MALT Type Research Articles

English

In Ethiopia, barley selection has focused on grain yield traits. Limited information is available on straw yield and its nutritive value. The aim of this study was to screen cultivars for grain and straw yield and nutritive value using forty cultivars of food and malt barley types at two locations in Ethiopia (Bekoji and Kofele) in 2018. Food-fodder quality traits investigated were crude protein (CP), neutral detergent fibre (NDF) and metabolizable energy (ME) of grain and straw. Location, cultivar and their interaction affected the performance in malt as well as food barley types. Wide cultivars differences were observed within food and malt types respectively: Grain CP: 10.2-12.2% and 11.4.1-13.3%, grain NDF: 40-2-52.7% and 38-42.9%, grain ME: 9.9-12.3 MJ/kg and 12.1-14.5 MJ/kg, straw CP: 4.1-5.7% and 4.9-6.2%, straw NDF: 73.5-76.7% and 72.9-76.1%, straw ME: 5-5.6 MJ/kg and 5.3-5.8 MJ/kg. Across locations, IBON174/03 produced most grain (6.95 t/ha), traveller produced most straw (9.1t/ha) and HB1963 was relatively high in both straw 8.4 t/ha and grain yield 6.4 t/ha, making it an interesting food-feed cultivar. Therefore IBON174/03, traveller and HB1963 are promising barley cultivars for the study area. Key words: Food-feed, cultivar, barley, straw.

Raoultella ornithinolytica in MALT-type non-Hodgkin Lymphoma.

Raoultella ornithinolytica is a bacterium that belongs to the Enterobacteriaceae family. The most frequently reported infections are gastrointestinal and hepatobiliary. Urinary tract infections are very rarely reported and bloodstream infections are usually reported without an identified source. This bacterium is responsible for an increasing number of infections, especially in immunocompromised patients. The authors describe the first case ever reported of an immunocompromised patient due to non-Hodgkin lymphoma MALT type and corticotherapy, who developed urinary tract infection and subsequently bacteriemia due to this pathogen.LEARNING POINTSRaoultella ornithinolytica is a virulent pathogen causing community-acquired and hospital-acquired infection, especially in immunocompromised populations.Although most cases of R. ornithinolytica infection are susceptible to standard antibiotic regimens, multi-drug resistant strains have been reported, which may pose a severe risk to the immunocompromised patient.Physicians should be aware that some treatments may increase immunosuppression, thus enabling infection by opportunistic agents such as R. ornithinolytica.

Comparative Study on Phenolic Content and Antioxidant Activity of Different Malt Types.

Malt is the main raw material for beer production, which determines not only its taste and aroma profile, but to a large extent its biological value, as well. The aim of the present research was to determine the antioxidant profile of different malt types as a basis for the development of new types of beer with increased antioxidant activity. In the present study the main brewing characteristics, the phenolic profile and the antioxidant potential of 20 malt types used in craft breweries in Bulgaria have been examined. The main brewing characteristics have been determined by the standardized methods of the European Brewing Convention. Malt phenolic content was determined by two methods, and antioxidant potential by five different methods. Based on a statistical factor analysis performed by the principal component analysis, it was confirmed that there was a relationship between malt color and phenolic compounds content. The principal component analysis confirmed that there was a link between the content of the Maillard reaction products and malt biological activity. Malts with the highest degree of heat treatment were characterized by the highest antioxidant activity, which was due to the content of Maillard reaction products with antioxidant capacity.

