Typical Core-shell Structure Research Articles

Antioxidant Nanomedicine Significantly Enhances the Survival Benefit of Radiation Cancer Therapy by Mitigating Oxidative Stress-Induced Side Effects.

Oxidative stress-induced off-target effects limit the therapeutic window of radiation therapy. Although many antioxidants have been evaluated as radioprotective agents, none of them are in widespread clinical use, owing to the side effects of the antioxidants themselves and the lack of apparent benefit. Aiming for a truly effective radioprotective agent in radiation cancer therapy, the performance of a self-assembling antioxidant nanoparticle (herein denoted as redox nanoparticle; RNP) is evaluated in the local irradiation of a subcutaneous tumor-bearing mouse model. Since RNP is covered with a biocompatible shell layer and possesses a core-shell type structure of several tens of nanometers in size, its lifetime in the systemic circulation is prolonged. Moreover, since 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), one of the most potent antioxidants, is covalently encapsulated in the core of RNP, it exerts intense antioxidant activity and induces fewer adverse effects by avoiding leakage of the TEMPO molecules. Preadministration of RNP to the mouse model effectively mitigates side effects in normal tissues and significantly extends the survival benefit of radiation cancer therapy. Moreover, RNP pretreatment noticeably increases the apoptosis/necrosis ratio of radiation-induced cell death, a highly desirable property to reduce the chronic side effects of ionizing irradiation.

Fabrication of acid-resistant imprinted layer on magnetic nanomaterials for selective extraction of chlorogenic acid in Honeysuckle

The common elution process of molecularly imprinted polymers (MIPs) is carried out in an acidic medium, which greatly affects the stability and reusability of synthetic MIPs, especially for magnetic MIPs. In this study, we fabricated an acid-resistant imprinted layer formed by phase-transitioned lysozyme on magnetic nanomaterials for selective extraction of chlorogenic acid in Honeysuckle, which often coexists with structural analogs. The newly designed acid-resistant imprinted layer can not only protect the internal magnetic core from denudation and dissolution, but also maintain the integrity of the imprinted layer during the elution process. The resultant magnetic MIPs exhibited good stability with no change on morphology after the repeatedly eluting process, and satisfactory reusability that can be used at least ten adsorption-desorption cycles with almost no decrease for adsorption capacity. In addition, the resultant materials possess satisfactory magnetism, uniform morphology with typical core-shell structure, stable crystallization, and good adsorption performance showing on high adsorption amount (10.82 mg g−1), fast kinetic equilibrium time (as short as 30 min), and satisfactory selectivity (IF = 2.85, SC > 1.5). At last, the obtained magnetic MIPs as adsorbents coupled with HPLC were successfully used to selective extract CGA in Honeysuckle samples with the high recoveries in the range of 92.0–104.4%, and the contents of CGA in Honeysuckle samples from the different origin are calculated in the range of 0.98%–1.24%.

Origin of the O phase and its effect on the mechanical properties of rolled Ti-22Al-25Nb alloy sheets

ABSTRACT The microstructure and mechanical properties of a hot-rolled Ti-22Al-25Nb (at%) alloy sheet after aging and solution-aging treatment were studied. A typical core-shell structure formed in the as-received specimens upon aging at 650 °C to 950 °C for 6 h. O phases precipitated around the grain boundaries or in the B2 matrix for the solution-treated specimens upon aging at 650 °C to 950 °C. The combined effect of the precipitation and solution strengthening led to a decrease in microhardness while aging from 650 °C to 900 °C and an increase in microhardness while aging from 900 °C to 1000 °C for both the as-received and solution-treated specimens after the aging treatment. Finer O phases contributed to the increase in yield strength and elongation and were more beneficial to the improvement of high temperature strength than of room temperature strength.

Magnetic imprinted nanoparticles with synergistic tailoring of covalent and non-covalent interactions for purification and detection of procyanidin B2.

