Types Of Cargo Research Articles

ІНТЕГРОВАНЕ ПРОЄКТУВАННЯ ХВОСТОВОЇ ЧАСТИНИ ФЮЗЕЛЯЖУ ЛІТАКІВ ТРАНСПОРТНОЇ КАТЕГОРІЇ

For the first time, when designing transport category aircraft with a tail cargo hatch, a method of integrated design and construction of the fuselage tail section has been developed and presented, which, using mathematically described parameters, allows the creation of a particular master geometry of the fuselage tail section for a specifically selected cargo door scheme. The method has been improved to allow the design of transport aircraft not only at the stage of creating a fundamentally new aircraft concept, but also as a means of modifying an existing passenger aircraft type through deep modernization. A systematization and classification of existing types of cargo doors of the transport category aircrafts according to their design features has been developed. A separate group of tail cargo doors has been identified. Five typical schemes of cargo hatches in the tail section of the fuselage have been formed. A universal parametric method for specifying the master geometry of the fuselage tail section has been created, which allows the implementation of any of the above schemes of cargo doors in the fuselage tail section, including a unique one, implemented only on AN aircraft with a rolling ramp. The relationship between the parameters of the cargo door and the transportation characteristics of the aircraft, which depend on the range and types of cargo to be transported, methods of loading and unloading, and airdropung, is described. The methods of three-dimensional parametric modeling of both the tail sections of the fuselage and transport aircraft as a whole were further developed when creating a master geometry, a space distribution model, analytical standards of airframe structural elements, and a model for the complete determination of the geometric parameters of the aircraft using CAD/CAM/CAE/PLM technologies. The presented results have been implemented in the practice of designing transport category aircraft at ANTONOV Company, as well as at the National Aerospace University named after M.E. Zhukovsky “Kharkiv Aviation Institute” in the educational process of training aviation specialists.

Combating Antimicrobial Resistance by Resensitising Bacteria to Antibiotics Using CRISPR: A Narrative Review

Background: Antimicrobial resistance (AMR) remains a formidable global health threat. Conventional strategy of developing new antibiotics is costly and unsustainable. Thus, innovative approaches for resensitising bacteria using clustered regularly inter-spaced short palindromic repeats (CRISPR) technology are sought. Aims and Objectives: The aim of this study was to review existing technologies and approaches with the aim to identify the most feasible and practical approach to solve AMR globally. Methods: It is a narrative review of CRISPR research to identify a practical medical solution for combating AMR. By considering biological, social and pharmaceutical factors, feasible solutions and their limitations were identified. Next, CRISPR solutions were examined, then filtered based on strict medical expectations. A suitable cargo type and delivery mechanism will be established. Finally, the feasibility from a practical and economic perspective is considered. Results: Among the Cas effector modules examined, Cas12k was identified as the most promising candidate. Notably, Cas12k possesses a small protein size and lacks trans-cleavage activity, enhancing its specificity for targeted bacterial strains. Additionally, its naturally inactivated endonuclease domain further contributes to its precision. In line with this investigation, DNA plasmid was identified as the optimal cargo storage, while lipid nanoparticles were identified as the optimal delivery method. Conclusion: This is the first time an end-to-end consideration to AMR was considered for CRISPR-based strategies. This review offers valuable insights into a promising solution to addressing the AMR crisis. Such knowledge is essential to guide the development of novel AMR solutions.

Identifying possible ways for adapting an open wagon for transporting containers

The object of this study is the processes of perception and redistribution of loads in the supporting structure of a open wagon loaded with containers, taking into account the new scheme of their fastening. For safe transportation of containers in an open wagon, it is suggested to use a removable module. This module works according to the principle of an intermediate adapter between the container and the open wagon body. Fastening of the module itself in the open wagon is carried out through the fitting stops, which are placed on the floor of the open wagon. Mathematical modeling was carried out to determine the longitudinal dynamic load acting on the container fixed according to the new scheme in the open wagon. To this end, a mathematical model was built that characterizes the longitudinal movements of the "open wagon - removable module - container" system. Determination of the accelerations that act on the supporting structure of the open wagon loaded with containers was also carried out by means of computer simulation. Verification of the formed model of the dynamic load of the open wagon was carried out according to the F-criterion. Also, as part of the study, a modal analysis of the load-bearing structure of a open wagon loaded with containers was carried out, which made it possible to assess its traffic safety. A feature of the results obtained as part of the research is that the proposed design of the removable module could be used not only for fastening containers but also for transportation of other types of cargo. The field of practical application of the results is railroad transport, including other transportation industries. The conditions for the practical use of the results are a symmetrical scheme of loading the body of a open wagon with containers. The results of this study will contribute to increasing the efficiency of container transportation and the profitability of railroad transport

