/nanometer‐sized single crystal using simple solution process for the detection of ultraviolet‐A (UV‐A), ultraviolet‐B (UV‐B), and ultraviolet‐C (UV‐C) UV light showed a highest hole mobility of 0.12 cm2 V−1 s−1, millisecond‐level response time (20 ms), and ultrahigh photoresponsivity, detectivity, and external quantum efficiency up to 2.62 × 106 A W−1, 1.47 × 1017 Jones, and 3.51 × 108%, respectively.

Diarylethene Photoswitches and 3D Printing to Fabricate Rewearable Colorimetric UV Sensors for Sun Protection

AbstractDespite education campaigns linking sun overexposure and skin cancer, it remains one of the leading preventable cancer diagnoses. Skin cancer risk is correlated with overexposure to UV light in sunlight and can be prevented by avoiding exposure. While sun protection can be achieved using sunscreen and clothing, people must be made aware of their risk to facilitate behavior change. Herein, new rewearable UV sensors which overcome the single‐use limitations of other products are presented. These sensors utilize diarylethene photoswitches, which develop a colored appearance upon exposure to UV and are reset to colorless by green light (<10 min). These photoswitches are incorporated into a range of materials, enabling the use of advanced manufacturing to develop highly desirable consumer products. 3D stereolithographic printing is used to prototype sensors, with complex geometries and appealing aesthetics, that can be worn by users. The UV sensitivity of these devices is tuned by incorporating chromophores, meeting the needs of diverse skin types. The colorimetric response allows for direct visual feedback to the user, or quantification using photography, allowing for dosimetry of UV exposure. These new reusable devices aim to reduce people's exposure to UV, while reducing the waste generated by single‐use devices.

Simultaneous Measurement of Ultraviolet Irradiance and Temperature by Employing Optical Fiber SPR Sensor With Ag/ZnO/PDMS Coating

It is a challenging and valuable work to design and manufacture temperature-compensated all-fiber ultraviolet (UV) sensor. In this article, we creatively use a simple and compact optical fiber sensor based on surface plasmon resonance (SPR) for simultaneous detection of UV and ambient temperature. Different coatings [Ag/polydimethylsiloxane (PDMS) and Ag/ZnO/PDMS] are used to split a length of no-core optical fiber (NCF) into two sensing regions, which generates a transmission spectrum with two distinct SPR dips. The proposed sensor achieves a temperature sensitivity of −2.542 nm/°C in the 15 °C–35 °C range and a UV sensitivity of −0.605 nm/(mW/cm2) in the range of 0–17.20 mW/cm2. The matrix established by the wavelength shift of two dips can demodulate UV and temperature changes, and provide temperature compensation for UV detection. In addition, even in surroundings of complex and changeable UV intensity and ambient temperature, the sensor shows excellent stability and repeatability, as well as great potential in UV sensing, providing a reference for the development of multiparameter optical fiber sensors.

Focus on lasers, imaging, microscopy, and nanoscience

Focus on lasers, imaging, microscopy, and nanoscience

Biocontrol of methicillin-resistant Staphylococcus aureus using a virulent bacteriophage derived from a temperate one

Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious threat to global public health due to its resistance to specific antibiotics. Bacteriophages particularly the lytic ones are promoted as a potential powerful-tool to combat infections caused by drug resistant bacteria; while several disadvantages limited the application of the temperate ones. In this study, we isolated 14 phages against MRSA strains, and found three ones showed the capacity of killing most of the target MRSA strains. However, whole genome sequencing and generation of lysogens indicated that these three bacteriophage candidates were temperate ones. Therefore, we mutated one (4PHSA25) of them to a virulent bacteriophage (4PHCISA25). Phenotypical characterization assays revealed that 4PHCISA25 had similar lytic spectrum, temperature, pH, and UV sensitivities to 4PHSA25. However, 4PHCISA25 displayed increased lytic activities and decreased bacteriophage insensitive mutant frequency. Biofilm removing assays showed that 4PHCISA25 exhibited a better capacity than 4PHSA25 on eliminating biofilms formed by MRSA strains. Mouse experiments demonstrated that injection of 4PHCISA25 was safe to the mice and treatment with it (109 PFU per mouse) inhibited the development of abscess induced by MRSA within 24 h and promoted the recovery from the clinical signs. Taken together, this study highlights the use of phages combating MRSA.

A new strategy to minimize humidity influences on acoustic wave ultraviolet sensors using ZnO nanowires wrapped with hydrophobic silica nanoparticles

Surface acoustic wave (SAW) technology has been widely developed for ultraviolet (UV) detection due to its advantages of miniaturization, portability, potential to be integrated with microelectronics, and passive/wireless capabilities. To enhance UV sensitivity, nanowires (NWs), such as ZnO, are often applied to enhance SAW-based UV detection due to their highly porous and interconnected 3D network structures and good UV sensitivity. However, ZnO NWs are normally hydrophilic, and thus, changes in environmental parameters such as humidity will significantly influence the detection precision and sensitivity of SAW-based UV sensors. To solve this issue, in this work, we proposed a new strategy using ZnO NWs wrapped with hydrophobic silica nanoparticles as the effective sensing layer. Analysis of the distribution and chemical bonds of these hydrophobic silica nanoparticles showed that numerous C-F bonds (which are hydrophobic) were found on the surface of the sensitive layer, which effectively blocked the adsorption of water molecules onto the ZnO NWs. This new sensing layer design minimizes the influence of humidity on the ZnO NW-based UV sensor within the relative humidity range of 10–70%. The sensor showed a UV sensitivity of 9.53 ppm (mW/cm2)−1, with high linearity (R2 value of 0.99904), small hysteresis (<1.65%) and good repeatability. This work solves the long-term dilemma of ZnO NW-based sensors, which are often sensitive to humidity changes.