Gel Type Research Articles

Development of modular extrusion bioprinter prototype

Introduction: The aim of this work was to develop a prototype of a modular extrusion bioprinter capable of performing 2D and 3D printing with hydrogels based on sodium alginate and gelatin. Materials and methods: The bioprinter uses Cartesian coordinate system, the print head is movable in Y and Z axes, the printing platform is in X axis and equipped with cooling system. Constructs were printed with 3 types of gels: based on gelatin with the addition various concentrations of xanthan gum; based on combination of gelatin and sodium alginate; based on gelatin and xanthan gum with the addition of carbon nanotubes. Results: The constructs from various gels corresponded to the structure determined by their digital models. Conclusions: The developed system allows performing 2D and 3D printing with gels based on gelatin, sodium alginate, including those containing carbon nanotubes and/or xanthan gum for a wide range of experimental tasks.

Investigation on preparation and properties of gel type 188W/188Re generator

As one of the most important integrated nuclides for diagnosis and treatment in recent years, rhenium-188 (188Re) has a broad scope in the clinical application. Due to the specific properties of such radionuclide, it was mainly provided by the chromatographic 188W-188Re generators. There is no doubt that the application of 188Re in the treatment of various diseases depended on the development of 188W-188Re generator. Considering the high standards of such technology on radioactive activity of 188W and impurity content, a 188W-188Re generator filled with the zirconium tungstate gel has been prepared in this work. The effects of molar ratio of chemical agents, pH, reaction temperature, drying methods, rinsing methods and other conditions on the synthesis of gel particles have been studied. Furthermore, a variety of characterization techniques were used to observe the macro-/micro-morphology and chemical structure of gel particles. It can be concluded that vacuum freeze-dried method could significantly increase the specific surface area, pore size and tungsten content of gel particle. In order to decrease the content of 188W in the elute, a handful of acidic alumina was filled in the bottom of our 188W-188Re generator, an elution and purification integrated-generator was formed. During the first five processes, the nuclear purity of 188Re solution was above 99.99%, the radiochemical purity was approximately 99.5%, the pH value was 5.0–7.0 and the average elution efficiency reached up to 82.7%. In addition, the leakage rate of 188W was low as 1.60 × 10−6, and the peak of elute curve was located at 2 mL without the trailing phenomenon. This work lays a solid foundation for the domestic demand of daughter nuclide 188Re, further makes an outstanding contribution to the application of the radiation therapy technology and the protection of people's health.

Research on Efficient Electromagnetic Shielding Performance and Modulation Mechanism of Aero/Organo/Hydrogels with Gravity-Induced Asymmetric Gradient Structure.

To eliminate electromagnetic pollution, it is a challenging task to develop highly efficient electromagnetic shielding materials that integrate microwave absorption (MA) performance with high shielding capability and achieve tunability in shielding performance. Asymmetrically structured aero/organo/hydrogels with a progressively changing concentration gradient of liquid metal nanoparticles (LMNPs), induced by gravity, are prepared by integrating the conductive fillers Ti3C2Tx MXene and LMNPs into a dual-network structure composed of polyvinyl alcohol and cellulose nanofibers. Benefiting from the unique structure, which facilitates the absorption-reflection-reabsorption process of electromagnetic waves along with conductive fillers and the porous structure, three types of gels demonstrate efficient shielding performance. HPCML achieves a total shielding effectiveness (SET) of up to 86.9dB and a reflection shielding effectiveness (SER) of as low as 2.85dB. Especially, APCML, with an ultra-low reflection coefficient (R) of 6.4%, achieves compatibility between shielding performance and MA properties. The relationship between dispersing media (air, water, and glycerol/water) and the shielding performance of aero/organo/hydrogels is explored, thereby achieving modulation of the shielding performance of the gel system. The work has paved a clear path for integrating absorption and shielding capabilities into a composite material, thereby providing a prototype of a highly efficient shielding material with MA performance.

