Insertion Type Research Articles

Thermohydraulic performance investigation of a heat exchanger with combined effect of ribbed insert and Therminol55/MXene+ Al2O3 nanofluid: A numerical two-phase approach

MXene-based nanofluids are novel trends with improved dispersion stability and thermophysical characteristics over previously established nanofluids. In the present work, the thermohydraulic characteristics of a double pipe heat exchanger (DPHEX) with a Therminol55(TH55)/MXene + Al2O3 nanofluid and various geometrically shaped (triangular, rectangular) ribbed twisted tape (TT) inserts are numerically investigated using the ANSYS Fluent interface. A counter flow arrangement with three different types of inserts (RRTT, TRTT, TT) and TH55/MXene + Al2O3 nanofluid at 0.20 wt% are studied inside the heat exchanger. Adding ribbed inserts to the conventional TT insert enhances the turbulence intensity by creating extra vortices. The thermal boundary layer grows thinner due to increased axial and radial velocity. Due to the substantial flow obstruction, adding ribs increases the overall pressure drop between the inlet and outlet. The maximum increase in Nu is 11.04 % using nanofluid instead of water, whereas the combination of insert and nanofluid exhibited up to 105 % enhancement for rectangular-ribbed TT compared to the plain tube. Nevertheless, the pressure decrease is found to be maximum in rectangular-ribbed TT because of significant flow disruption. This was likewise true with triangular-ribbed TT and TT insert. According to the PEC assessment, the RRTT insert had a maximum PEC value of 1.67 greater than TRTT and traditional TT for both TH55 and nanofluid flowing inside the tube. To summarize, the combination of TH55/MXene + Al2O3 RRTT insert may be a promising choice for improving heat exchanger performance in a new generation efficient thermal system.

What Sentence Repetition Tasks Can Reveal about the Processing Effort Associated with Different Types of Code-Switching

In this study, we explored the linguistic consolidation processes associated with bilingual processing using an experimental paradigm novel in bilingualism research, i.e., sentence repetition. We tested 46 L1-German L2-English bilinguals immersed in the L2 context. Firstly, we compared participants’ sentence repetition accuracy in single-language sentences and in sentences involving code-switches. Secondly, we investigated the processing cost associated with different types of code-switching, i.e., alternation, insertion, and dense code-switching. Finally, we assessed the following potential predictors of repetition accuracy: regular usage of different code-switching types, executive functions (working memory and inhibitory control), as well as relevant bilingualism variables (proficiency, dominance, and immersion). Our first finding was that bilinguals displayed reduced repetition accuracy in sentences involving code-switches compared to single-language sentences, but only when the single-language sentences were in the participants’ L1. This suggests that any processing costs associated with code-switching are modulated by bilinguals’ language background. Moreover, bilinguals’ poor performance in L2 compared to L1 single-language sentences, despite reporting high levels of L2 exposure frequency, highlights the importance of age of acquisition and dominance profiles for language processing. In terms of code-switching, our results revealed that bilinguals’ repetition accuracy differed across different types of code-switching. The processing effort associated with different types of code-switching in the sentence repetition task was primarily driven by the structural depth and the degree of mixing of the involved code-switch, i.e., dense forms of code-switching involving high levels of linguistic co-activation were harder to repeat than alternations involving unintegrated language switching. This effect partially converged with bilinguals’ sociolinguistic practices because bilinguals also reported lower exposure frequency to dense code-switching, but no direct correlations were observed at the level of individual differences. In terms of general cognitive functions, repetition accuracy was modulated by working memory but not by inhibitory control. By investigating this issue, we hope to contribute to our understanding of language processing in the face of cross-linguistic consolidation processes.

