The moisture separator reheater (MSR) is a key piece of equipment in reheat systems in nuclear steam turbines that use saturated main steam, where it helps improve turbine efficiency and suppress flow-accelerated corrosion. Fundamental to achieving a compact, reliable MSR design are methods for predicting mist separator vane performance and suppressing tube drainage instability. First, we devised a method for predicting separator performance based on the observation of mist separation behavior under an air-water test. We then developed a method for predicting performance under steam conditions from air-water test data and verified it by means of a comparison with the actual results of a steam condition test. The instability of tube drainage associated with both subcooling and temperature oscillation at turbine partial load, which might adversely affect the seal welding of the tubes to the tube sheet due to thermal fatigue, was measured on an existing unit to clarify the behavior. We then developed a technique for increasing venting steam, which had been operating at a constant flow rate, to suppress instability and verified its effectiveness. Both methods were applied to current MSR models, which were adopted for nuclear power plant turbines commercially placed in service from 1984 to 2009, and the effectiveness of the methods was demonstrated. The separator vane mist carryover rate was less than 0.1%, and tube drainage instability was suppressed, demonstrating the effectiveness of the simple design concept of a two-flow U-tube instead of the prevailing four-flow U-tube design. We put forth a new concept in the design of MSRs for 1700 MW class advanced pressurized water reactor (APWR) units based on associated technologies, along with advanced technology for the compact design of pressure vessels and multidisciplinary optimum design for evaluating heat exchanger tube bundles.