The radius of maximum wind (RMW) is a crucial factor in typhoon wind simulation. Due to the spatial and regional characteristics of the typhoon process, there are few general theories or empirical equations for determining the RMW that satisfy all scenarios. This study aims to provide a general methodology for determining the optimal parameters for the RMW calculation. Based on the genetic algorithm (GA) and the Jelesnianski typhoon wind model, the GA-typhoon model was established. Four typhoon processes and four buoys in the southeast coastal areas of China were observed and analyzed. For each typhoon process, a group of parameters was obtained from the GA-typhoon model, which performed well when compared with other empirical models and observed data. Focusing on the southeast coastal areas of China, the four typhoon processes were employed to evaluate the characteristics. Then, the optimal parameters for RMW and the corresponding wind field models were provided. The Super Typhoon Lekima (#1909) was used to validate the optimal model in both wind and subsequent wave data. The results showed that the optimal model simulation results were consistent with the observed data and showed better performance than other widely used models.