ANALISIS KEGAGALAN GEOMETRI KOMPONEN BRACKET HINGE CAB PADA PROSES BORING DIMESIN CNC MILLING OKK VC51

The Boring Process of Hinge Cab Bracket components is one of the machining processes at PT. MMI.Boring work is the process of enlarging the hole to the desired size and usually pays less attention togeometric deviations from the results of the boring process, even though it greatly affects the quality of themachining results. In general, a spherical profile is said to be perfectly round if the distance of the pointscontained in the geometric shape have the same distance from a point called the center point. The purpose ofthe study was to determine the effect of spindle speed and feeding speed on the geometric size of the barcketcomponent. The method used in this research is an engineering study with experiments and data collection iscarried out through field observations and analysis of ongoing programs. The independent variable in thisstudy was 0.1 mm infeed depth, with spindle rotation parameters of 400 rpm, 500 rpm, 600 rpm, 700 rpmand 800 rpm. The dependent variable is the geometric deviation of the Bracket Hinge Cab boring results.The control variable is the insert type TNMG332-GN LC5010 which has a feed speed (fz) of 0.1 mm/rev anda roughing size of 104 ±0.30, coolant damin water and ecocool 2700T. The measurement method uses a boregauge/cylinder gauge to determine the effect of variations in machining parameters on the geometry of theboring results with a tolerance of ± 0.30 mm and takes 4 axes of measurement, namely X, Y, X', Y'. From theresearch that has been done that the parameter with the smallest geometric deviation is obtained in the fourparts with a spindle rotation (n) 700 rpm, which is the expected result because the geometric deviation is70μm, still within the tolerance limit of ± 0.30 mm and has a roughness level of 9.278 Ra. The greater thevalue of the cutting speed (Vc), the smaller the geometric deviation that occurs. To get good results based onthe analysis and for results that are in accordance with the standard, the best Rpm is used at 700 rpm withFeeding 140 mm/minute.

Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration

The prime editor (PE) can edit genomes with almost any intended changes, including all 12 possible types of base substitutions, small insertions and deletions, and their combinations, without the requirement for double strand breaks or exogenous donor templates. PE demonstrates the possibility of correcting a variety of disease-causing mutations and might expand the therapeutic application of gene editing. In this study, PE was optimized based on a dual-adeno-associated virus (AAV) split-intein system in vitro by screening different split sites and split inteins. We found that splitting PE before amino acid 1105(Ser) of SpCas9 with Rma intein resulted in the highest on-target editing. The orientations of pegRNA and nicking sgRNA in the AAV vector were further optimized. To test the in vivo performance of the optimized dual-AAV split-PE3, it was delivered by subretinal injection in rd12 mice with inherited retinal disease Leber congenital amaurosis. The prime editors corrected the pathogenic mutation with up to 16% efficiency in a precise way, with no detectable off-target edits, restored RPE65 expression, rescued retinal and visual function, and preserved photoceptors. Our findings establish a framework for the preclinical development of PE and motivate further testing of PE for the treatment of inherited retinal diseases caused by various mutations.

THE USE OF CODE-MIXING IN INSTAGRAM CAPTIONS FROM THE STUDENTS OF ENGLISH LITERATURE STUDY PROGRAM, UNIVERSITAS RESPATI YOGYAKARTA: A SOCIOLINGUISTIC STUDY

This research discusses the code mixing used in the Instagram caption by students English Literature Study Program at Universitas Respati Yogyakarta. This research aims to find the types of code mixing used in Instagram captions and to understand the factors using code mixing in captions. The focus analysis of this research is by analyzing the context. This research was conducted by implementing a descriptive qualitative method in discussing code-mixing. A simple quantitative method is implemented to assist the qualitative method in explaining the data in the form of numbers or percentages. The findings of this research show that there are 70 code-mixing data found in Instagram captions. The analysis findings show that there are three types of code mixing found in Instagram captions. Those are code-mixing insertion, alternation and congruent lexicalization. From the results of the analysis in this research, the type of insertion is the type that is the highest or most commonly found, that is 54 data (59.1%). Then alternation type with 12 data (17.1%), and congruent lexicalization type with 4 data (5.71%). and for the results of the second question in this research, there are 60 data (85.71%) for the first factor talking about a particular topic, the second factor is being emphatic about something with 4 data (5.71%), the third factor is repetition used for clarification with 4 data (5.71%) and 2 data (4, 28) for the expressing group identity.

