Typical Constituents Research Articles

Insights into the generation of multiple reactive species in UV254/PMS/I− system and their roles for degradation of phenolic and non-phenolic pollutants

An innovative technology for the removal of phenolic and non-phenolic organic pollutants from aqueous solution was developed by combining UV254 irradiation, peroxymonosulfate (PMS), and iodide ions (I−). Effects of pH, ratio of [I−]/[PMS], initial concentration of pollutant, dissolved organic matter (DOM) and typical inorganic constituents of environmental water on the degradation of studied pollutants with UV254/PMS/I− system were examined. The results showed that pH and [I−]/[PMS] exhibited significant impact on the degradation of pollutants during UV254/PMS/I− process. As the ratio of [I−]/[PMS] increased from 0.1 to 10.0, the removal efficiencies of phenolic pollutants remarkably increased, but those of non-phenolic pollutants decreased. The DOM at high concentration obviously inhibited the degradation of pollutants during UV254/PMS/I− process. Meanwhile, the occurrence of NO3− can slightly enhance the degradation of pollutants, and SO42−, Cl−, and HCO4− ions had no significant effects on UV254/PMS/I− system. The abundant reactive species including OH, SO4−, and I/I2− during UV254/PMS/I− process were generated based on electron spin resonance, fluorescence spectroscopy and steady-state concentration analysis. Quenching experimental results indicated that I/I2− can selectively degrade phenolic pollutants via one-electron oxidation. This study provided a reference for the application of reactive radicals involved oxidative technique in water purification.

Directing-Group-Assisted Non-Strained Ether C-O Bond Homolysis Mediated by Low-Valent Titanium.

Ether C-O bonds are typical constituents of organic molecules that are seldom regarded as reactive functional groups except when highly strained. With the assistance of appropriate directing groups, low-valent titanium was found to homolytically cleave non-strained C-O bonds. In particular, a newly designed catechol monoether directing group rendered a route toward the activation of non-benzylic C(sp3)-O bonds. This method has been applied to conventional radical addition reactions to alkenes.

Pseudomonas spp. in Canine Otitis Externa.

Canine otitis externa (OE) is a commonly diagnosed condition seen in veterinary practice worldwide. In this review, we discuss the mechanisms of the disease, with a particular focus on the biological characteristics of Pseudomonas aeruginosa and the impact that antibiotic resistance has on successful recovery from OE. We also consider potential alternatives to antimicrobial chemotherapy for the treatment of recalcitrant infections. P. aeruginosa is not a typical constituent of the canine ear microbiota, but is frequently isolated from cases of chronic OE, and the nature of this pathogen often makes treatment difficult. Biofilm formation is identified in 40-95% of P. aeruginosa from cases of OE and intrinsic and acquired antibiotic resistance, especially resistance to clinically important antibiotics, highlights the need for alternative treatments. The role of other virulence factors in OE remains relatively unexplored and further work is needed. The studies described in this work highlight several potential alternative treatments, including the use of bacteriophages. This review provides a summary of the aetiology of OE with particular reference to the dysbiosis that leads to colonisation by P. aeruginosa and highlights the need for novel treatments for the future management of P. aeruginosa otitis.

Bioactivities and chemical profiling comparison and metabolomic variations of polyphenolics and steroidal glycoalkaloids in different parts of Solanum nigrum L.