A synergistic imprinting strategy of covalent and non-covalent interactions is proposed to prepare magnetic molecularly imprinted polymers (DI-MMIPs) for highly selective separation of procyanidin B2 (PC) from grape seed samples. Dopamine and 3-amino-phenylboronic acid as cooperative functional monomers endow the imprinted sites with synergistic tailoring. Benefiting from the synergistic effect, the DI-MMIPs exhibit enhanced imprinting performance with high adsorption capacity (27.71 mg g-1), fast kinetic equilibrium time (within 30 min), outstanding selectivity (IF = 5.8, SC > 3.2), and satisfactory regeneration ability. In addition, the DI-MMIPs possess good magnetism, uniform morphology with typical core-shell structure, and stable crystallization. Furthermore, the established DI-MMIPs coupled with HPLC-UV (~ 280 nm) method has a wide linearity range of 0.05-200 μg mL-1 with correlation coefficient of 0.9997, high recoveries (> 93.1%) with RSDs from 2.9 to 5.5%, and low LOD (0.0008 μg mL-1). Consequently, this work provides an effective and easily tailored way to fabricate magnetic imprinted nanomaterials with both rapid recognition rate and high selectivity and thus holds great promise to realize the extraction and detection of PC from real samples.

Nanosized CuO encapsulated Ni/Co bimetal Prussian blue with high anti-interference and stability for electrochemical non-enzymatic glucose detection.

Non-enzymatic glucose sensors based on metal oxides are receiving remarkable attention owing to their outstanding characteristics of being easy-to use, low cost, and reusability. However, the disadvantage of weak anti-interference associated with poor selectivity significantly restricts their applicability. Herein, we report a two-step in situ fabrication of nanosized CuO encapsulated Ni/Co bimetal Prussian blue (PB) with a typical core-shell structure, which can be efficiently used for non-enzymatic glucose detection, ascribing to the permeability and abundant active sites of out-shelled crystalline porous Ni/Co PB and the high catalytic activity and conductivity of embedded CuO nanoparticles, afforded by their mutual synergistic interactions. The glassy carbon electrode modified with the hybrid of the CuO-encapsulated Ni/Co PB (simplified as the Ni/Co-PB/CuO/GCE electrode) exhibited a high glucose sensitivity of 600 μA mM-1 cm-2 with a low detection limit of 0.69 μM (S/N = 3), a fast response time (less than 3 s), and excellent long-term stability. In addition, the CuO-encapsulated Ni/Co PB showed favorable anti-interference ability in the presence of ascorbic acid (AA), L-lysine (Lys), dopamine (DA), cysteine (Cys), dopamine (DA), and KCl interferences. The reusability and long-term stability, as well as the practicability of the Ni/Co-PB/CuO/GCE sensing electrode verified by testing real serum samples were also investigated, and the experimental results demonstrated the applicability of the core-shell NiCo-PB/CuO based flexible electrochemical sensor for non-enzymatic glucose sensing in practical applications.

Experimental investigation into the number, micromorphology, functional group composition, and oxidation activity of particles from diesel engine with biodiesel blend

Biodiesel is a promising alternative clean fuel for vehicles. In this paper, comprehensive particulate characteristics, including the particle number (PN), particle mass (PM), particle size distribution, particle micromorphology, chemical functional groups and particle oxidation activity from biodiesel blend B20 (20% biodiesel and 80% diesel by volume), were investigated based on a diesel bus using a heavy chassis dynamometer bench. Results showed that B20 could reduce the PN by 18.8% and the PM by 27.3%. The reduction efficiency of B20 on the accumulation mode particles was higher than that of the nucleation mode ones, which were 43.2 and 7.6%, respectively, thereby causing the proportion of the nucleation mode particles in B20 to increase from 54 to 66% in comparison with that of D100 (pure diesel). In terms of the particle micromorphology, the average fractal dimension of the particles from B20 was higher than that of D100, indicating that the particles from B20 were more compact. The proportion of typical core–shell structure particles in the basic carbon particles of B20 was higher than that of D100, and the coincidence degree between particles was also higher for B20; additionally, B20 preferred to produce basic carbon particles with a regular spherical shape. The graphitization degree of the particles increased with increasing oxidation temperature, but the lattice defect degree decreased. The Raman analysis reflected that the particles of B20 had a higher lattice defect degree but a lower graphitization degree compared with the particles of D100. The ratio of O/C, as well as the sp3/sp2 ratio of the B20 particles, were higher than those of the D100 particles, also indicating that more defects were present in the B20 particles. The particles from B20 exhibited higher oxidation activity in comparison with the particles from D100.