Mechanisms of extracellular vesicle uptake and implications for the design of cancer therapeutics.

The translation of pre-clinical anti-cancer therapies to regulatory approval has been promising, but slower than hoped. While innovative and effective treatments continue to achieve or seek approval, setbacks are often attributed to a lack of efficacy, failure to achieve clinical endpoints, and dose-limiting toxicities. Successful efforts have been characterized by the development of therapeutics designed to specifically deliver optimal and effective dosing to tumour cells while minimizing off-target toxicity. Much effort has been devoted to the rational design and application of synthetic nanoparticles to serve as targeted therapeutic delivery vehicles. Several challenges to the successful application of this modality as delivery vehicles include the induction of a protracted immune response that results in their rapid systemic clearance, manufacturing cost, lack of stability, and their biocompatibility. Extracellular vesicles (EVs) are a heterogeneous class of endogenous biologically produced lipid bilayer nanoparticles that mediate intercellular communication by carrying bioactive macromolecules capable of modifying cellular phenotypes to local and distant cells. By genetic, chemical, or metabolic methods, extracellular vesicles (EVs) can be engineered to display targeting moieties on their surface while transporting specific cargo to modulate pathological processes following uptake by target cell populations. This review will survey the types of EVs, their composition and cargoes, strategies employed to increase their targeting, uptake, and cargo release, and their potential as targeted anti-cancer therapeutic delivery vehicles.

Abstract B046: Enhanced immune cell engineering utilizing a novel, effective intracellular delivery method for introduction of diverse cargo types

Abstract Engineered immune cell therapies have great potential to revolutionize cancer therapeutics and progress has been made in developing both engineering and manufacturing methodologies. However, limitations remain in some areas including long manufacturing times, potential for cell exhaustion, and limited access to the disease site as in the case for solid tumors. In addition, some immune cell types such as monocytes, B cells, and gamma delta T cells have remained difficult to engineer.Portal has developed a novel implementation of mechanoporation technology using a silicon membrane with pores which enables deformation of the cell and poration of the cell membrane, allowing for diffusion of any cargo, charged or uncharged, into the cell. Mechanoporation is a gentle intracellular delivery technique which preserves cell viability and function in cells (DiTommaso, et al PNAS 2018) and has the potential to shorten manufacturing time as well as allow for introduction of key therapy enhancing factors via transient modifications shortly before therapy administration. Portal has established methodology for cytoplasmic introduction of many diverse cargo including mRNA, circular RNA, siRNA, proteins, peptides, and CRISPR RNPs to primary immune cells, including both unstimulated and activated T cells, B cells, NK cells, monocytes and iPSCs. The Portal technology is easily scalable, enabling both research scale (1e6 - 5e7 cells) and process scale (over 1e9 cells) deliveries. Editing and RNA expression efficiencies are above 80% with viability maintained at 70% or above. We have demonstrated sustained expression of circular RNA, and have successfully delivered an mRNA CAR. Cargo can easily be multiplexed with equivalent delivery efficiencies across cargo classes. Portal’s methodology is gentle and effective enough to be utilized multiple times within a therapeutic workflow. For example, we have demonstrated high editing efficiencies in unstimulated T cells, followed by rapid expansion for 7 days and subsequent mRNA delivery at clinical scale - yielding over 50% knockout and 90% mRNA expression. Portal’s technology and approach has the potential to further advance immune cell therapy developments, particularly in multiplexed engineering approaches involving simultaneous delivery of multiple cargos. Coupled with Portal’s compatibility with diverse immune cell types and next generation cargos, such as circRNA, we believe this simple approach to intracellular delivery can dramatically reduce manufacturing time and cost, easily integrate into existing clinical equipment and enable unique enhancements that underpin a new generation of therapeutics. Citation Format: Zhihui Song, Eleni Rogers, Sophia Hirsch, Andrew Larocque, Darby Kreienberg, Rachel Conover, Jacquelyn Hanson, Alec Barclay, Mathias Pawlak, Armon Sharei. Enhanced immune cell engineering utilizing a novel, effective intracellular delivery method for introduction of diverse cargo types [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy; 2024 Oct 18-21; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2024;12(10 Suppl):Abstract nr B046.