ИССЛЕДОВАНИЕ СОЛОДОВЕННЫХ СВОЙСТВ КАЗАХСТАНСКИХ СОРТОВ ЗЕРНА ТРИТИКАЛЕ ДЛЯ ИСПОЛЬЗОВАНИЯ В ИНДУСТРИИ НАПИТКОВ

Today the beverage industry occupies an important place in the processing industry of the Republic of Kazakhstan and is one of the most attractive investment sectors of the economy. However, this industry is still not provided in sufficient quantities with its own, domestic high-quality raw materials - rye and / or barley malt. For example, fermented malt is used as a source of colors and aromas. It is the main raw material in the preparation of kvass, kvass wort concentrate and kvass bread, the rate of application of this type of malt is from 40 to 60%, depending on the method of production of this type of product. The processing of cereals with a high protein content (above 12%) and a low starch content and extractiveness is economically disadvantageous, and undesirable from a quality point of view. The most important directions in solving this problem should be recognized as the improvement and development of new resource-saving technologies of malt using non-traditional types of raw materials. Currently, the use of triticale grain in the fermentation industry in the production of malt and the further replacement of traditional types of malt for the preparation of alcohol, beer, kvass is promising. In recent years, new varieties of triticale have been obtained in the Republic of Kazakhstan, which are distinguished by high technological properties, which are included in the State Register. In this regard, it is obvious that the performance of work related to theoretical and experimental research aimed at the development of new technological modes of preparation of malt from triticale is one of the urgent tasks, the decision of which, to create an assortment of drinks. The purpose of the research work is to study the malting properties of Kazakhstani varieties of triticale grain.

Comparison of chemical parameters of enzyme active and inactive malt types

Nowadays there is an increasing emphasis on the use of raw materials. Typically, raw materials – in this study malt – are used in animal feeds and used in the brewing industry. However, in terms of quality (eg. high fibre content), these can be included in human nutrition, we have limited information on this possibility. The aim of our work was to compare different malt flours and examine the possibility of using malt in the baking industry. We were to investigate some of the most relevant parameters, such as dietary fibre content, crude protein content, fat content, carbohydrate content, dry matter content, moisture content, salt and energy content. In the future, we aim to conduct a research on some of these parameters with different malt types as the brewing industry uses novel ingredients different cereals, pseudocereals such as amaranth (Amaranthus spp.), oat (Avena sativa L.), quinoa (Chenopodium quinoa Willd.) in addition to the spring barley (Hordeum vulgare L.) or wheat (Triticum aestivum L.). Based on brewing studies, malt has a high fibre and protein content. Having these advantageous qualities, malt should be part of humans’ healthy diet. Using malt flour in the baking industry can be a new direction which can lead to creating a healthier lifestyle and healthier eating habits than suggested by the WHO (World Health Organization).

A Case of Primary Burkitt Lymphoma of the Bladder

The most frequent primary lymphomas of the bladder are the low-grade B-cell- derived non-Hodgkin’s lymphomas of the MALT type, including Burkitt’s lymphoma. Primary genitourinary localization of lymphomas is uncommon and, in particular supra vesical development of Burkitt lymphoma. The continuous progress of treatment by chemotherapy has changed the pejorative prognosis of this disease into a good one.

Tumor Cell Microenvironment and Microvessel Density Analysis in MALT Type Lymphoma.

MALT type lymphoma belongs to marginal zone lymphoma (MZL). MALT lymphomas' inflammatory microenvironment contributes to the pathogenesis of this cancer. In this study, we analyzed and quantified the tumor inflammatory microenvironment in MALT lymphoma samples and in healthy controls, and the microvessel content by immunohistochemistry and morphometric estimation. Biopsy specimens from MALT type lymphoma patients and from non-metastatic axillary lymph nodes (CTRL) were analyzed by immunochemistry in order to quantify CD3, CD4, CD8, CD68, CD163, tryptase, CD34, and Ki67 positive cells. A substantial increase in the number of cells that were positive for the above markers and microvascular density (MVD) were observed in the MALT group. We also found a positive correlation between microvessels and CD8+ cells and between CD8+ cells and M2 type macrophages, while tryptase+ mast cells correlated with CD4+ cells. The mitotic proliferation index Ki67 was higher in MALT samples. The interactions between inflammatory cells in the tumor microenvironment and their correlation with angiogenesis is a useful tool in the development of new immunotherapy strategies.

Uncovering Patterns of Italian Consumers’ Interest for Gluten-Free Beers

This study explored the interest for Gluten-Free Beer (GFB) in a panel of beer drinkers. The authors adopted a conjoint rating experiment and the respondents were given sixty-four beer concepts to evaluate and score on a 9-point scale of interest. Each concept included eleven factors (alcohol content, colour, type of malt, beer price, drinking location, drinking occasion, bottle size, label claims, type of farming, type of brewer, and bottle closure) varied at different levels. The results showed that the consumers placed greatest importance on alcohol content (30.8%), followed by beer colour (18.3%), price (13.8%), type of brewer (9.5%), drinking occasion (9.5%) and bottle closure (6.5%). The label claim “rich in” and the factors drinking location, malt type, bottle size, and type of farming were judged as being of little importance. Average consumers’ interest for GFB was moderate (5.48 on a 9-point scale) and oriented towards a blond small-scale brewed beer with a %ABV > 7.0. This beer was priced in the 1.51-2.50 Euros range per 0.33 L bottle and was suitable for drinking in the evening after dinner. Differences in interest between genders, age classes, and patterns of beer consumption are reported and discussed. These results support new GFB development and ensure R&D processes are tailored to the target consumer.