Formation of core-shell type structure in Duplex Martensitic Steel

Microstructures of both as-quenched and intercritical-annealed medium-Mn steel were investigated by transmission electron microscopy to acquire a better understanding of γ–ɛ and γ–α′ martensitic transformations. The orientation relationships among each phases were determined as (1¯10)α′//(0001)ε,[111]α′//[112¯0]ε for the case of as-quenched sample, and (1¯10)α′//(1¯11)γ//(0001)ε,[111]α′//[110]γ//[112¯0]ε for the case of intercritical-annealed sample, respectively. In addition, the presences of core-shell type microstructures with the gradient of Mn concentration were confirmed with ɛ–martensite being surrounded by retained γ. Mn concentration of each phase was found dependent on the growth of reversed γ controlled by Mn diffusion during intercritical annealing. It was strongly suggested that the gradient of Mn concentration occurred during intercritical annealing affected the phase stability, which resulted in the formation of ε/γ core-shell microstructures.

Formation of Core-Shell Type Structure in Duplex Martensitic Steel

Microstructures of both as-quenched and intercritical-annealed medium-Mn steel were investigated by transmission electron microscopy to acquire a better understanding of γ–ɛ and γ–α′ martensitic transformations. The orientation relationships among each phases were determined as (-110)α′//(0001)ɛ, [111]α′//[11-20]epsiron for the case of as-quenched sample, and (-110)α′//(-111)γ//(0001)ɛ, [111]α′//[110]γ//[11-20]ɛ for the case of intercritical-annealed sample, respectively. In addition, the presences of core-shell type microstructures were confirmed with ɛ–martensite being surrounded by γ–austenite. Mn content of phases were found dependent on the solubility limit of Mn of phases by the combination of scanning transmission electron microscopy and energy dispersive X-ray spectroscopy. The γ–austenite grow further by the shifting the interface between γ–austenite and α'–martensite, and forming of Mn depletion zone. Furthermore, the estimated diffusion distance of Mn within with γ–austenite was calculated about 25 nm.

Continuous and controllable synthesis of MnO2/PPy composites with core–shell structures for supercapacitors

A slug-based microreactor system was constructed to integrate the redox reaction between KMnO4 and MnSO4 with the chemical oxidative polymerization of pyrrole for the preparation of MnO2/PPy composite with a typical core–shell structure. MnO2 was formed as the core while PPy acted as the shell. The size distribution variation of MnO2 particles was elaborated by the crystallization theory and the comparison between the micromixing time and the nucleation induction time. It was found that the morphology of the MnO2/PPy composite was significantly affected by the molar ratio among KMnO4, MnSO4 and pyrrole and the residence time due to the competition between the pyrrole polymerization and the MnO2 crystallization. A probable mechanism for the formation of the PPy/MnO2 composite was proposed. The electrochemical performance of the MnO2/PPy composite with core–shell was better than that of MnO2. The enhanced performance demonstrated the synergistic effect between MnO2 and PPy for the fabrication of the core–shell structure. This work developed the design of particles with core–shell structures from the droplet-based microreactor to the slug-based microreactor with a relatively higher flux. The size of the prepared material decreased from microscale in the droplet-based microreactor to nanoscale in this slug-based microreactor. Such a novel strategy can be applied for efficiently preparing functional materials with controllable structures and properties.

Serum protein-hyaluronic acid complex nanocarriers: Structural characterisation and encapsulation possibilities

A protein-polysaccharide-based potential nanocarrier system have been developed via a simple, one-step preparation protocol without the use of long-term heating and the utilization of hardly removable crosslinking agents, surfactants, and toxic organic solvents. To the best of our knowledge, this article is the first which summarizes in detail the pH-dependent quantitative relationship between the bovine serum albumin (BSA) and hyaluronic acid (HyA) confirmed by several physico-chemical techniques. The formation of colloidal complex nanoconjugates with average diameter of ca. 210–240 nm is strongly depend on the pH and the applied BSA:HyA mass ratio. Particle charge titrations studies strongly support the core-shell type structure, where the BSA core is covered by a thick HyA shell. Besides the optimization of these conditions, the drug encapsulation capacity and the dissolution profiles have been also studied for ibuprofen (IBU) and 2-picolinic acid (2-PA) as model drugs.

Study on the Preparation and Anti-CO2 Corrosion Performance of Soap-Free Latex for Oil Well Cement.