Multifunctional tri-electrode sensors for the measurement of displacement, force, and infrared irradiation

Abstract Here we described the effect of displacement, force and infrared irradiation on the resistance and impedance of tri-electrode multifunctional sensors. These sensors are based on the gel type composite of carbon nanotubes (CNT), nickel phthalocyanine (NiPc) and edible oil. The channel of this tri-electrodes (field effect transistors) structure is made of CNT-NiPc-oil gel composite using rubbing-in technology. The tri-electrode sensors’ response depends upon the direction of force/displacement and shows an anisotropy. Application of force or displacement from the top causes to decrease resistance and the impedance and vice versa in case of applying force or displacement from the side. The displacement and force sensitivities were up to -273.3 Ω/µm and -46.5 Ω/gf from the top and 480.0 Ω/µm and 3.1 x 102 Ω/gf from the side, respectively, for the sensing ranges 0-150 µm and 0-215 gf. Under the effect of the infrared irradiation from any direction the impedance and the resistance of the sensor reduces. On changing infrared irradiation intensity from 0 to 2500 W/m2 the sensitivities from top and side of the sensor were -37.4 Ωm2/W and -16.5 Ωm2/W, respectively. The investigated sensors may potentially be used as prototypes to develop gel-electronic-based shockproof sensors. The technological achievement in fabricating these devices is the consumption of environmentally friendly materials, particularly edible oil (organic). The edible oil allows to formulate uniform composite gel-films, that may not be comprehended only by ingredients mixing. The fabricated sensors are highly attractive for commercialization.

Multimodal Pilot Evaluation of a Hyaluronic Acid Infraorbital Filler Using Precise, Multi-Positional, 3D Imaging Quantification, Patient Reported Outcomes, and Anatomic Cadaveric Assessments

Abstract Background Despite the high demand of filler in the infraorbital area, there remains debate on injection practices, precise anatomical placement, and hyaluronic acid (HA) filler behavior. Objectives We aimed to contribute to the clinical and anatomic understanding of infraorbital HA injection via a prospective patient injection study in combination with a cadaveric analysis. Methods Patients were injected with Volbella XC into the tear trough region by a single experienced aesthetic plastic surgeon. Over a 90-day period, precise undereye volumetric measurements using 3D photogrammetry (VECTRA-M3) and patient reported outcomes (FACE-Q) were collected and analyzed relative to two pretreatment severity scales. Juvéderm Vycross and Restylane NASHA products were injected into the infraorbital and malar region in six cephalus specimens and evaluated with regards to the anatomic injection location with and without common clinical physical manipulations. Results Eleven patients participated with a 100% retention rate. Infraorbital HA volume maintenance was 70-81% at 30 days and 50-70% at 90 days. Significant improvement was noted in the eyes, overall facial appearance, and cheekbones (p<0.05) with FACE-Q outcomes, irrespective of pretreatment severity. In the cadaver examination, we observed differences in the anatomic locations occupied by Juvéderm and Restylane products as well as in behavior after physical manipulation between gel types. Conclusions Volbella XC effectively augments undereye volume to diminish infraorbital hollowing as measured over a 90-day period with significantly improved PROs. Enhanced knowledge of the behavior of Volbella XC and other HA fillers in this sensitive anatomic region will lead to improved patient outcomes.

Enhancing photovoltaic cell design with multilayer sequential neural networks: A study on neodymium-doped ZnO nanoparticles

Multilayer sequential neural networks, a powerful machine learning model, demonstrate the ability to learn intricate relationships between input features and desired outputs. This study focuses on employing such models to design photovoltaic cells. Specifically, neodymium (Nd)-doped ZnO nanoparticles (NPs) were utilized as a photoanode for fabricating dye-sensitized solar cells (DSSCs). A natural dye extracted from Spinacia oleracea was employed, while two types of electrolytes, liquid and gel (polyethylene glycol-based), were used for comparative analysis. Extensive material characterization of the photoanode highlights the impact of Nd content on the physicochemical properties of ZnO. Notably, when the doped photoanode and gel electrolyte were combined, a substantial 110% improvement in power conversion efficiency (PCE) was achieved. Building on these findings, the machine learning model in this research accurately predicts the current-voltage (I-V) curve values for such photoanodes, with an impressive accuracy of 98%. Additionally, the model illuminates the significance of variables like crystal distortion, texture coefficient, and doping concentration, underscoring their importance in the context of photovoltaic cell design.