Development of a Scaffold-on-a-Chip Platform to Evaluate Cell Infiltration and Osteogenesis on the 3D-Printed Scaffold for Bone Regeneration.

Developing a scaffold for efficient and functional bone regeneration remains challenging. To accomplish this goal, a "scaffold-on-a-chip" device was developed as a platform to aid with the evaluation process. The device mimics a microenvironment experienced by a transplanted bone scaffold. The device contains a circular space at the center for scaffold insert and microfluidic channel that encloses the space. Such a design allows for monitoring of cell behavior at the blood-scaffold interphase. MC3T3-E1 cells were cultured with three different types of scaffold inserts to test its capability as an evaluation platform. Cellular behaviors, including migration, morphology, and osteogenesis with each scaffold, were analyzed through fluorescence images of live/dead assay and immunocytochemistry. Cellular behaviors, such as migration, morphology, and osteogenesis, were evaluated. The results revealed that our platform could effectively evaluate the osteoconductivity and osteoinductivity of scaffolds with various properties. In conclusion, our proposed platform is expected to replace current in vivo animal models as a highly relevant in vitro platform and can contribute to the fundamental study of bone regeneration.

Anatomical variations of the flexor carpi ulnaris in the fetal period

Introduction: The Flexor Carpi Ulnaris (FCU) is a part of the palmar the forearm muscle group and one of the most important muscles for upper limb functioning - is responsible for flexion and adduc­tion of the hand at the radio-carpal joint. There are clinically significant but rare anatomical variations of FCU. The variability of the FCU has not been described up to now, and no typology of the muscle based on its more variable terminal attachment has been created. Aim of the study: Determination of FCU muscle typology based on available fetal material. Material and methods: A total of 114 human fetuses (53 female, 61 male) between 117 and 197 days of fetal life were eligible for the study. Preparations were carried out using classical anatomical techniques based on a previously published procedure. Thanks to that significant anthropometric landmarks were vis­ible for the gathering of metric measurements. Metric measurements were taken and statistically analysed using R-Project software. Results: A new typology was created based on variable muscle insertions. Additionally, the presence of an atypically located, additional, separated muscle belly was described. A comparison of measurements of the left upper limb in relation to the right upper limb showed significant differences for forearm length to the anthropometric point of the stylion radiale, limb length, total FCU length and FCU length which means that the left limb is longer than the right limb. A comparison of FCU insertion types between left and right upper limb showed there’s no significant difference between counts of each type. Conclusion: The FCU is a muscle that is easy to palpate and may therefore act as a topographical marker for healthcare professionals. Knowledge of its variability is not only of theoretical importance but also has clinical sig­nificance. The current publication demonstrates presence of variability in FCU terminal attachment. Certainly, this topic requires further research and continued work on a detailed understanding of forearm anatomy in the fetal period.

Complications in Laparoscopic Access in Standing Horses Using Cannula and Trocar Units Developed for Human Medicine.

First cannulation is a critical manoeuvre in equine laparoscopy. This retrospective study aimed at the comparison of the frequency and type of complications detected when using different human laparoscopy devices for laparoscopic access in standing horses, and the influence of body condition in such complications. Forty-four procedures were included, and retrieved data comprised cannula insertion technique, body condition, and type and frequency of complications. Laparoscopic access techniques were classified into five groups: P: pneumoperitoneum created using Veress needle prior to cannulation; T: sharp trocar; D: direct access via surgical incision; V: Visiport optical trocar and H: optical helical cannula (OHC). In groups T, D, V and H, access was achieved without prior induction of pneumoperitoneum. Complications were registered in 13/44 procedures, of which retroperitoneal insufflation was the most common (6/13). Statistically significant association was found between the complication incidence and the type of access, with group D showing the highest complication frequency (80%) and group H the lowest frequency (0%). The majority of complications (9/13) were observed in overweight horses. We conclude that devices designed for human patients can be used for laparoscopic access in standing horses, with the use of OHC minimizing the appearance of complications, especially in overweight horses with OW.

Unstable Total Hip Arthroplasty: Should It Be Revised Using Dual Mobility Implants? A Retrospective Analysis from the R.I.P.O. Registry.

