Superhydrophobic surfaces have garnered significant attention for their unique wettability and extensive applications across various critical fields. In this paper, a two-step laser processing technique, involving infrared nanosecond laser patterning and ultraviolet picosecond laser surface modification, was employed to fabricate interconnected frame surfaces with dual-scale microstructures on Ti6Al4V substrates. After that, the microstructure surface was chemically modified with 1H,1H,2H,2H-perfluorodecyl trimethoxy-silane to achieve a superhydrophobic surface. An L32 (47) orthogonal experiment was used to analyze the effect of seven main factors (including the structure size, scanning velocity and the fluence, number of scans of infrared nanosecond laser and ultraviolet picosecond laser) on the wettability of the interconnected frame microstructures surface. After optimization, the surface strongly corresponded with the Cassie-Baxter model and demonstrated a water contact angle of 153.22±1.64° and roll-off angle of 4.43±1.70°. The experiments demonstrated that the optimized surface possesses excellent mechanical stability and corrosion resistance. Additionally, the optimized surface exhibits anti-adhesion, effective self-cleaning, and anti-fouling properties, which hold promise for addressing issues of liquid adhesion and dust pollution in industrial machinery.