Solanum nigrum L. is a traditional medicinal herb and edible plant. Many studies provide evidence that S. nigrum L. is a nutritious vegetable. Polyphenols and steroidal glycoalkaloids are the main components. This study aimed to systemically evaluate the phytochemical profile, quantification, and bioactivities of polyphenolics and glycoalkaloids in different parts of S. nigrum L. Total polyphenols (TPC) and total glycoalkaloids (TGK) were determined using the Folin-Ciocalteu and acid dye colorimetric methods, respectively. A total of 55 polyphenolic constituents (including 22 phenolic acids and 33 flavonoids) and 24 steroidal glycoalkaloids were identified from different parts using ultrahigh-performance liquid chromatography Q-exactive high-resolution mass spectrometry (UHPLC-QE-HRMS), of which 40 polyphenols (including 15 phenolic acids and 25 flavonoids) and one steroidal glycoalkaloid were characterised for the first time in S. nigrum L. Moreover, typical polyphenols and glycoalkaloids were determined using HPLC-UV and HPLC-evaporative light-scattering detector (ELSD), respectively. In addition, the TPC and TGK and their typical constituents were compared in different anatomical parts. Finally, the antioxidant capacities of polyphenolic extracts from different parts of S. nigrum L. were evaluated by ·OH, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric-reducing antioxidant power (FRAP) assay in vitro. In addition, the antitumour effects of TGK from different parts of S. nigrum L. on the proliferation of PC-3 cells were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Polyphenolic and glycoalkaloid extracts from different parts of S. nigrum L. showed different antioxidant and cytotoxic capacities in vitro. This is the first study to systematically differentiate between polyphenolic and glycoalkaloid profiles from different parts of S. nigrum L.

An accurate and unified study on non-symmetric tensile and compressive responses of elastoplastic bars and beams until failure

A new and unified approach is proposed toward accurately analyzing overall elastoplastic responses of axially loaded bars and finite bending beams until failure. Results are presented for various constituent materials such as metals, reinforced concretes and reinforced composites, etc. Novelties in three respects are incorporated: (a) new uniaxial stress–strain functions are first presented in explicit forms for the purpose of accurately characterizing non-symmetric tensile and compressive behaviors of axially loaded bars from hardening to softening; (b) explicit solutions to both the varying neutral axis and the flexural moment of finite bending beams are then obtained directly in terms of these two uniaxial functions; and, hence, (c) the complex bending problem of various beams until failure is in a unified manner reduced to a simple issue of fitting two uniaxial functions to tension and compression data from uniaxial testing, thus bypassing the analytical and numerical complexity of various existing approaches. Numerical examples of model predictions are provided for typical constituent materials, including aluminium, meso-scopic heterogeneous concrete and ultra-high performance fiber-reinforced concrete with reinforcing rebars. Good agreement is achieved simultaneously with all experimental data for bars and beams made of these materials.

Qualitative and quantitative studies on chemical constituents of Ling-gui-zhu-gan decoction: In vitro and in vivo.

Ling-gui-zhu-gan decoction has significant therapeutic effects in the treatment of diseases related to phlegm and fluid retention. In this study, we aimed to qualitatively characterize the chemical constituents of Ling-gui-zhu-gan decoction in vitro and in vivo by HPLC coupled to Fourier transform ion cyclotron resonance MS, and quantitively determine the contents of typical chemical constituents by HPLC method. As a result, a total of 75 chemical constituents were discovered including 37 flavonoids and their glycosides, 20 saponins, 9 sterols, 3 organic acids and their derivatives, 3 lactones, 2 coumarins, and 1 alcohol. Among them, 17 chemical constituents were specifically identified. Subsequently, an HPLC method was established for simultaneous determination of seven chemical constituents. Finally, a total of 40 prototype components were initially detected by HPLC-MS method in the biological samples of rats after their water extract was orally administrated. Among them, 29, 27, 12, and 32 prototype components were detected in plasma, bile, urine, and feces, respectively. Moreover, 34 metabolites, including 16 phase II metabolites, were detected for the first time. In conclusion, this study lays the foundation for the identification of chemical components in vitro and in vivo and the elucidation of the potential pharmacodynamic components of Ling-gui-zhu-gan decoction.

Assessing pyrolysis performance and product evolution of various medical wastes based on model-free and TG-FTIR-MS methods