Total hip arthroplasty (THA) is one of the most common surgical procedures in orthopedics; however, it is subjected to different kinds of failures, one of them being dislocation. Many different prosthetic designs have been developed to overcome this problem, such as dual mobility coupling. The main purpose of this article is to determine whether there are differences regarding the revision surgery of unstable THA comparing the risk of failure between dual mobility cup (DMC) implants, standard implants, and among different head sizes. A registry-based population study has been conducted by analyzing data collected by the Emilia Romagna Registry of Orthopedic Prosthetic Implants (RIPO), including a total of 253 implants failed for dislocation and instability that were operated on by cup revision surgery between 2000 and 2019. The selected population has been divided into two groups based on the insert type: standard and DMC. The age at revision surgery was significantly lower in the standard cup group with respect to DMC (p = 0.014 t-test), with an average age of 71.2 years (33-96 years range) for the standard cups and 74.8 years (48-92 years range) for the DMC group. The cumulative survival of DMC implants was 82.0% at 5-years, decreasing to 77.5% at a 10-year follow-up, which is not significantly different from standard cups (p = 0.676, Log-Rank test). DMC implants showed a significantly lower risk of re-revision for dislocation compared to standard cups (p = 0.049). Femoral heads ≥36 mm had a higher overall survival compared to smaller femoral heads (p = 0.030). This study demonstrated that DMC or femoral heads ≥36 mm are a valid choice to manage THA instability and to reduce the revision rate for dislocation at a mid-term follow-up; in those selected and targeted patients, these options should be taken into consideration because they are associated with better outcomes.

Obrada struganjem kaljenih čelika alatima od PcBN

The paper discusses the results of the experimental investigation of the performance of several grades of PcBN cutting composites in conditions of the interrupted machining of hardened steel. Both BH and BL types of PcBN indexable inserts with additions of Si3N4, TiC, and TiCN were tested, and cutting speed varied to assess the possibility of applying these cutting tools in different conditions. It has been shown that BL PcBN can be utilized for turning with shock loads in case of high cutting speed and low depth of cut (0,2 mm). While in the range of comparatively low cutting speeds BL cutting tools are actually inoperable, and because of microchipping of polycrystalline fragments and brittle destruction of the cutting edge, an increase of the cutting speed to 210 m/min changes wear pattern and formation of the wear land. As well as this, measurement of the form and values of the cutting forces impulses revealed the effect of their peak growth by up to 40%. The danger of shock impulses was analyzed by FEM modeling, and it was demonstrated that during impacts, the maximal value of the third Principal stress exceeds the average level of compressive stresses during continuous cutting by 1.6 times, which can cause damage to the cutting tool. The data on the estimation of tool fracture probability depending on loading conditions are presented, and the possibility of reducing such probability is shown.

An Overview of Best Practices for Transposable Element Identification, Classification, and Annotation in Eukaryotic Genomes.

Transposable elements (TEs) exert an increasingly diverse spectrum of influences on eukaryotic genome structure, function, and evolution. A deluge of genomic, transcriptomic, and proteomic data provides the foundation for turning essentially any non-model eukaryotic species into an emerging model to study any and all aspects of organismal biology, ultimately shaping future directions for biomedical, environmental, and biodiversity research. However, identification and annotation of the mobile genome component still lags behind the standards accepted for host gene annotation. To achieve the objective of providing every genome project with a comprehensive description of its mobilome component in addition to the standard genic and transcriptomic datasets, each step of TE identification, classification, and annotation should be focused on improving TE boundary designation, reducing identification error rates, and providing accurate information on the type and integrity of TE insertions. Here, we offer practical advice for generating TE models in de novo assemblies for non-model organisms, provide step-by-step instructions to guide inexperienced TE annotators through some of the commonly utilized TE analysis pipelines, and entertain suggestions for tool improvement which could be implemented by interested developers.

Multiple errors correction for position-limited DNA sequences with GC balance and no homopolymer for DNA-based data storage.