Investigation of some issues of automation of elements of terminal complexes for transshipment of large-capacity containers

The topic of the work is the study of the reasons for increasing the efficiency of the use of marine container transportation in the entire supply chain. It is noted that the increase in their efficiency is explained by the possibility of transporting various types of cargo, the speed of handling vehicles, as well as the compactness of storage and safety of cargo. The problem of increasing ship capacity on the terms of shipping companies, which currently exists and is being solved by container terminal operators, has been formulated, which allows minimizing the time of ships parking in the port for processing, which in turn can be achieved by increasing the capacity of ships. Attention is drawn to the fact that reducing costs by increasing the efficiency of lifting and transport equipment stimulates investments in automation systems for almost all terminal operations, and in particular in lifting and transport equipment systems. It is emphasized that the automation process of container terminals differs depending on the task at hand (a new project is being considered or work is being carried out to automate an existing terminal). The implementation of automation at existing terminals is a more difficult task due to the problems of compatibility with the types of activities performed and resistance to ongoing changes, which primarily involve systematic and repetitive technological processes that can be programmed. Attention is drawn to the fact that container terminals use the latest operating systems to control and optimize the movement of containers inside the warehouse area (in particular, they are used at terminals where gantry cranes on a pneumatic (RTG) and on a rail (RMG) are used), and it is also emphasized that when working with RTG technology gantry cranes on a pneumatic vehicle are equipped with sensors connected to satellite positioning systems, which are located on the terminal area and on wheeled carts and are brought to the place of cargo operation by signals from the control room, at the same time, the dock operator controls only when lowering or lifting the container. Such information systems are also used on terminals operating using RMG technology. It is noted that automation of berthing container cranes is currently under development, since the complexity of its implementation lies in the fact that during pitching the vessel has a roll and a deflector, therefore, when moving it, it is difficult to determine the exact location of the container and the alignment of the spreader horizon with the container horizon, as a result, the guidance process? It requires additional time, which leads to a decrease in work productivity.

Основные предвестники формирования общепринятых практик осуществления мультимодальных перевозок

The article provides an overview of the history of the emergence of containers, within the framework of such a phenomenon as the container revolution, and also analyzes the modern potential of large transport and logistics infrastructure facilities, as a result and result of the container development trend. As part of the review of the development of modern trends in multimodal transportation, the issue of containerization is quite important, because today a container is not only an equipment for cargo transportation, but also an integral part of the supply chain, and is also able to significantly influence the formation of market tariffs for cargo transportation. Containerization of cargo transportation contributed to the formation of a modern transport and logistics paradigm in the context of international transportation, and also influenced the evolution of existing types of vehicles and special equipment, adapting them to mass transportation of metal containers. Over the history of its existence and development, containers have been adapted for the transportation of a wide variety of types of cargo from dangerous and temperature to bulk and bulk. In this article, within the framework of the calculation unit for assessing the potential of the modern global transport and logistics system, an analysis of the capacity of the largest marine infrastructure facilities - seaports is used, since it was with sea transportation that the containerization process began.