Study of antioxidant activity and phenolic compounds of extracts obtained from different craft beer by-products

This work deals with the study of the in vitro antioxidant potential of aqueous extracts obtained from brewer's spent grain (BSG) and lees (BL) from four brewing craft beers. The effect of type of malt (base malts with different percentage of roasted malt (BSG1: 0%, BSG2: 7,2%, BSG3: 11,8% and BSG4: 16%) and hop added during brewing (BL1-3: boil hopping, BL4: boil and dry hopping)) on the antioxidant potential of extracts, was studied. Results for BSG showed that the higher the content in roasted malt, the lower DPPH, ABTS+ and TPC values were found in BSG extracts. Results for BL extracts showed that BL4 (boil and dry hopping) presented the highest TPC content. Gallic acid, 4-hydroxyphenil acetate, epicatechin and sinapic acid were the major compounds contributing to the total phenolic content in all BSG samples whereas large differences among groups were found regarding to these compounds for BL.

Improvement of the concentration and type of malt in flour-based food

This article presents studies of optimization of recipes and nutritional value of bakery products using six types of malt from cereals and legumes. Using the method of mathematical modeling, a reference sample, a blend was determined, and the formulation of multicomponent food - products buns and breads was optimized.

Breeding and brewing quality of the Canadian malting barley variety 'CDC Goldstar' lacking lipoxygenase-1.

Various types of malt quality profiles have been investigated to benefit the North American brewing industry. Herein, we report the development and brewing quality of the hulled, two-row malting barley (Hordeum vulgare L.) variety ‘CDC Goldstar’ lacking lipoxygenase-1 (LOX-1-less). This new variety offers a novel malt type for the improvement of beer flavor stability. The agronomic performance of ‘CDC Goldstar’ was tested in the Western Cooperative Two Row Barley Registration Trials during 2013–2014. In addition to high lodging tolerance, the new variety showed 6% higher yield than the current leading variety ‘CDC Copeland’. The malt quality of ‘CDC Goldstar’ showed higher diastatic power and lower wort β-glucan content than ‘CDC Copeland’ and controllable proteolytic modification (soluble nitrogen and Kolbach Index). Pilot- (100 L) and commercial-scale (5,000 L) brewing trials were conducted using ‘CDC PlatinumStar’, another LOX-1-less variety with a low enzymatic profile, as the control variety. Absence of the LOX-1 trait from ‘CDC Goldstar’ maintained trans-2-nonenal levels in aged beers as low as those in other LOX-1-less varieties without affecting major beer parameters, such as ester and aldehyde content or foam stability. The newly developed ‘CDC Goldstar’ malting barley provides added value for the beer industry and consumers.

Expression of germinal center cell markers by extranodal marginal zone lymphomas of MALT type within colonized follicles, a diagnostic pitfall with follicular lymphoma

We reviewed 341 consecutive cases of marginal zone lymphoma (MZL) (47) or follicular lymphoma (FL) (294) of which 7 were difficult to distinguish due to perceived coexpression of BCL6 and BCL2 by tumor cells in follicular foci. This stimulated us to develop dual BCL6/BCL2 immunohistochemistry, allowing us to assess coexpression among individual cells. Dual staining confirmed coexpression in 6 of 7 cases, all extranodal MZL (ENMZL) based on overall features and representing 13% of MZL in this series. These findings confirm that MZL cells have plasticity regarding protein expression within the germinal center (GC) microenvironment, an important diagnostic pitfall. Intriguingly, in all MZL expressing BCL6, non-neoplastic GC B cells within colonized follicles showed diminished or absent CD10 expression but preserved BCL6 and high ki67. This finding suggests plasticity of CD10 expression in non-neoplastic GC B cells in the context of colonization by MZL, possibly related to NF-kB dysregulation.