Development and Performance Evaluation of a New Conformance Control Agent Gel.

How to effectively plug the multi-scale fractured water channeling has always been the key to achieving efficient water flooding of fractured low-permeability oil reservoirs. In this paper, a new type of supramolecular-polymer composite gel is developed, which is suitable for plugging multi-scale fractured water channeling. The supramolecular-polymer composite gel is composed of a polymer (such as polyacrylamide), cross-linking agent (such as polyethyleneimine), supramolecular gel factor (such as cyclodextrin) and polarity regulator (such as ethyl alcohol). The mass fraction of polyacrylamide, polyethyleneimine, cyclodextrin and ethyl alcohol are 0.15%, 0.2%, 1% and 0.2%, respectively. At the initial state, the viscosity of the composite gelant system is less than 20 mPa·s. It has good injection performance in micro-scale fractures and can enter the deep part of a fractured reservoir. At 40 °C, the composite gelant system can form a gel with a double network structure after gelation. One of the networks is formed by the covalent interaction between polyacrylamide and polyethyleneimine, the other network is formed by the self-assembly of cyclodextrins under the action of the ethyl alcohol. The comprehensive performance of the composite gel is greatly improved. The strength of the composite gel is >5 × 104 mPa·s, and it has good plugging strength in large-scale fractures. The composite gel can be used as a conformance control agent for fractured low-permeability oilfields.

Systematic screening and evaluation for an optimal adsorbent in a facade-integrated adsorption-based solar cooling system for high-rise buildings

Solar-powered adsorption chillers are a climate-friendly solution for building cooling, but costs and space requirements limit their widespread adoption. Recently developed adsorption cooling facade systems (ACFS) save installation space and further reduce CO2 emissions. The performance of ACFS depends on the implemented adsorbent. To achieve low costs and high performance of ACFS, this study systematically screened and scored adsorbents using the analytic hierarchy process (AHP) method, focusing on price, stability, driving temperature and adsorption capacity. This method narrowed down 293 adsorbents to top 10 scored adsorbents including 4 silica gels, 4 active carbons and 2 molecular sieves. The adsorbent-specific performance is evaluated by numerical simulation, revealing silica gel Type A++, Type 2560, Siogel and molecular sieve AQSOA-FAM-Z02 have peak adsorber temperatures 1.5–9.3 °C lower and increase solar cooling efficiency (SCE) by 25–27 % compared to reference adsorbent Zeolite 13X. A sensitivity analysis of the Dubinin-Astakhov equation shows increasing E and decreasing V leads to an only minor adsorber temperature decrease and minor system efficiency increase. Lower temperatures and higher capacity cannot guarantee better system performance. This underscores that improving system performance cannot be achieved solely through adsorbent optimization but requires system optimization in parallel.

Μagnet integrated fabric phase sorptive extraction (MI-FPSE) for the selective isolation of seven sulfonamides from human urine prior to HPLC-DAD analysis