Peran Penentuan Tipe Kapal dan Kargo dalam Memediasi Pengaruh Kepemimpinan dan Komitmen Organisasi terhadap Kinerja Bongkar Muat: Studi Empiris di Perusahaan Pelayaran Wilayah Banten

The purpose of this study is to examine and analyze the role of determining the type of ship and cargo in mediating the influence of leadership and organizational commitment on loading and unloading performance. This study uses primary data obtained from the results of distributing questionnaires via google form to 106 operators at Banten Port. Data is processed using SmartPLS 3.2.9. The results of the study indicate that leadership has a positive and significant effect on loading and unloading performance, organizational commitment has a positive and significant effect on loading and unloading performance, leadership has a positive and significant effect on ship and cargo type, organizational commitment has a positive and significant effect on ship and cargo type, ship and cargo type has a positive and significant effect on loading and unloading performance, ship and cargo type is able to mediate positively and significantly the influence of leadership on loading and unloading performance, ship and cargo type is able to mediate positively and significantly the influence of organizational commitment on loading and unloading performance.

Unveiling risk factors influencing the selection of the Northern Sea Route: A conjoint analysis approach for Japanese shippers

This paper explores how Japanese corporations assess risks associated with using the Northern Sea Route (NSR) as a new maritime transport route in Asia and identifies measures to promote its usage. We address two key questions: (1) What risks influence shippers' route choices in maritime transport? (2) Does risk evaluation vary by cargo type and company size? Using choice-based conjoint analysis and a conditional logit model with online survey data, we identified five main risk factors influencing shippers: route unavailability rate, delay probability, piracy probability, transport costs, and war conditions, ranked in importance from highest to lowest as war conditions, delay probability, transport costs, route unavailability rate, and piracy probability. Additionally, the risk factors significantly influencing route selection were found to be robust, showing minimal variation across company size, type of trade (import/export), and the nature of the goods transported. Our findings suggest several policy implications. Diplomatic efforts are crucial for safe vessel navigation on the NSR. Government initiatives should focus on reducing transport delays through technology investments and implementing strategies to decrease NSR delay rates without increasing shippers' costs. Additionally, emphasizing the lower piracy risks on the NSR compared to Suez Canal Route could boost its attractiveness.

OPTIMIZATION OF LOADING AND UNLOADING WORKS AND PLACEMENT OF TARED AND PIECE CARGOES IN VEHICLES AND WAREHOUSES USING THE METHODS OF ERGONOMICS AND THEORY OF SYSTEMS

Purpose. The tasks of optimizing the placement of tared and piece cargoes (or the task of loading) in a limited volume (capacity) are typical for cases of loading with tared and piece cargoes (mainly large-sized) of transport containers, car bodies, ship holds in the merchant fleet, transport aircraft, railway wagons, areas of the warehouse complex. At the same time, the safe and efficient performance of loading and unloading operations with tared and piece cargoes, including large-sized ones, in a limited space is directly related to taking into account the requirements and using ergonomic methods. The purpose of this paper is to develop a mathematical model for the optimization of the placement of tared and piece cargoes (or about loading) in a limited volume (capacity), which is used to select a subset of cargo units with the maximum relative utility, while observing the limit on the total volume (or mass) of cargo. Methods. The analysis of literary sources made it possible to establish that for modeling and solving the problem of optimizing the placement of cargo (or loading) in a limited volume (capacity), it is rational to use one of the exact solution methods (dynamic programming method), the number of stages of which is the number of types of cargo. The work uses the method of dynamic programming, methods of theory of systems, and linear optimization. Results. The article presents a mathematical model of the problem of optimal placement of tared and piece cargoes (or about loading) in a limited volume, and for the case of placing weapons, ammunition, weapons, it is proposed to maximize not the function of the total cost (value) of the cargo, but the function that would take into account the relative usefulness of each cargo. The relative usefulness of each cargo is proposed to be determined by expert methods of systems theory, for example, the Delphi method, which is well formalized and suitable for computer processing of results. Scientific novelty. The scientific novelty consists in the development of a mathematical model that allows solving the problem of optimal placement of container loads (or loading) in a limited volume, and the target function of the optimization model is proposed to be the total relative usefulness of the cargo. Practical significance. Defined ergonomic requirements for cargo operations with tared and piece cargoes in a limited space (vehicles, warehouses). A method of numerical calculation based on the model is proposed (the case of loading a car body with tared and piece cargoes). In further research, the obtained results will be used for computer simulation according to the developed model using the Solver tool of Microsoft Excel.