Effect of solid-state fermentation over the release of phenolic compounds from brewer's spent grain revealed by UPLC-MSE

Brewers' spent grain (BSG) is the major by-product of the brewing industry and presents a rich chemical composition as substrate for fermentation, besides a valuable source of bioactive compounds. Solid-state fermentation (SSF) was applied using five strains of filamentous fungi in different types of BSG to evaluate the release of phenolic compounds (PC) characterized by UPLC-ESI-QTOF-MSE. Aspergillus oryzae after 3 days of fermentation was the most effective in the release of antioxidant compounds based on Folin-Ciocalteu and DPPH results. Globally, a total of 102 compounds were tentatively identified. Ferulic, p-coumaric and caffeic acids were the most abundant PC in BSG. Metabolomic approach was essential to reveal distinct PC when SSF was applied to BSG, the ratio bound to free PC was strongly reduced, probably due to the release of compounds from the lignocellulosic matrix by the fungi β-glucosidase. The malt types also significantly impacted the fermentation behavior, resulting in different phenolic profiles. Unlike the number of identifications, the total abundance was 50% reduced after fermentation, probably due to the biotransformation/degradation of hydroxycinnamic acids into their derivatives. SSF effectively increased the release of bound PC leading to a more complex and distinguished profile according to type of malt.

Determination of Cytolytic Malt Modification – Part II: Impact on Wort Separation

The cytolytic malt criteria viscosity and β-glucan are used as an integral part of routine laboratory control measures to classify the malt modification level and to ensure good processability. Part one of this two-part publication demonstrated that barley varieties with high cytolytic modification along with low β-glucan content tend to have a higher content of usually unconsidered water-soluble arabinoxylan. This study investigated the arabinoxylan molar mass distribution and its impact on processability. In order to observe the impact of arabinoxylans on separation processes in the brewhouse, lautering tests of different modified malt types were performed. The results suggest that in contrast to their lower β-glucan content, highly modified malt types had a higher average arabinoxylan content (767 mg/L) than medium modified samples (710 mg/L). Furthermore, differentiation of arabinoxylan molar mass resulted in a higher molar mass of 14–34% above 50 kDa in these samples. In terms of processability, flux through the spent grain cake was mainly influenced by wort viscosity (r=-0.621, p < 0.01), although arabinoxylan had little influence on the viscosity. However, 53% of highly modified malt samples had a flux of less than 4 L/h × m2 (average value) despite low β-glucan levels. A principal component analysis identified arabinoxylans as the main driving force in connection with the permeability through the filter cake, whereby especially highly modified barley varieties (60%) were affected. Arabinoxylans may have a decisive effect, so it is not only β-glucan as a structural cell wall substance and present viscosity that should be considered as determining quality characteristics.

Caracterização físico-química de cervejas artesanais de atemoia (Annona cherimoia Mill. x Anonna squamosa L) e de sapoti (Manilkara sapota L.)

O objetivo deste estudo foi produzir cervejas artesanais com adição das frutas tropicais atemoia e sapoti em sua composição. Para elaboração dos mostos cervejeiros as matérias primas utilizadas foram malte tipo Pilsen e levedura cervejeira tipo Lager. A polpa de atemoia foi adicionada no mosto cervejeiro na concentração de 8,5% (p/v) e a polpa de sapoti na concentração de 17% (p/v). O processo de fermentação alcoólica ocorreu a 15ºC por 15 dias e o processo de maturação das cervejas verdes ocorreu a 5ºC por 15 dias. Após engarrafamento e carbonatação na própria garrafa realizaram-se as análises físico-químicas das três cervejas produzidas: cerveja sem adição de frutas (cerveja Pilsen), cerveja com polpa de atemoia (cerveja de atemoia) e cerveja com polpa de sapoti (cerveja de sapoti). A adição das polpas de frutas aumentou o teor alcoólico das cervejas de atemoia (5,0ºGL) e de sapoti (5,0ºGL) em relação à cerveja sem frutas (4,6ºGL). Também foi observado um aumento do teor de compostos fenólicos totais das cervejas de atemoia (111,29 mg/100 mL) e de sapoti (77,61 mg/100 mL) em relação à cerveja sem frutas (64,00 mg/100 mL). Outro resultado observado foi o aumento da atividade antioxidante das cervejas de atemoia e sapoti em relação à cerveja sem frutas. A utilização das polpas de atemoia e sapoti mostraram-se tecnologicamente viáveis na produção das cervejas artesanais. As cervejas com frutas valorizam o uso de frutas tropicais e despertam a atenção dos consumidores de cervejas artesanais.

Renewing Traditions: A Sensory and Chemical Characterisation of Mexican Pigmented Corn Beers.