In the present study magnet integrated fabric phase sorptive extraction (MI-FPSE) was employed for the selective extraction of seven sulfonamides (i.e., sulfamerazine, sulfamethazine, sulfamethoxypyridazine, sulfamonomethoxine, sulfamethoxazole, sulfisoxazole and sulfadimethoxine) from human urine prior to their determination by high pressure liquid chromatography – diode array detection (HPLC-DAD). The MI-FPSE protocol was optimized after studying the critical parameters that affect extraction, namely: type of sol–gel sorbent, extraction time, desorption time, stirring rate, type and volume of elution solvent, the ionic strength and the pH of the sample matrix using the one-factor-at-a-time method. The developed MI-FPSE-HPLC-DAD method was validated in terms of linearity, sensitivity, selectivity, accuracy, and precision and presented satisfactory results. The limits of detection (LODs) and quantification (LOQs) ranged between 0.02–0.04 ng/μL and 0.06–0.15 ng/μL, respectively. The RSD% values of the intra-day and inter-day assays were found lower than 6.7 % and 9.4 %, respectively, showing good precision. Accuracy was assessed using percentage of relative recovery and varied from 86.3–112.9 % (intra-day study) and 85.5–106.9 % (inter-day study) for all examined analytes. The green character and practicality of the proposed method were investigated using the ComplexGAPI index and Blue Applicability Grade Index (BAGI).

Preparation and Characterization of Preformed Polyelectrolyte and Polyampholyte Gel Particles for Plugging of High-Permeability Porous Media.

Excessive reservoir water poses significant challenges in the oil and gas industry by diminishing hydrocarbon recovery efficiency and generating environmental and economic complications. Conventional polymer flooding techniques, although beneficial, often prove inadequate under conditions of elevated temperature and salinity, highlighting the need for more resilient materials. In this research, two types of acrylamide-based preformed particle gels (PPGs) were synthesized, as follows: polyelectrolyte and polyampholyte. These PPGs were engineered to improve plugging efficiency and endure extreme reservoir environments. The polyelectrolyte gels were synthesized using acrylamide (AAm) and sodium acrylate (SA), while the polyampholyte gels incorporated AAm, AMPS, and APTAC, with crosslinking achieved through MBAA. The swelling properties, modulated by temperature, salinity, and pH, were evaluated using the Ritger-Peppas and Yavari-Azizian models. The mechanical characteristics and surface morphology of the gels were analyzed using SEM and BET techniques. In sand pack experiments designed to mimic high-permeability reservoirs, the inclusion of 0.5 wt.% of fine PPGs substantially reduced water permeability, outperforming traditional hydrogels. Notably, the polyampholyte PPGs demonstrated superior resilience and efficacy in plugging. However, the experiments were limited by the low test temperature (25 °C) and brine salinity (26.6 g/L). Future investigations will aim to apply these PPGs in high-temperature, fractured carbonate reservoirs.

An oil-in-gel type of organohydrogel loaded with methylprednisolone for the treatment of secondary injuries following spinal cord traumas

The secondary injuries following traumatic spinal cord injury (SCI) is a multiphasic and complex process that is difficult to treat. Although methylprednisolone (MP) is the only available pharmacological regime for SCI treatment, its efficacy remains controversial due to its very narrow therapeutic time window and safety concerns associated with high dosage. In this study, we have developed an oil-in-gel type of organohydrogel (OHG) in which the binary oleic-water phases coexist, for the local delivery of MP. This new OHG is fabricated by a glycol chitosan/oxidized hyaluronic acid hydrophilic network that is uniformly embedded with a biocompatible oil phase, and it can be effectively loaded with MP or other hydrophobic compounds. In addition to spatiotemporally control MP release, this biodegradable OHG also provides a brain tissue-mimicking scaffold that can promote tissue regeneration. OHG remarkably decreases the therapeutic dose of MP in animals and extends its treatment course over 21 d, thereby timely manipulating microglia/macrophages and their associated with signaling molecules to restore immune homeostasis, leading to a long-term functional improvement in a complete transection SCI rat model. Thus, this OHG represents a new type of gel for clinical treatment of secondary injuries in SCI.

Food Protein Nanofibril Gels: From Conditions, Types and Properties to Applications.