Deoxyribonucleic acid (DNA) is an attractive medium for long-term digital data storage due to its extremely high storage density, low maintenance cost and longevity. However, during the process of synthesis, amplification and sequencing of DNA sequences with homopolymers of large run-length, three different types of errors, namely, insertion, deletion and substitution errors frequently occur. Meanwhile, DNA sequences with large imbalances between GC and AT content exhibit high dropout rates and are prone to errors. These limitations severely hinder the widespread use of DNA-based data storage. In order to reduce and correct these errors in DNA storage, this paper proposes a novel coding schema called DNA-LC, which converts binary sequences into DNA base sequences that satisfy both the GC balance and run-length constraints. Furthermore, our coding mode is able to detect and correct multiple errors with a higher error correction capability than the other methods targeting single error correction within a single strand. The decoding algorithm has been implemented in practice. Simulation results indicate that our proposed coding scheme can offer outstanding error protection to DNA sequences. The source code is freely accessible at https://github.com/XiayangLi2301/DNA.

P065Long acting reversible contraceptive (larc) insertions in 2019 in the states with most restrictive and trigger abortion policies

<h3>Objectives</h3> As of May 2022, 26 states have been identified as certain or almost certain to ban abortion should the 1973 Roe decision recognizing women's constitutional right to choose to terminate be overturned. The purpose of this analysis was to describe the rate of insertions of long-acting reversible contraceptives (LARCs), the most effective forms of contraception, in those 26 states. <h3>Methods</h3> Data was from a HealthVerity Marketplace claims data source representing 130 million patients, representing 58% of the US census population. Women aged 15–44 were included in the analysis. For each healthcare encounter, the following data were gathered: three-digit zip code, age, implant insertion (y/n), intrauterine device (IUD) insertion (y/n), provider specialty, and payer type (Medicaid or commercial). LARC insertion rates by three-digit zip code geographic areas in the 26 states with pending abortion bans were described. <h3>Results</h3> In four states with pending abortion bans, LARC insertion rates were consistently low: <2.6% in either all or nearly all three-digit zip code areas. Four states had consistently top quartile LARC insertion rates (>4.1%). The remaining states had wide variation in LARC insertion rates; some three-digit zip code areas fell in the lowest quartile of insertions (<2.6%) and other areas showing highest percentiles of LARC insertions (>4.1%) <h3>Conclusions</h3> Use of LARCs vary among the geographic areas within the states with certain or near-certain abortion trigger bans. These variations in LARC insertion rates may indicate significant additional reproductive health burdens for women who may already be facing significant restrictions on their reproductive health choices.

The expression of Ets-1 and Fli-1 is associated with interferon-inducible genes in peripheral blood mononuclear cells from Japanese patients with systemic lupus erythematosus.

Transcription factors E26 transformation-specific-1 (Ets-1) and Friend leukemia insertion site-1 (Fli-1) and type I interferon (IFN) have been implicated in systemic lupus erythematosus (SLE). We examined the expression of these genes in peripheral blood mononuclear cells (PBMCs) from Japanese patients with SLE and analyzed their association with SLE. We enrolled 53 Japanese patients with SLE, 42 patients with rheumatoid arthritis (RA), and 30 healthy donors (HDs) (as controls) in this study. PBMCs were collected from all participants, and the expressions of Ets-1, Fli-1, and three interferon-inducible genes (IFIGs) (interferon-inducible protein with tetratricopeptide 1 [IFIT1], interferon-inducible protein 44 [IFI44], and eukaryotic translation initiation factor 2 alpha kinase 2 [EIF2AK2]) were measured using real-time polymerase chain reaction (PCR). The relationships of each molecule with clinical symptoms, laboratory data, and treatments were analyzed. The expression of Ets-1 and Fli-1 was significantly lower in the PBMCs from patients with SLE than that in the PBMCs from patients with RA and HDs. The expression of the three IFIGs was significantly higher in the PBMCs from patients with SLE than that in the PBMCs from patients with RA and HDs. For patients with SLE, significantly positive correlations were found between Ets-1 and three IFIGs; a similar trend was observed between Fli-1 and IFIGs. IFIG expression in the PBMCs was significantly higher in patients with SLE than that in other participants, and the expression of Ets-1 and Fli-1 was positively associated with IFN expression. Therefore, it was suggested that Ets-1 and Fli-1 were associated with the pathophysiology of SLE by regulating the type I IFN pathway.