The COVID-19 pandemic has caused a substantial rise in the amount of medical waste, posing additional hurdles in waste management. Disposing of this waste properly is essential to curb transmission of the diseases. The pyrolysis reaction kinetics, synergistic interactions, and pyrolysis gas release behavior of typical constituents of medical waste (MW): syringe (SY), medical gloves (MG), cotton swab sticks (CS), and their blends were examined by utilizing advanced analytical techniques including TG, TG-FTIR, TG-MS, and kinetic models (Friedman, KAS). The experiments were conducted using a wide range of heating rates, namely 10, 20, 30, and 40 °C⋅min−1. The pyrolysis reactions were mainly endothermic, with main stages ranging from 352.0–480.0 °C, from 381.0–511.0 °C, from 200.0–404.5 °C, 336.6–509.9 °C, 375.4–477.6 °C, 384.0–500.9 °C, for SY, MG, CS, SY5MG5, SY7CS3, and MG7CS3, respectively. According to the KAS method, the average activation energies for the mono-pyrolysis of SY, MG, and CS were determined as 240.8, 226.1, and 147.5 kJ⋅mol−1 respectively. Interestingly, during the pyrolysis of blends such as SY5MG5, SY7CS3, and MG7CS3, the activation energies decreased to 177.2, 159.9, and 149.1 kJ⋅mol−1 respectively. Notably, the experimental activation energy values (Eexp) obtained during the co-pyrolysis were significantly lower than the calculated values (Ecal), revealing an apparent synergistic effect during the pyrolysis of various MW blends. The pyrolysis process of MW blends resulted in the release of significant volatile components, including CH4, CO, C3H6, CO2, C2H5OH, C4H8, C5H8, C6H6, C6H14, C7H8, and C8H10. The specific composition of these volatile components varied depending on the types of waste present in the blends.

Kinetics and product identification of water-dissolved nitroguaiacol photolysis under artificial sunlight.

Nitroguaiacols are typical constituents of biomass-burning emissions, including absorbing aerosols which contribute to climate change. Although they are also harmful to humans and plants, their atmospheric fate and lifetimes are still very speculative. Therefore, in this work, the photolysis kinetics of aqueous-phase 4-nitroguaiacol (4NG) and 5-nitroguaiacol (5NG), and the resulting photo-formed products were investigated under artificial sunlight, observing also the effect of sunlight on the absorption properties of the solutions. We found the photolysis of 5NG slower than that of 4NG, whereas the absorbance in the visible range prevailed in the 5NG solutions at the end of experiments. Although we identified dinitroguaiacol as one of the 4NG photolysis products, which increased light absorption of 4NG-containing solutions, considerably more chromophores formed in the 5NG photolyzed solutions, implying its stronger potential for secondary BrC formation in the atmosphere. In general, denitration, carbon loss, hydroxylation, nitration, and carbon gain were characteristic of 4NG phototransformation, while carbon loss, hydroxylation, and carbon gain were observed in the case of 5NG. The photolysis kinetics was found of the first order at low precursor concentrations (<0.45mM), resulting in their lifetimes in the order of days (125 and 167h illumination for 4NG and 5NG, respectively), which suggests long-range transport of the investigated compounds in the atmosphere and proposes their use as biomass-burning aerosol tracer compounds.

Thermal plasma processing of high temperature insulation wools

High temperature insulation wool (HTIW) wastes, generated in large volume as a part of demolition and construction processes, are difficult to recycle and pose significant hazards to health and environment. Alkaline earth silicate wools (AESW) and alumino silicate wools (ASW) are the two major types. Typical constituents include silica and oxides of Ca, Al and Mg etc. in varying ratios, giving rise to their specific colours and inherited thermo-physical properties. Successful mitigation and reuse of such wools have not been explored enough. Possibly for the first time, the study makes an extensive investigation on air plasma mitigation of four most commonly used HTIW, namely, fresh rock wool, waste rock wool, waste stone wool and waste ceramic wool. This is a single step dry process. Use of freely available ambient air to generate plasma, extremely high enthalpy, presence of nascent atomic and ionic species and extremely high temperature make the process fast, efficient, economic and unique one to convert such wastes into valorised product. While the thermal field delivered by an air plasma torch has been derived from magneto-hydrodynamic simulation, the study makes a direct in-situ investigation of the evolution of thermal field in the melting zone using two colour pyrometer, and characterises the vitreous solidified end product using X-diffraction, Scanning Electron Microscopy, Energy Dispersive X-ray Analysis, Energy Dispersive X-ray Fluorescence Spectroscopy and Neutron Activation Analysis. Possible valorisation and use of the end product have been discussed in light of their observed elemental composition.