Many food proteins can be assembled into nanofibrils under pH conditions far from the isoelectric point and with a low ionic strength by heating them for a long period. These food protein nanofibrils (FPN) have outstanding functional and biological properties and are considered sustainable biomaterials in many fields. In this study, we review the recent developments in FPN gels and introduce the key factors in promoting food protein self-assembly in order to create functional gels. The major variables discussed are the morphology of nanofibrils, protein concentration, heating time, and the type and concentration of salts. We also highlight current advances in the formation and properties of different types of FPN gels. In addition, the various applications of FPN gels in bioactive and nutrient delivery, adsorbents for CO2 and toxic pollutants, cell scaffolding biomaterials, biosensors, and others are introduced and discussed.

Experimental Evaluation of Performance of a Low-Initial-Viscosity Gel Flooding System.

In order to effectively adjust reservoir heterogeneity and further exploit the remaining oil, a new type of low-viscosity gel was prepared by adding a regulating agent, retarder, and reinforcing agent on the basis of a polymer + Cr3+ crosslinking system. The new gel has the advantages of low initial viscosity, a slow gel formation rate, and high strength after gel formation. The effectiveness of the gel was verified through three-layer core displacement experiments, and the injection scheme was optimized by changing the slug combination of the polymer and the gel. The results showed that the gel can effectively block the high-permeability layer and adjust reservoir heterogeneity. An injection of 0.1 pore volume (PV) low-initial-viscosity gel can improve oil recovery by 5.10%. By changing the slug combination of the gel and polymer, oil recovery was further increased by 3.12% when using an injection of 0.07 PV low-initial-viscosity gel +0.2 PV high-concentration polymer +0.05 PV low-initial-viscosity gel +0.5 PV high-concentration polymer.

Mechanical properties of low calcium alkali activated binder system under ambient curing conditions

These days, the construction industry is facing sustainability issues, leading to the selection of greener, low-carbon, alkali-activated materials. This study examines a low calcium alkali activated system composed of three constituents (ceramic brick, metakaolin waste, and phosphogypsum). The AAB compositions consist of the primary precursor, waste ceramic brick, which is increasingly (20–100 wt%) replaced with waste metakaolin. The alkaline solution was made of sodium hydroxide and water; dosage depended on the Na2O/Al2O3 ratio (1.00–1.36). The AAB specimens were inspected by using XRD (X-ray diffraction) and FT-IR (Fourier transform infrared spectroscopy) methods for the evaluation of mineral composition, accompanied by SEM–EDS (scanning electron microscopy & energy dispersive X-ray spectroscopy) for the analysis of the microstructure. The compressive strength after 7, 28 and 90 days, along with water absorption and softening coefficient were determined. Also, mixture calorimetry was established. The results have shown that the initial materials are suitable for producing medium-strength alkali-activated binder under ambient temperature. The maximum compressive strength was reached by using the combination of 80% CBW and 20% MKW (13.9 and 21.2 MPa after 28 and 90 days respectively). The compressive strength development was linked with the formation N–A–S–H gel and faujasite type zeolite. A higher level of geopolymerization in composition with metakaolin waste led to lower compressive strength. Consequently, binding materials with low demand of high final and especially early compressive strength could be produced under ambient temperature curing, making them more sustainable.

Preparation and Experimental Research of Temperature Sensitive Expansion Gel Material for Fire Prevention and Extinguishing in Coal Mines

ABSTRACT In order to solve the problems of high viscosity at room temperature, easy dehydration and shrinkage of phase change gel, and poor plugging effect of traditional mine gel, a new type of temperature-sensitive expansion gel was developed by using hydroxypropyl methyl cellulose, chitosan, guar gum and sodium bicarbonate as raw materials, using orthogonal test and response surface analysis. The structural characterization, characteristics, fire prevention, and extinguishing performance of the temperature-sensitive expansion gel were tested. The experimental results show that the optimal ratio of temperature-sensitive swelling gel is 0.75 wt % chitosan, 0.5 wt % acetic acid, 2.5 wt % hydroxypropyl methyl cellulose, 0.4 wt % sodium bicarbonate, and 0.15 wt % guar gum. The phase transition temperature (LCST) of this ratio is 67°C. After standing at room temperature for 6 h, the gel viscosity is 5852 mpa·s, the expansion ratio is 0.846, and the strength is 319.525 N/m2. During the heating process of the coal sample after adding the temperature-sensitive expansion gel, the gel will undergo phase change and expansion in the high-temperature area of the coal, and the viscosity will increase. It can stay in the high-temperature area, wrap the coal block, and isolate the oxygen from entering, thus effectively inhibiting the coal spontaneous combustion process. In addition, the gel also produces inert gas carbon dioxide, which effectively suffocates the flame. Therefore, compared with the conventional inhibitor solution, the temperature-sensitive expansion gel has better fire extinguishing effect.