Numerical investigation on thermal-hydraulic performance of air preheater equipped with helical inserts

In the present work, a numerical study has been done for the air preheater equipped with different types of helical inserts inside the tubes with segmental baffles in shell. The simulations have been carried out to analyse the heat transfer rate in terms of heat transfer coefficient and friction factor with ANSYS 18.0. The air preheater is divided into two sections shell side and tube side, which contains ambient air and flue gases respectively. The air preheater consists of 34 tubes with a length of 3 m. In the present study, three different types of inserts are investigated with a pitch to diameter ratio (p/d) of 2, 1.7 and 1.4, and the number of turns of 100, 87 and 73, respectively. The insert under study is helical shaped with circular cross-section of diameter 20 mm. Four different values of Reynolds number are used in the range of 4000–24,000. The effects of pressure drop, heat transfer coefficient on different pitch to diameter ratio (p/d) 2, 1.7 and 1.4 of inserts and on the plain tube are discussed in this present work. The results of an air preheater with inserts in tubes get higher value of heat transfer coefficient as compared to the plain tubes. The thermal performance factor of air preheater with inserts of (p/d = 1.4) shows higher factor of 2.31 as compared to the plain tubes at low Reynolds number.

Novel hybrid neuro-fuzzy model to anticipate the heat transfer in a heat exchanger equipped with a new type of self-rotating tube insert.

In this investigation, a combination of the wingsuit flying search (WFS) and teaching-learning-based optimization (TLBO) algorithms is developed as a new combinatorial optimization algorithm. The proposed combinatorial algorithm is tested over some well-known benchmark functions and then integrated with the artificial neural network (ANN) to construct a novel hybrid model. After that, the obtained hybrid model is employed to anticipate the experimentally obtained values of the average Nusselt number (Nu), average friction coefficient (f) as well as thermal-hydraulic performance ratio (η), in a heat exchanger equipped with a new type of self-rotating tube insert, against governing parameters. The insert is placed in the tube side of the water heater to heat natural gas. The proposed insert consists of various numbers of self-rotating modules. Indeed, the rotating insert is introduced to create effective secondary sweeping flow on the inner side of the tube. Since this type of tube insert simultaneously provides heat transfer enhancement and undesired pressure drop, a thermal-hydraulic performance ratio is defined to consider both of them. The governing parameters are the number of inserts (0≤N≤30), reservoir's temperature (40 °C ≤ TR≤50 °C) as well as Reynolds number (6 × 103≤Re≤18 × 103). It was found that the WFS-TLBO enhances the effectiveness of the main ANN in anticipating the Nusselt number (Nu), average friction coefficient (f) as well as performance ratio (η). Moreover, introducing the WFS-TLBO algorithm into the neural network provides an enhancement in the effectiveness of the hybrid models based on the single WFS and TLBO algorithms in anticipating the same parameters.

Zero-Strain Insertion Anode Material of Lithium-Ion Batteries.

The insertion type materials are the most important anode materials for lithium-ion batteries, but their insufficient capacity is the bottleneck of practical application. Here, LiAl5 O8 nanowires with high theoretical capacity and Li-ions diffusion coefficient are prepared and studied as an insertion anode material, which exhibits zero-strain properties upon electrochemical cycling. However, the poor electronic conductivity of LiAl5 O8 definitely sacrifices the capacity and limits the rate performance. Therefore, compact LiAl5 O8 and carbon composite are further synthesized, in which nanosized LiAl5 O8 particles are uniformly embedded in an amorphous carbon matrix. It displays a reversible capacity of 490.9 mAh g-1 at 1 A g-1 , and the capacity rises continuously to 996.8 mAh g-1 after 1000 cycles due to the interfacial storage mechanism, that the excess Li+ ions can be accommodated in the grain boundaries and C/LiAl5 O8 interfaces.