To improve the resistance to CO2 corrosion of oil well cement, soap-free emulsion polymerization was used to prepare a soap-free latex (PSAC) with sodium styrene sulfonate (SSS) and nano-SiO2 (SSS/SiO2) as the ionic copolymer emulsifier. The effects of SSS/SiO2 on the performance, thermal stability, and latex particle morphology of the PSAC were investigated through zeta potential, TGA, and TEM measurements, respectively. The carbonation resistance properties of cement with PSAC were evaluated, and the anticorrosion mechanism of the PSAC cement was determined by SEM, EDS, XRD, and 29Si NMR analyses. The results showed that the PSAC particle size was uniform, the particles were monodispersed, and they had a typical core–shell structure and good heat resistance. The carbonation resistance test results showed that after 60 days of corrosion, the corrosion depth of the cement with 12.0% PSAC content was only 2.16 mm, the permeability was 0.0018 mD, and the decrease in the compressive strength was 6.65%. The porosity in the cement was reduced significantly, and the pore volume (>50 nm) of the cement was reduced by 0.24 times. The PSAC film formation decreased the contact between hydration products and CO2. In addition, the nano-SiO2 in the PSAC reacted with Ca(OH)2 to reduce the free Ca(OH)2 content in the cement and generate C–S–H gel with a low Ca/Si ratio and high polymerization, which did not react as readily with CO2.

Failure analysis on octagonal honeycomb sandwich panel under air blast loading

In recent days “honeycomb sandwich panels” are widely used against high intensity blast load due to the high energy absorption capability of the honeycomb structure. In this research paper determined the structural behavior of the honeycomb sandwich panel is subjected to the blast loading. Different honeycomb cores like square and octagonal structures are used to determine the minimum deflections for the top and back plates and also maximum energy absorption for the sandwich panel. The honeycomb sandwich panel is consists of the two solid plates (top plate and bottom plate) and one honeycomb core shell type structure. The blast is applied at a constant standoff distance from top plate of the sandwich panel. The sandwich panel is subjected to the blast load using the different masses of explosive charges such as 1 kg, 2 kg and 3 kg of the Trinitrotoluene (TNT) for the explosion in the air, at a constant standoff point distance from the top plate of sandwich panel. The finite element model is performed by ABAQUS software to determine the dynamic response for the sandwich panel. The quarter part of the honeycomb sandwich structure was modeled and imposed symmetry boundary conditions for the honeycomb sandwich panel to minimize the memory storage of the system and reduced the computation time of the analysis. The top and back face deflections of the square honeycomb sandwich panel have been validated with experimental results available in the literature in square honeycomb sandwich panel. There is a possibility of under estimation of the front face and back face deflections for the sandwich panel, if the honey comb structures are not considered an octagonal sandwich panels for different blast loads.

Revisiting the demagnetization curves of Dy-diffused Nd-Fe-B sintered magnets

The grain boundary diffusion process (GBDP) is now widely used to increase coercivity in Nd-Fe-B sintered magnets with a more efficient use of heavy rare earth elements (Dy, Tb). This process leads to a typical core-shell structure for the grains consisting of (Nd,Dy)2Fe14B shells at the outer grain regions and Nd2Fe14B cores. The thickness of the (Nd,Dy)2Fe14B shells decreases from the diffusion surface to the magnet core. This inhomogeneous distribution in Dy content gives rise to a coercivity gradient within the magnet and leads therefore to a reduced squareness of the demagnetization curve. The purpose of this work is to provide a quantitative understanding of the influence of composition profiles after GBDP on the shape of the demagnetization curve of Nd-Fe-B sintered magnets diffused with the Dy63Co37 (at. %) intermetallic compound. SEM/X-EDS analyses along the Fisher diffusion model allow the estimation of the Dy concentration in grains and at different depths. Then, after ascribing to the grains some critical values for the switching field that are related to the local Dy content, a macroscopic finite element model is implemented to provide a better understanding of the grain reversal sequence in the graded magnets tested in closed-circuit. Grain reversal patterns show that demagnetization starts from the less coercive grains in the magnet core, remains constricted in this zone thanks to a shielding effect from the external surface, and then propagates towards outer layers via magnetostatic interactions. When the coercivity gradient is large, the coercivity of the whole magnet measured in closed-circuit could be 100–200 kA/m lower than the value expected without considering magnetostatic interactions, suggesting that the shielding effect from the diffusion affected layers could be limited and counterbalanced by magnetostatic interactions.

