Popularity of wearing maximum cushioned (MC) shoes by long-distance runners has increased over the last several years, primarily for the purpose of injury prevention and reduced stress. While maximum cushioning on the heels and midsoles can provide maximum shock absorption, the added weight of the shoes could negatively affect running economy. Previous research on the effects of various footwear types on energy expenditure has yielded conflicting results. PURPOSE: to determine the differences in energy expenditure among MC and standard (ST) footwear types. METHODS: Sixteen runners (8M/8F; age = 27.90 ± 13.13 years; weight = 71.2 3± 10.14 kg; height = 174.7 ± 6.51 cm) participated in the study. In a single data collection session, the participant was asked to complete three 6-minute running trials on a treadmill at a self-selected pace, under different footwear conditions. Footwear conditions included MC shoes (HOKA Conquest), ST shoes (New Balance Running Course), and ST shoes with the weight matched to the MC shoes (ST-W). A minimum of a 4-minute break was given between trials, and the order of the footwear conditions was randomized. For each running trial, oxygen consumption (VO2), heart rate (HR), energy expenditure (kcal), and rating of perceived exertion (RPE) were measured. Repeated measures ANOVA was used for each dependent variable (α=0.05). RESULTS: Overall, there was no difference among shoe conditions for any of the dependent variables. No difference in the average HR was observed among footwear conditions (MC= 161 ± 14.6, ST= 163 ± 11.9, ST-W= 162 ± 12.7 bpm; p>0.05). There was no difference among footwear conditions on average VO2 (MC= 42.7 ± 4.89, ST= 42.6 ± 5.30, ST-W= 42.9 ± 5.39 ml/kg/min; p>0.05) or energy expenditure (MC= 15.3 ± 3.21, ST= 15.3 ± 3.28, ST-W= 15.4 ± 3.34 kcal/min; p>0.05). Similarly, no difference in the RPE was observed among footwear conditions (MC= 12.5 ± 1.46, ST= 12.3 ± 1.40, ST-W= 12.5 ± 1.41; p>0.05). CONCLUSION: Additional weight of the MC shoes or adding weight to the ST shoes did not change energy expenditure and other physiologic measures, as compared with the ST shoe condition, during a 6-minute run. Mechanical benefits of the MC shoes are unknown, however the maximum cushioning did not seem to affect running economics.