This study was undertaken to explore how the use of pigmented corn as brewing ingredient influences the sensory profile of craft beers, by using both sensory and chemical analyses. Six pigmented corn and barley beers were brewed and then analysed to obtain their sensory characteristics, volatile composition and non-volatile (alcohol, bitterness, anthocyanins and polyphenol content) composition. ANOVAs, Principal Component Analysis (PCA) and Multiple Factor Analysis (MFA) were used to visualise these data for exploring the differences between beers based on the type of malt and to characterise corn beers considering the relationships between their sensory characteristics and their chemical parameters. The sensory attributes such as fermented fruits, cooked vegetables, tortillas, bread, dried fruits and dried chili characterised beers made 100% with pigmented corn. Over 100 volatiles were identified by head space-solid phase micro-extraction coupled with gas chromatography-mass spectrometry (HS-SPME/GC-MS). Among them, phenols and terpenes were the groups of volatiles that better characterised beers containing corn. The content of anthocyanins in corn beers provide the ‘amber-red-cooper’ colours in beers and may prevent the development of off-aromas and tastes. The use of pigmented corn seems to be a good option to renew the traditional ‘Sendechó’ while preserving some of its sensory attributes.

Phytochemical Composition of Brewers’ Spent Grains

Abstract Brewers’ spent grains (BSG) are the main waste product of the brewing industry, accounting for about 85% of the total waste materials. Their composition is different (due to various brewing technologies) but includes high levels of dietary fiber, proteins, essential amino acids, polyphenols, antioxidants, vitamins and fats. The aim of the present study was to investigate the phenolic content and antioxidant activity (the radical scavenging assay (DPPH) and ferric reducing antioxidant power (FRAP)) of 19 different malt types and their BSG. The highest phenolic content was demonstrated by the BSG of Caraaroma malt, whereas the BSG of Carafa Special type 1 had the highest DPPH radical scavenging activity and ferric reducing antioxidant power. Based on the results obtained, malts with the highest biological value were selected for inclusion in the composition of functional foods.

MON-441 Primary Thyroid Maltoma: A Rare Non-hodgkin Malignancy

Introduction: Thyroid lymphoma is a rare malignancy; only 2% of extranodal lymphomas arise within the thyroid gland. Furthermore, lymphomas represent no more than 2% of all malignant thyroid tumors and almost always non-Hodgkin type. Case: A 58-year-old female with a medical history of rheumatoid arthritis treated with Golimumab for years. Exam revealed a right thyroid lobe enlargement with bilateral palpable nodules. Labs include TSH of 1.4 mU/L, Free T4 of 1.76 ng/dL, normal anti-thyroid peroxidase antibodies, but elevated anti-thyroglobulin. US of the thyroid showed right-sided, hyperechoic nodule measuring 1.3cm, and left-sided solid hypoechoic nodule measuring 2.2cm. US-guided FNA of the right nodule yielded atypical cells of undetermined significance (2017 Bethesda category III). FNA of the left nodule showed severe, chronic thyroiditis, with small clonal population of cells and suspicion for lymphoma. She underwent total thyroidectomy with left central lymph node dissection. Microscopic evaluation showed a predominant lymphocytic population with plasmacytoid/plasma cells. The histological finding was consistent with extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT lymphoma or MALToma). However, thyroid tissues were negative for clonal immunoglobulin gene rearrangements (both immunoglobulin heavy and light chains). Immunohistochemistry demonstrated that the tumor cells were CD19, CD 20, CD 22, PAX5, CD78A positive, highlighting predominantly small to medium-sized B- cell lymphocytes, along with plasmacytoid/plasma cells (MUM1 and CD 75A positive). Furthermore, occasional reactive germinal centers (CD10, BCL6 positive, BCL2 negative) were noted. In conclusion, these features were consistent with a low grade, non-Hodgkin’s lymphoma of MALT type. Discussion: EMZL is a clinically indolent non-Hodgkin lymphoma, and growing evidence suggests that numerous cases originate in the background of chronic immune stimulation. MALToma is associated with Hashimoto’s thyroiditis or other immune diseases. Whereas half of EMZL can still arise without a Hashimoto thyroiditis background. Characteristics of the MALToma include reactive follicles, with the neoplastic cells invading the marginal zone (small lymphocytes, marginal zone B-cells, and plasma cells). The key findings are the presence of clonality (light chain restriction), and confirmation of B-cell origin (presence of B-cell markers). The immunophenotype is confirmed by immunohistochemistry and flow cytometry. Localized EMZL of the thyroid can be effectively treated with radiation alone. Surgery is usually used for diagnostic biopsy only. Chemotherapy is usually reserved for those with advanced stages