러시아와 EU 간의 에너지 협력과 갈등에 대한 소고

Energy policies are planned in consideration of a number of factors that meet various social needs. Typical constituent factors are energy security, environmental sustainability, and energy equity. Energy cooperation between Russia and the EU is also a key issue. The Corona pandemic and the Russia-Ukraine war are having a huge impact on both Russia and the EU. War, not only Russia, but also the EU thinks that the balance of peace can be upset rather than maintaining the geopolitical balance. However, energy is required for industrial development and maintenance, and a significant part of the required energy is dependent on Russia. To avoid these risks, the EU is actively pursuing the establishment of a decarbonized energy system and the energy transition. Russia is also responding by diversifying its exports. Importantly, both Russia and the EU are at an inflection point for energy policy changes. Therefore, it can be said that a clear analysis of the changes in energy policies in Russia and the EU is necessary because the policy changes of both camps have a great impact on the global economy.

Effects of post-fracture repeated impacts and short-term temperature gradients on monolithic glass elements bonded by safety films

Weathering and operational conditions, as known, have significant impact on typical constituent materials which are used for many construction applications. Among others, structural glass solutions can suffer for these effects in terms of major modification of material properties of interlayers, bonds, connections, gaskets and polymeric components in general. In this paper, the attention is given to the effects of repeated low-amplitude impacts and short-term temperature gradients for the characterization of load-bearing capacity in monolithic glass elements retrofitted by safety films. Especially for existing glass systems which are made of monolithic glass with limited strength and resistance capacity against ordinary and accidental mechanical loads, safety films are commercially available for retrofit interventions. They are primarily expected to keep together glass fragments in case of breakage, and thus minimize possible injuries. Besides, after first fracture, the so obtained glass-film composite elements have uncertain residual mechanical capacity against ordinary loads, given that it mostly depends on thin films composed of Polyethylene terephthalate (PET)-layers and pressure sensitive adhesives (PSAs). To this aim, a set of experiments (for a total of 950 configurations) is carried out in laboratory conditions (30 °C) on small-scale samples of fractured annealed monolithic glass elements bonded by commercial safety films, under repeated low-amplitude impacts / vibrations (S1-TR series), or additionally subjected to preliminary short-term thermal gradients (S2-TC1 series cooled at +5 °C and S3-TC2 series at −20 °C). Localized impacts are quantified in acceleration peaks in the range of 2 ÷ 14 m/s2 and rotations at supports in the order of 15 ÷ 20°. The interpretation of dynamic experimental results is carried out in terms of post-fracture vibration frequency (based on classical operational modal analysis techniques) and used, with the support of simplified analytical models or Finite Element (FE) numerical simulations, to characterize the response of cracked glass-film samples. Most importantly, the vibration frequency decrease is used to quantify their residual load-bearing capacity under unfavourable conditions, and to quantify the post-critical benefit of thin bonding safety films under unfavourable conditions.

Effectiveness of Machine-Learning and Deep-Learning Strategies for the Classification of Heat Treatments Applied to Low-Carbon Steels Based on Microstructural Analysis

This work aims to compare the effectiveness of different machine-learning techniques for the image classification of steel microstructures. For this, we use a set of samples of hypoeutectoid steels subjected to three heat treatments: annealing, quenching and quenching with tempering. Logically, the samples contain the typical constituents expected, and these are different for each treatment. Images are obtained by optical microscopy at 400× magnification and from different low-carbon steels to generate the data with some heterogeneity. Learning models are created with an image dataset for classification into three classes based on the respective heat treatments. Likewise, we develop two kinds of models by using, on the one hand, classical machine-learning methods based on the “bag of features” technique and, on the other hand, convolutional neural networks (CNN) with a transfer-learning approach by using GoogLeNet and ResNet50. We demonstrate the superiority of deep-learning techniques (CNN) over classical machine-learning methods.