Road accident risk analysis of at- and near-port areas reflecting regional heterogeneous characteristics

ABSTRACT In port cities, road traffic safety management should consider various types of cargo that will shift in the trucks and containers. This applies not only in the case of ‘at port’ areas within a 2-km radius but also ‘near-port’ areas within a 4–8-km radius. This is important for traffic safety because the crash severity can be high as there are many trucks to the ports that can cause large-scale crashes. Therefore, to prepare traffic safety management strategies for port city, it is necessary to identify crash risk factors that affect the crash severity. This study developed a two-stage road crash severity model of ‘at-port’ and ‘near-port’ regions using a support vector machine and a Bayesian multinomial model. Additionally, a severity model suitable for Korean ports was proposed that considered spatial heterogeneity in the Bayesian multilevel multinomial model. Findings derived from this study can be used for policy development to increase road traffic safety in port cities. ‘This article is a revised and expanded version of a paper entitled [Accident Risk Analysis of At and Near-Port Areas Reflecting Regional Heterogeneous Characteristics] presented at [The 11th International Conference on Logistics and Maritime Systems, Korea, 4-7 September 2023]’.

A risk assessment of inhibited cargo operations in maritime transportation: a case of handling styrene monomer

Hazardous cargo handling on tanker ships involves various risks that could lead to accidents such as explosion and fire. Investigating these risks is crucial to safeguard life, property and the marine environment. This paper performs a risk assessment specific to hazardous cargoes with special requirements. It addresses the risks of inhibited cargo operation, which has not been adequately studied in the literature despite its criticality. Styrene monomer is selected as the inhibited cargo type since failures during its handling may lead to polymerisation and catastrophic consequences. Using the Failure Modes, Effects and Criticality Analysis (FMECA) 24 failures are identified, and their occurrence, severity and detection aspects are evaluated by experts familiar with the process. In addition, a rule-based fuzzy logic technique with Gaussian membership functions is employed to support the traditional FMECA application. The integration of methods helps to deal with the limitations of FMECA in the calculation of risk priority number (RPN). Based on the fuzzy RPN results, failure modes are prioritized and preventive actions are presented for the high-ranked failure modes. The outputs of the study could help to increase the awareness of operators and interested individuals concerning the risks of tanker cargo operations with special requirements.

Reconstructing and assessing global maritime transport network: based on the Port Cargo Composite Transport index

ABSTRACT Solution to the problem of limited explanatory power of transport economics due to the homogenisation of existing the Global Maritime Transport Network (GMTN) construction indicators. By integrating the Port Cargo Composite Transport (PCCT) index and considering the volume-value mismatch relationship and the type and flow of cargo transported in ports, the GMTN can be reconstructed through a bottom-up logic. Combining the complex network, natural breaks, and point mutual information method with the Leiden and PageRank algorithm, the characteristics of the GMTN were derived from three aspects, i.e. network topology, node characteristics, and inter-node dependency. The GMTN presents the characteristics as follows. Community division presents typical geographical aggregation and industrial complementarity. Node characteristics show the classic phenomenon of rich people’s clubs, with obvious heavy-tailed distribution. Maritime transport linkage preferences present a phenomenon of geographical proximity, and their expansion can clarify the direction of the main links. Enhancing their maritime links will be more targeted to support the transport of trade cargoes. These findings help us to understand the characteristics of the international maritime trade pattern, and provide decision references for industry stakeholders to provide a strategic layout of maritime transport.