Growth of Romaine Lettuce in Eggshell Powder Mixed Alginate Hydrogel in an Aeroponic System for Water Conservation and Vitamin C Biofortification.

Vitamin C is crucial for physical well-being, and its deficiency can lead to severe health consequences. Biofortification has been used to address this deficiency by enhancing vitamin C in plants. Additionally, soilless agriculture has been used to conserve and optimize water use in comparison to conventional agriculture. While hydrogels have been shown to improve water conservation and are used for biofortification in crops, their application has only been explored in soil-based and hydroponic farming. The aeroponics system is a plant-growing method that has shown potential for increasing yields and biomass while conserving water and nutrients. In this paper, we have developed an aeroponic-compatible medium to grow romaine lettuce (Lactuca sativa L.) with eggshell powder (ESP) mixed with calcium-alginate hydrogel as a substrate and nutrient source aiming to conserve water and incorporate vitamin C through biofortification. Herein, lower water spray time and higher intervals, with varied gel types and ESP concentrations, resulted in healthy lettuce growth. Plants treated with 0.5% ascorbic acid-absorbed ESP-mixed alginate hydrogel for biofortification showed higher levels of vitamin C compared to the traditional method. This study suggests using an alginate hydrogel-ESP-based substrate in aeroponics to reduce water usage and enhance plant biofortification of vitamin C.

Fabrication and Application of Grinding Wheels with Soft and Hard Composite Structures for Silicon Carbide Substrate Precision Processing.

In silicon carbide processing, the surface and subsurface damage caused by fixed abrasive grinding significantly affects the allowance of the next polishing process. A novel grinding wheel with a soft and hard composite structure was fabricated for the ultra-precision processing of SiC substrates, and the grinding performance of the grinding wheel was assessed in this study. Different types of gels, heating temperatures, and composition ratios were used to fabricate the grinding wheel. The grinding performance of the grinding wheel was investigated based on the surface integrity and subsurface damage of SiC substrates. The results showed that the grinding wheel with a soft and hard composite structure was successfully fabricated using freeze-dried gel with a heating temperature of 110 °C, and the component ratio of resin to gel was 4:6. A smooth SiC substrate surface with almost no cracks was obtained after processing with the grinding wheel. The abrasive exposure height was controlled by manipulating the type and ratio of the gel. Furthermore, the cutting depth in nanoscale could be achieved by controlling the abrasive exposure height. Therefore, the fabrication and application of the grinding wheels with soft and hard composite structures is important for the ultra-precision processing of large-size SiC substrates.

Chondroitin Sulfate/Hyaluronic Acid-Blended Hydrogels Suppress Chondrocyte Inflammation under Pro-Inflammatory Conditions.

Osteoarthritis is characterized by enzymatic breakdown of the articular cartilage via the disruption of chondrocyte homeostasis, ultimately resulting in the destruction of the articular surface. Decades of research have highlighted the importance of inflammation in osteoarthritis progression, with inflammatory cytokines shifting resident chondrocytes into a pro-catabolic state. Inflammation can result in poor outcomes for cells implanted for cartilage regeneration. Therefore, a method to promote the growth of new cartilage and protect the implanted cells from the pro-inflammatory cytokines found in the joint space is required. In this study, we fabricate two gel types: polymer network hydrogels composed of chondroitin sulfate and hyaluronic acid, glycosaminoglycans (GAGs) known for their anti-inflammatory and prochondrogenic activity, and interpenetrating networks of GAGs and collagen I. Compared to a collagen-only hydrogel, which does not provide an anti-inflammatory stimulus, chondrocytes in GAG hydrogels result in reduced production of pro-inflammatory cytokines and enzymes as well as preservation of collagen II and aggrecan expression. Overall, GAG-based hydrogels have the potential to promote cartilage regeneration under pro-inflammatory conditions. Further, the data have implications for the use of GAGs to generally support tissue engineering in pro-inflammatory environments.