Heat Generation During Initial Osteotomy for Implant Site Preparation: An In Vitro Measurement Study

IntroductionControlling temperature generation during implant site preparation is important to prevent implant early failure.AimThe present in vitro study aimed at measuring temperature variation generated during the initial osteotomy using both rotatory and piezo-surgical inserts.MethodsNine groups were defined according to drill and insert type, cooling volume (mL/min) and cooling temperature. A total of 315 implant site preparations were performed in an artificial bone sample and the temperature was measured using an infrared camera. Drills’ wear was assessed using scanning electron microscopy at baseline and after 10 and 35 utilizations.ResultsPiezo-surgical insert groups determined a temperature increase that was significantly higher than the one generated by rotatory drills groups (p < 0.001). When considering rotatory drills groups a temperature ≥ 40 °C was never recorded.ConclusionLower saline temperature implied a significant temperature decrease (p < 0.001), while the increase in cooling volume did not imply a temperature decrease. The scanning electron microscopy analysis of the drills demonstrated that little drill wear occurred up to 35 utilization times.

Variant pectoralis minor muscle: a case study with clinical relevance.

The pectoralis minor (PMn) muscle originates from the third, fourth, and fifth ribs near the costochondral junctionusually and gets inserted on the medial margin and upper surface of the coracoid process of the scapula. To look at the morphological insertion patterns and sites of attachment of the PMn muscle in the donated cadavers. Over all 19 limbs were included in the study (9 right and 10 left). Out of 19 limbs, 10 belonged to female and 9 belonged to male cadavers. The cadavers were meticulously dissected to determine the morphological insertion types and location of the attachment of the muscle. Unusual pattern of insertion was observed in 6 limbs (31.6%) out of total 19 limbs included in the study. The variations we observed does not fall completely in the classification by Le Double, hence variations we observed can be considered as new and rare variant which to our knowledge is not reported in literature. We propose this new variant to be type 4 of Le Double classification. The potential of ectopic PMn tendon should be taken into consideration and tested out, especially in patients with shoulder discomfort and stiffening who have ruled out the more frequent diseases. For proper surgical planning, a preoperative magnetic resonance imaging or USG examination of the shoulder joint is required considering the prevalence of variation in the insertion pattern of PMn muscle. Preoperative identification of any abnormal PMn insertion can help to reduce the risk of iatrogenic tendon injury and post-operative problems.

Simple quality assurance based on filtered back projection for geometrical/irradiation accuracy in single-isocenter multiple-target stereotactic radiotherapy.

In single-isocenter multiple-target stereotactic radiotherapy (SIMT-SRT), it is difficult to evaluate both the geometrical accuracy and absorbed dose measurement when irradiating off-isocenter targets. This study aimed to develop a simple quality assurance (QA) method to evaluate off-isocenter irradiation position accuracy in SIMT-SRT and compare its feasibility with that of a commercial device. First, we created two types of inserts and metallic balls with a diameter of 5mm to be inserted into a commercially available phantom (SIMT phantom). Second, we developed a dedicated analysis software using Python for the Winston-Lutz test (WLT). Third, an image processing software, including the filtered back-projection algorithm, was developed to analyze the images obtained using an electronic portal imaging device (EPID). Fourth, the feasibility of our method was evaluated by comparing it with the results of WLT using two commercially available phantoms: WL-QA and MultiMet-WL cubes. Notably, 92% of the results in one-dimensional deviations were within 0.26mm (EPID pixel width). The correlation coefficients were 0.52, 0.92, and 0.96 in the left-right, superior-inferior, and anterior-posterior directions, respectively. In the WLT, a maximum two-dimensional deviation of 0.70mm was detected in our method, while the deviation in the other method was within 0.5mm. The advantage of our method is that it can evaluate the geometrical accuracy at any gantry angle during dynamic rotation irradiation using a filtered back-projection algorithm, even if the target is located off the isocenter. Our method can perform WLT at arbitrary positions and is suitable for the QA of dynamic rotation irradiation using an EPID.