Intestinal Epithelial Protective Chalone Glycoside from the Roots of Glycyrrhiza uralensis

: : Glycyrrhiza uralensis has been used as a traditional medicine for generations. Chalcones are one of the typical chemical constituents of G. uralensis. In this paper, phytochemical research on roots of G. uralensis was performed, leading to the isolation and identification of a previously undescribed chalcone glycoside (1). Its structure was established by means of comprehensive spectral analysis and acid hydrolysis. Moreover, bioactivity assay revealed that 1 showed a promotive effect on IEC-6 cell proliferation and evidently reversed DFMO-driven IEC-6 cell growth arrest. The results indicate that 1 might be used for the maintenance of intestinal epithelial homeostasis.

Ablation oxidation and surface quality during laser polishing of TA15 aviation titanium alloy

TA15 titanium alloy is sensitive to temperature, and it is one of the main materials used in aircraft bearing parts that operate for long periods of time at 500 °C. The thermomechanical processing of this alloy is difficult to control because of its high activity and oxidation. In the present research, nanosecond pulse lasers of various powers were used to polish the TA15 surface. The surface morphology, microstructure evolution, oxidation depth and mechanical properties were investigated. The results revealed that the initial sample has a rough surface, and both high-power and low-power lasers can significantly decrease the surface roughness. Three methods, SEM morphology analysis, EDS line scanning and EDS mapping, are used to detect the oxidation depth of the polished zone. The TEM images and XRD patterns show typical Al2O3, Ti2O3 and TiO2 constituents, which affect the tensile strength of the alloy. A low-power laser has a better polishing effect than a high-power laser; the oxidation depth with a high power is approximately 100 μm, while the oxidation depth with a low power is less than 10 μm. The polished surface roughness parameters Ra (arithmetical mean deviation of the profile) and Sa (arithmetical mean height of the scale limited surface) obtained with a low-power laser are reduced from approximately 6 μm–3.197 μm and 4.298 μm, respectively.

Viruses in sanctuary chimpanzees across Africa.

Infectious disease is a major concern for both wild and captive primate populations. Primate sanctuaries in Africa provide critical protection to thousands of wild-born, orphan primates confiscated from the bushmeat and pet trades. However, uncertainty about the infectious agents these individuals potentially harbor has important implications for their individual care and long-term conservation strategies. We used metagenomic next-generation sequencing to identify viruses in blood samples from chimpanzees (Pan troglodytes) in three sanctuaries in West, Central, and East Africa. Our goal was to evaluate whether viruses of human origin or other "atypical" or unknown viruses might infect these chimpanzees. We identified viruses from eight families: Anelloviridae, Flaviviridae, Genomoviridae, Hepadnaviridae, Parvoviridae, Picobirnaviridae, Picornaviridae, and Rhabdoviridae. The majority (15/26) of viruses identified were members of the family Anelloviridae and represent the genera Alphatorquevirus (torque teno viruses) and Betatorquevirus (torque teno mini viruses), which are common in chimpanzees and apathogenic. Of the remaining 11 viruses, 9 were typical constituents of the chimpanzee virome that have been identified in previous studies and are also thought to be apathogenic. One virus, a novel tibrovirus (Rhabdoviridae: Tibrovirus) is related to Bas-Congo virus, which was originally thought to be a human pathogen but is currently thought to be apathogenic, incidental, and vector-borne. The only virus associated with disease was rhinovirus C (Picornaviridae: Enterovirus) infecting one chimpanzee subsequent to an outbreak of respiratory illness at that sanctuary. Our results suggest that the blood-borne virome of African sanctuary chimpanzees does not differ appreciably from that of their wild counterparts, and that persistent infection with exogenous viruses may be less common than often assumed.

Qualitative Analysis Related to Palynological Characterization and Biological Evaluation of Propolis from Prespa National Park (Greece).

Propolis samples from a geographical part of northwest Greece (Prespa National Park, PNP), which is characterized as a plant endemism center and biodiversity hotspot, were characterized through pollen analysis, chemically analyzed, and biologically evaluated. The majority of the studied propolis showed typical chemical constituents (phenolic acids, flavonoids, and chalcones) of European type, while a sample of Mediterranean-type propolis (rich in diterpenes) was also identified. The palynological characterization was implemented to determine the botanical origin and to explain the chemical composition. The total phenolic content and the DPPH assay showed that the European-type propolis samples possessed strong antioxidant activity (86–91% inhibition at 200 μg/mL). Moreover, promising antibacterial activity of the extracts (MIC values 0.56–1.95 mg/mL) and moderate antifungal activity (MIC values 1.13–2.40 mg/mL) were noticed, while the sample with the highest activity had a significant content in terpenes (Mediterranean type). Propolis samples from the PNP area represent a rich source of antibacterial and antioxidant compounds and confirm the fact that propolis is a significant natural product with potential use for improving human health and stimulating the body’s defense. Finally, it is noteworthy that a significant chemical diversity was demonstrated, even in samples from a limited geographical area as this of PNP.