Targeted nanocarriers for mitogen‐activated protein kinase inhibitor delivery to treat coronary artery spasm

Coronary artery spasm (CAS) causes serious ischaemic cardiac disease. The hyper-reactivity of vascular smooth muscle cells, which ascribe the up-regulation of endothelin receptor B type, is a key abnormality responsible for the pathological constriction of arteries in CAS. In this study, the nanocarriers were prepared and optimised for the delivery of U0126, which is an inhibitor of the mitogen-activated protein kinase, to treat pathological constriction of arteries. First, cationic amphipathic starch and hyaluronic acid were used in the encapsulation of U0126 to form U0126 nanoparticles (NPs). The shape of the U0126 NPs was spherical with a typical core–shell structure. The size was 94.1 ± 10.2 nm and the zeta potential was −20.3 ± 5.1 mV. Maximal encapsulation efficiencies and drug loading of U0126 in the NPs were 96.2 ± 3.1 and 8.2 ± 2.5%, respectively. U0126 NPs showed very great stability and could perform an effective targeted delivery. An arterial tissue culture model was used in the investigation of anti-constriction. In comparison with treatment with the free drug, the U0126 NPs significantly decreased the effective dosage, enhanced the effect of anti-constriction, and down-regulated the endothelin type B receptor in the culture model. These results suggest that U0126 NPs have a significant potential for the treatment of CAS.

Synthesis of core–shell soap-free emulsion and evaluation of its performance in oil-well cement

A soap-free latex (XY-5) was prepared by means of a soap-free emulsion free-radical polymerisation method, using the synthetic polymer P (BA/AANa) as an emulsifier and butyl acrylate (BA), styrene and methyl methacrylate as monomers. The stability, thermal stability and microstructure of the XY-5 emulsion were studied using various methods, including viscosity analysis, zeta potential measurement, thermogravimetric analysis and transmission electron microscopy. The emulsion was found to have high stability and good heat resistance, with the latex particles exhibiting a typical core–shell structure. Its performance as an oil-well cement was also evaluated. The results showed that the XY-5–cement slurry has good temperature resistance, salt resistance, low water loss and low permeability. Furthermore, the use of XY-5 effectively improved the cementation strength. Scanning electron microscopy showed that the XY-5 latex forms a three-dimensional network structure inside the cement, with cement particles linked together by latex particles. The comprehensive performance of XY-5 latex was found to be much better than the THD-815 latex on the market.

Biofunctional Polymer Coated Au Nanoparticles Prepared via RAFT-Assisted Encapsulating Emulsion Polymerization and Click Chemistry.

The use of reversible addition-fragmentation chain transfer (RAFT)-assisted encapsulating emulsion polymerization (REEP) has been explored to prepare diverse types of colloidal stable core–shell nanostructures. A major field of application of such nanoparticles is in emergent nanomedicines, which require effective biofunctionalization strategies, in which their response to bioanalytes needs to be firstly assessed. Herein, functional core–shell nanostructures were prepared via REEP and click chemistry. Thus, following the REEP strategy, colloidal gold nanoparticles (Au NPs, d = 15 nm) were coated with a poly(ethylene glycol) methyl ether acrylate (PEGA) macroRAFT agent containing an azide (N3) group to afford N3–macroRAFT@Au NPs. Then, chain extension was carried out from the NPs surface via REEP, at 44 °C under monomer-starved conditions, to yield N3–copolymer@Au NPs–core–shell type structures. Biotin was anchored to N3–copolymer@Au NPs via click chemistry using an alkynated biotin to yield biofunctionalized Au nanostructures. The response of the ensuing biotin–copolymer@Au NPs to avidin was followed by visible spectroscopy, and the copolymer–biotin–avidin interaction was further studied using the Langmuir–Blodgett technique. This research demonstrates that REEP is a promising strategy to prepare robust functional core–shell plasmonic nanostructures for bioapplications. Although the presence of azide moieties requires the use of low polymerization temperature, the overall strategy allows the preparation of tailor-made plasmonic nanostructures for applications of biosensors based on responsive polymer shells, such as pH, temperature, and photoluminescence quenching. Moreover, the interaction of biotin with avidin proved to be time dependent.

Interconnected graphene scaffolds for functional gas sensors with tunable sensitivity

In this work, the interconnected graphene scaffolds are prepared by three-dimensional (3D) printing for multifunctional gas detection with tunable sensitivity. The scaffolds with regularly aligned graphene conductive networks exhibit significant mechanical strength and high electrical stability to multi-direction deformation, which can be attributed to the typical core-shell structure of graphene and PVP. The resistance of the free-standing scaffolds can realize the real-time response to H2O and NO2, and the relative resistance change to 100 ppm H2O and 100 ppm NO2 can reach 2% and 2.5 %, respectively. The charge doping of the oxidizing gases is considered to be the main reason for various response sensitivities of the scaffolds with different orthogonal layers, in which the interconnected conductive network can generate a large specific surface area and significantly improving the adsorption of the target gases and the transfer of charge. The controllable fabrication of regular structure has appropriately great potential for further optimizations and applications in gas detection.

