Purpose Literature on eco-innovation brings insights that help to understand which factors trigger innovation focused on sustainability in companies. However, when analyzing the studies that comprise such drivers, it appears that most of them were focused only on describing them in isolation. Therefore, this study aims to understand which are the combinations of drivers that favor the adoption of eco-innovation in slaughterhouses located in the Brazilian state of Rio Grande do Sul. Design/methodology/approach This study has used the crisp-set qualitative comparative analysis (csQCA) as the data analysis technique, in addition to the previous application of Most Similar Different Outcome/Most Different Same Outcome (MSDO/MDSO). Findings This study identified eight internal and external drivers that explain the differences in performance of eco-innovative and non-innovative slaughterhouses. These drivers generate 13 combinations of factors capable of favoring the adoption of five types of eco-innovation. Research limitations/implications A limitation identified was the difficulty to obtain information held by companies on environmental issues. In addition, in each company the authors only approached one respondent. Practical implications The use of combinations is identified by companies and governmental and non-governmental organizations to promote eco-innovation in slaughterhouses. Originality/value This study may be considered original for its contribution to the improvement of eco-innovation literature by describing how the drivers identified combine to favor the adoption of certain types of eco-innovation. In addition, the authors also made an original use of csQCA, linked with MSDO/MDSO, in the field of eco-innovation.