The Urobiomes of Adult Women With Various Lower Urinary Tract Symptoms Status Differ: A Re-Analysis.

The discovery of the urinary microbiome (urobiome) has created opportunities for urinary health researchers who study a wide variety of human health conditions. This manuscript describes an analysis of catheterized urine samples obtained from 1,004 urobiome study participants with the goal of identifying the most abundant and/or prevalent (common) taxa in five clinically relevant cohorts: unaffected adult women (n=346, 34.6%), urgency urinary incontinence (UUI) (n=255, 25.5%), stress urinary incontinence (SUI) (n=50, 5.0%), urinary tract infection (UTI) (n=304, 30.4%), and interstitial cystitis/painful bladder syndrome (IC/PBS) (n=49, 4.9%). Urine was collected via transurethral catheter and assessed for microbes with the Expanded Quantitative Urine Culture (EQUC) technique. For this combined analytic cohort, the mean age was 59 ± 16; most were Caucasian (n=704, 70.2%), Black (n=137, 13.7%), or Hispanic (n=130, 13.0%), and the mean BMI was 30.4 ± 7.7. Whereas many control or IC/PBS cohort members were EQUC-negative (42.4% and 39.8%, respectively), members of the other 3 cohorts were extremely likely to have detectable microbes. The detected urobiomes of the controls and IC/PBS did not differ by alpha diversity or genus level composition and differed by only a few species. The other 3 cohorts differed significantly from the controls. As expected, Escherichia was both prevalent and highly abundant in the UTI cohort, but other taxa also were prevalent at more moderate abundances, including members of the genera Lactobacillus, Streptococcus, Staphylococcus, Corynebacterium, Actinomyces, and Aerococcus. Members of these genera were also prevalent and highly abundant in members of the UUI cohort, especially Streptococcus anginosus. Intriguingly, these taxa were also detected in controls but at vastly lower levels of both prevalence and abundance, suggesting the possibility that UUI-associated symptoms could be the result of an overabundance of typical urobiome constituents. Finally, prevalence and abundance of microbes in the SUI cohort were intermediate to those of the UUI and control cohorts.These observations can inform the next decade of urobiome research, with the goal of clarifying the mechanisms of urobiome community composition and function. There is tremendous potential to improve diagnosis, evaluation and treatment for individuals affected with a wide variety of urinary tract disorders.

ITRAQ-based quantitative proteomic analysis in liver of Pomacea canaliculata induced by oleanolic acid stress.

Triterpene acid is one of the typical active constituents of Eucalyptus bark, which is the main by-product of the Eucalyptus wood industry. Our studies have demonstrated that triterpene acid stress could inhibit climbing and increase mortality in Pomacea canaliculata (Lamarck). However, limited attention has been paid to the proteomic responses of this snail under triterpene acid stress. Using iTRAQ-based quantitative proteomics, we elucidated the regulatory mechanism in the livers of P. canaliculata held in chlorine-free water and exposed to 100 mg L-1 oleanolic acid (OA) for 24 h. A total of 4308 proteins were identified, of which 274 were differentially expressed proteins (DEPs) including 168 (61.31%) differentially upregulated proteins and 106 (38.69%) differentially downregulated proteins. Bioinformatics analysis revealed that P. canaliculata responses to OA stress are mainly involved in glucose metabolism, energy synthesis, immune response, stress response, protein synthesis, and apoptosis. According to KEGG analysis, the 274 DEPs were mapped to 168 KEGG pathways and 10 KEGG pathways were significantly enriched (P < 0.05). Furthermore, qRT-PCR was performed for histone H4, catalase, isocitrate dehydrogenase, superoxide dismutase, ferritin, lipase, and tropomyosin to validate the iTRAQ results. Proteomic analysis suggested that OA stress led to the disruption of glucose metabolism, energy synthesis, and protein synthesis, and triggered a series of molecular pathways containing many key proteins involved in the immune process, thereby helping P. canaliculata resist OA stress. © 2022 Society of Chemical Industry.