Sliced Jelly Whole Swallowing Reduces Deglutition Risk: A Novel Feeding Method for Patients with Dysphagia.

Texture modification in the form of gels or jellies is used for patients with dysphagia. For over 20 years, our group has been using gelatin jellies, a type of gel, as a starting diet for patients with dysphagia. Gelatin jellies are served in a small-sliced form and swallowed whole. In sliced jelly whole swallowing (SJWS), sliced gelatin jelly (SGJ) passes through the pharynx in one lump without collapsing. This study aimed to examine the usefulness of SJWS. We analyzed the images of videofluoroscopic swallowing studies performed using the normalized residue ratio scale (NRRSv: vallecula, NRRSp: pyriform sinus), the penetration-aspiration scale (PAS), and pharyngeal transit time (PTT) in 50 patients with dysphagia and compared the results in a prospective study. SJWS had significantly less residue in both NRRSv and NRRSp than in moderately thickened liquid swallowing. No significant differences in PAS scores were found between SGJ and moderately thickened liquid. Additionally, no significant differences in PTT scores were noted between the two. This study demonstrated the usefulness of SJWS in improving swallowing safety in patients with dysphagia. Further studies are needed to evaluate the reproducibility of the test, the comparison of SGJ with other thickened liquids, and the safety of SJWS for different diseases.

Feasibility of using building-related construction and demolition waste-derived geopolymer for subgrade soil stabilization

A high-value utilization approach is essential to improve the utilization rate of building-related construction and demolition waste (brCDW). This study developed a novel approach by synthesizing a brCDW-derived geopolymer to stabilize high liquid limit subgrade soil. The unconfined compressive strength (UCS) test, shear strength test, resilient modulus test, and permanent strain test were conducted to investigate the effects of brCDW-derived geopolymer dosage, curing time, stress state, and moisture condition on the engineering properties of geopolymer stabilized soil. These test results demonstrated that increasing the geopolymer dosage effectively improved the UCS, shear strength and resilient modulus of stabilized soil and reduced the permanent strain of stabilized soil. The 8% brCDW-derived geopolymer provided adequate UCS, shear strength, resilient modulus, and resistance to permanent strain for stabilized soil, which showed the most economical improvement. Mechanistic-empirical models were employed to accurately estimate the stress-dependent resilient modulus and permanent strain of geopolymer stabilized soil at any given stress state. The Scanning Electron Microscope (SEM) and Energy Dispersive X-ray Spectroscopy (EDS) test were performed to investigate the strengthening mechanism of brCDW-derived geopolymer stabilization of subgrade soil. The SEM test results indicated that the porosity of stabilized soil was significantly decreased when the geopolymer dosage increased to 8%. The EDS test results demonstrated that the predominant gel types generated from the geopolymer stabilization might be Calcium–Aluminum-Silicate-Hydrate (C-A-S-H), Calcium-Silicate-Hydrate (C–S–H), and Calcium-Aluminate-Hydrate (C-A-H) gels. There was also a small amount of Sodium-Alumino-Silicate-Hydrate (N-A-S-H) gel detected in the geopolymer stabilized soil. Finally, the sustainability of brCDW-derived geopolymer stabilization approach was assessed in terms of material production cost, carbon dioxide emission, and energy consumption. The brCDW-derived geopolymer was proven as a sustainable stabilizer for subgrade soil.