Influence of Secondary Organic Coating on Hygroscopicity of a Sodium Chloride Core: Based on Mircro-scale Single Particle Analysis

The hygroscopicity of atmospheric particulate matter can determine its optical behaviors, cloud condensation nuclei activity, and heterogeneous chemical reaction on the surface. However, the effect of secondary organic matter on the hygroscopicity of inorganic salts is still rarely studied. In this study, a 2 L gas-phase flow tube was used to stimulate the oxidation process of α-pinene. NaCl particles at the end of the flow tube served as seeds to absorb the product of α-pinene oxidation. The absorption times were 11, 15, and 20 h. Transmission electron microscopy results show that this system could produce particles with typical core-shell structure, and that the thickness of the organic shell would be thicker with longer collection time. Results from individual particle hygroscopic systems indicate that the organic shell can affect the deliquescent point of NaCl (pure NaCl deliquesces at 77%):for 11 h collection time, the NaCl core began to deliquesce at 75.5% relative humidity, and completely deliquesced at 78%; for 15 h collection time, the deliquescent range of the NaCl core was 75%-78.5%; and the deliquescent range was 76%-83% for the NaCl core with 20 h collection time. Furthermore, the organic shell could affect the hygroscopic growth of the NaCl core:the growth factor of the NaCl core with 11 h, 15 h, and 20 h collection time was 2.5, 2.3, and 1.8, respectively. These results indicate that:① the secondary organic shell could cause water absorption of the NaCl core in advance:② the organic shell could postpone the completely deliquescent point of the NaCl core, and this effect is more obvious with a thicker organic shell; ③ the organic shell could restrain the hygroscopic growth factor of the NaCl core. This study suggests that it is necessary to consider the influence of secondary organic matter on inorganic salts when studying the hygroscopic properties of atmospheric particles in climate models and field observations.

Optimizing the electromagnetic wave absorption performances of designed Fe3O4@SiO2@MnO2 hybrids

Whereas growing numbers of strong-absorption materials have been synthesized in recent years, it is also necessary to design broad-bandwidth, low-thickness, high-intensity absorbers. The ternary Fe3O4@SiO2@MnO2 hybrids were fabricated via hydrothermal and hydrolysis processes, combined with typical core-shell structure characteristics and heterogeneous properties, further generating interfacial polarization behavior and enhancing anisotropy. Investigations of micromorphology manifested the hierarchical characteristic via the presence of inner mesoporous Fe3O4 cores, outer SiO2 layers (approximately 10 nm) and MnO2 nanosheets as the surface of the hybrids. On the basis of rational design, the optimized multi-layers absorber exhibited excellent absorption performance with optimal reflection loss (RLmin) of −50.2 dB at 13.9 GHz, and the effective absorption band (EAB) is up to 5.1 GHz from 11.5 GHz to 16.6 GHz with the thickness of 2.6 mm. Due to the large surfaces, high porosity as well as the synergistic effect derived from the magnetic Fe3O4 cores and dielectric SiO2@MnO2 layers, this effective strategy may be endowed with high potential to design high-efficient absorbers.

Naringin-loaded polymeric micelles as buccal tablets: formulation, characterization, in vitro release, cytotoxicity and histopathology studies

Naringin (NG) has been proved to have numerous notable biological effects, including anti-inflammatory effect, anti-cancer effect, and anti-ulcer effect, yet there are no clinical preparations of naringin due to its poor solubility and low dissolution rate after oral administration. In this study, in order to overcome these problems, NG was encapsulated into MPEG-PCL micelles (NGMs) by using a thin-film hydration method. NMGs were in a typical core-shell structure, with a mall particle size (23.95 ± 0.51 nm), high drug loading, and encapsulation efficiency. In vitro release of NGMs indicated that the dissolution of NG was increased after being encapsulated in the micelles. NGMs were nontoxic in the cytotoxicity and histopathology studies. Furthermore, when the freeze-dried NGMs were compressed into buccal tablets (NGBTs) by direct compression, the release speed of NG under simulated oral cavity condition from NGBTs was higher than the control tablets, with the accumulated dissolution at 93.13% in 8 hours. In conclusion, NGMs and NGBTs represent a promising drug delivery system for NG, which has the potential to improve the current treatment of oral diseases.