Drop‐Casting Halide Microcrystals Enabled by Green Glycol Solvent for High‐Performance Photodetectors

Halide perovskites have attracted significant recent attention due to their remarkable photoelectric properties; however, the poor structural and moisture stability limit their use for practical utilization. Interestingly, binary halides, such as BiI3 and PbI2, are the typical constituents of halide perovskites, where they do not only have the similar outstanding properties of perovskites but also the superior stability. Herein, the synthesis of layered BiI3 and PbI2 microcrystals by simple drop‐casting is investigated and their enhanced photoelectric performance compared to the thin‐film counterparts obtained by conventional spin‐coating is demonstrated. For the formation of high‐quality layered microcrystals, the keys are adopting glycol as a green solvent and appropriate temperature during processing. Once configured into photodetectors, the BiI3 and PbI2 microcrystals exhibit a higher photocurrent, on/off current ratio, responsivity, and other performance parameters than their thin‐film devices. These improved performances of microcrystals can be attributed to their superior crystallinity, thanks to the excellent solvent properties of glycol and the optimal growth temperature chosen. This work proposes a more simple and effective solution processing technique to fabricate layered binary halides with higher quality than the conventional spin‐coating method, enabling the further development of halides‐based optoelectronic devices.

Cardiovascular risk factor insights into the Tesco 1.0 Dataset

Abstract Funding Acknowledgements Type of funding sources: None. Background Tesco published an open-source dataset containing area-aggregated product purchase information from 420m transactions across 16m individual Clubcard users in the Great London area, at a borough level. This dataset is presented as a ‘typical product’ purchase for each borough, divided into 220 individual datapoints. Purpose We wanted to explore dietary correlates with cardiovascular outcomes including age-standardised mortality rates for myocardial infarct, stroke, cardiac arrhythmia and COVID-19. Methods The Tesco 1.0 dataset was accessed on 1/11/21 and a sample of traditional dietary clinical risk and protective factor datapoints for each London borough were selected. Data for age-standardised mortality rates (ASMR) in each London borough were downloaded from the Office of National Statistics for 2019 for myocardial infarction, stroke, cardiac arrhythmia and 2020 COVID-19 deaths (March-July 2020). To explore for relevant associated factors, the average deprivation index (IMD) for each borough was accessed from Public Health England, and demographic data accessed from the Greater London Authority database. Statistics using Spearman’s Rho calculator were derived in Excel and calculated using a web-based statistics calculator. Results Myocardial infarction (MI) ASMR closely correlated with increased levels of salt (g), fat and oils (% of total product), and weight of purchase (g). Increased fibre (g) was correlated with lower MI mortality. An important associated risk factor was the deprivation index, a important co-variable to consider when assessing diet-health relationships. Stroke ASMR was more closely correlated with typical product constituents, significant risk factors were weight (g) of fat, carbohydrate, sugar and ready meals (%) and sweets (%), while % of fish and both % and total weight (g) of fruit and veg were protective factors. Importantly salt content was NOT a statistically significant factor. Cardiac arrhythmia ASMR did not correlate with any dietary constituents reviewed. COVID ASMR was closely correlated with myocardial infarction ASMR risk factors (salt, % of fat and oils and total weight of purchase) and total fibre (g) was again a protective factor. Interestingly, the % of ready meals was a protective factor for COVID ASMR, possibly associated with cultural and ethnicity-related behaviours, with higher BAME communities less likely to purchase ready meals. Conclusions This unique dataset offers a Big Data insight into the relationship between diet and health but is limited by a lack of individual granularity and heterogenous intra-borough populations. This research offers a starting point to further exploring in-depth food purchasing habits with healthcare outcomes, and further partnership in the future may unlock this.