Failure analysis and fatigue life prediction are important steps in the design procedure of industrial products to assure the safety and reliability of their components. A new methodology to predict the fatigue life of a rubber mount based on the continuum damage mechanics is proposed in this study. The hyperelastic constitutive model of the natural rubber material in the mount was fitted using the three parameter Mooney-Rivlin model. A damage variable was introduced and the evolution function of cumulative damage in the rubber material was derived. The parameters in the damage function were acquired based on uniaxial tensile tests and fatigue life tests of the natural rubber specimens. Then the finite element analysis (FEA) models of the rubber mount for loads in the X and Y directions were established and the strain contours and the maximum principal strains of the rubber mount under various loads were calculated. The maximum principal strain was used as the fatigue parameter, which was substituted into the natural rubber’s fatigue life damage function to predict the fatigue life of the rubber mount. Finally, the fatigue lives of the rubber mount under various loads were measured on a fatigue test rig to validate the accuracy of the fatigue life prediction method. The test results indicated that the fatigue lives predicted agreed fairly well with the test results and the fatigue prediction method should be applicable to both rubber and other types of components.