INFLUENCE OF MALT ON THE INTENSITY OF THE ENZYMATIC PROCESSES

Currently, it is relevant to use malt during the dough preparation. Malt is the catalyst of the fermentation process and, at the same time, is a natural flour improver. Bread, baked with the addition of enzyme-converted malt, becomes porous and gets a spicy taste. The purpose of the research is to study the influence of different types of malt on the intensity of the enzymatic processes of bakery. The main objectives of the study were to get various malt products, based on grain and bean raw materials, and to prepare them for the fermentation process, to determine the optimal concentrations of the sponge dough components, to examine the influence of the additional raw materials and to determine the duration of the fermentation process. While preparing the sponge flour, water, malt and yeast were added to all the samples, but leaven and pregelatinized flour were added only to the rye dough. Rye, triticale, wheat, pea, barley and soybean kinds of malt were used. The prepared samples of the dough were baked till 37% of moisture was obtained inside the crumb. The processes of fermentation of sponge dough, consisting of wheat flour with various malt additives, are described with polynomial and logarithmic equations with the reliability of R2 approximation from 0.9662 to 1. The best results were obtained while using wheat malt in the production of both wheat and rye bread. Peas and barley malt are slightly inferior to wheat one. The wheat bread, made with the use of rye malt, scored the smallest number of points. And when making rye bread, soy malt was less intense.

Güneydoğu Anadolu Bölgesindeki Non-Hodgkin Lenfoma Sınıflaması: 550 Hastanın İncelenmesi

Background: The distribution of non-Hodgkin lymphoma (NHL) subtypes differs around the world. In this study we aimed to evaluate the gender, age, subtypes, biopsy sites, nodal and extranodal residential area, and stage of disease in the patients with NHL admitted to our hospital between January 2005 and December 2014.Materials and Methods: The records of NHL patients admitted to our hospital between January 2005 and December 2014 were retrospectively reviewed Results: Among 550 patients, 335 patients (60.9%) were male, 215 patients (39.1%) were female. The average age of over all the patients was 56 years (15-95). The average age of women was 57 (15-88), the average age of men was 54 years (15-95). The histological subtypes of NHL patients were as follows: 447 patients (81.3%) B-cell lymphoma, 84 patients (15.2%) T / NK cell lymphoma, 19 patients (3.5%) unclassified subtype. NHL patients divided into subtypes according to 2001 and 2008 WHO (World Health Organization) Classification and histopathologic subtypes were as follow: Diffuse Large B Cell Lymphoma (DLBCL) 295 patients (53,63%), small lymphocytic lymphoma (SLL) 37 patients (6.7%), Extranodal marginal zone lymphoma (MALT type) 37 patients (6,75%), peripheral T-cell Lymphoma 27 patients (4.9%), mantle cell lymphoma 26 patients (4.72%), Nodal Marginal Zone B-Cell Lymphoma 7 patients (1,3%), follicular lymphoma in 12 patients (2.1%), Burkitt's lymphoma 7 patients (1.3%), Splenic marginal zone B-cell lymphoma 4 patients (0,7). The most common subtype of NHL was DLBCL 295 patients (53,63%). Follicular lymphomas are less common in our center. Extranodal involvement rate was 38,5% of patients. According to the distribution of the sites of extranodal NHLs, the vast majority of patients 43% had GI tract involvement. The most commonly affected GI sites were stomach (27,8%). In this study 22.9% of the patients were in Stage 1, 26.7% in Stage 2, 19.5% in Stage 3, 30.9% in Stage 4 according to Ann- Arbor classification. In conclusion, the characteristics of NHLs in our region show some differences from other sites of the world. Conclusions: The characteristics of NHL patients vary according to geographical differences. Present study has revealed the importance of geriatric assessment. NHL was observed frequently in men. Environmental risk factors have to research, epidemiologically. The most common subtype of NHL was DLBL. Follicular lymphomas are less common in our center. Improvement of national cancer registration system and multicenter large-scale studies reviewing the treatment protocols are needed to ensure the early diagnosis and therapy of NHL.