Drug delivery based exosomes uptake pathways

Most cells secrete a material called extracellular vesicles (EVs), which play a crucial role in cellular communication. Exosomes are one of the most studied types of EVs. Recent research has shown the many functions and substrates of cellular exosomes. Multiple studies have shown the efficacy of exosomes in transporting a wide variety of cargo to their respective target cells. As a result, they are often utilized to transport medicaments to patients. Natural exosomes as well as exosomes modified with other compounds to enhance transport capabilities have been employed. In this article, we take a look at how different types of exosomes and modified exosomes may transport different types of cargo to their respective targets. Exosomes have a lot of potential as drug delivery vehicles for many synthetic compounds, proteins, nucleic acids, and gene repair specialists because they can stay in the body for a long time, are biocompatible, and can carry natural materials. A good way to put specific protein particles into exosomes is still not clear, though, and the exosomes can't be used in many situations yet. The determinants for exosome production, as well as ways for loading certain therapeutic molecules (proteins, nucleic acids, and small compounds), were covered in this paper. Further study and the development of therapeutic exosomes may both benefit from the information collected in this review.

Nanomedicine Strategies Utilizing Lipid-Based Nanoparticles for Liver Cancer Therapy: Exploring Signaling Pathways and Therapeutic Modalities.

Liver cancer, specifically hepatocellular carcinoma (HCC), is the second leading cause of cancer-related deaths, following pancreatic cancer. The 5-year overall survival rate for HCC remains relatively low. Currently, there are multiple treatment options available for HCC, including systemic drugs, minimally invasive local therapies such as radiofrequency ablation, transarterial chemoembolization (TACE), and arterial radioembolization (TARE), as well as surgical interventions like liver resection or transplantation. However, the effectiveness of drug delivery to the cancerous liver is hindered by pathophysiological changes in the organ. In order to address this challenge, lipid-based nanoparticles (LNPs) have emerged as promising platforms for delivering a diverse range of therapeutic drugs. LNPs offer various structural configurations that enhance their physical stability and enable them to accommodate different types of cargo with varying mechanical properties and degrees of hydrophobicity. In this article, we provide a comprehensive review of the current applications of LNPs in the development of anti-HCC therapies. By examining the existing research, we aim to shed light on the potential future directions and advancements in this field.

Selection model of chemical tanker ships for cargo types using fuzzy AHP and fuzzy TOPSIS

There are many chemical tanker ships on the market with very different characteristics. However, their operational performance for cargo types remains uncertain. Also, it is unclear which criteria should be taken into consideration primarily in the selection of chemical tanker ships. Therefore, choosing the most suitable ones for the cargo to be transported is an important problem for maritime companies. In this respect, the study aims to determine suitable chemical tanker ships for the four main cargo groups transported by them: animal and vegetable oils, corrosives (abrasives), organic chemicals, and petroleum products. A methodology that combines the fuzzy AHP, fuzzy TOPSIS, and clustering methods is used. 30 alternative chemical tanker ships are determined to represent the characteristics of all ships with a tonnage of 1–30 k DWT on the market. They are clustered into performance levels according to their fuzzy TOPSIS ranking scores. Consequently, a chemical tanker selection manual is developed based on the common characteristics of high-performance ships as well as the order of importance of criteria. It is envisaged that it would be a reference for ship operators and shipowners in the selection of suitable ships for the type of cargo.

Portside-shipside interaction on shore-power installation: A perspective of tramp shipping deployment

Due to the high initial costs and the uncertain returns of investment, the efficient green technology in shipping industry, shore power (SP), is still in a developmental dark age, especially its installation at bulk terminals and ships. This study examines the factors influencing the SP installation for bulk terminals and ships, elucidates the impacting mechanisms of one party's installation on the investment returns of the other, and reveals the decisive role of fleet operations in the installation decisions of both parties and corresponding carbon emissions. Employing a dataset representing real-world shipping routes and cargo types, the ship-cargo matching and ships' port-of-calls within a planning horizon are optimized with the objective of maximizing the profit of tramp shipping business by taking SP installation and usage cost into account. Portside SP decision-making model is also conducted to estimate the revenue generated by portside SP usage, and guide portside installation decisions based on the cost-benefit ratio. Finally, recommendations are proposed for ship owner, port operator and government to collaboratively navigate through the dark age of SP development, supported by the further discussion regarding fuel-electricity price gap and port loading efficiency.

RESEARCH OF CHANGES IN THE POWER OF CAR FLOW AT THE SHUTTING STATION DURING THE PERIOD OF MILITARY ACTIONS

It is impossible to solve the problem of improving the system of organizing car flows in trains at the current level of information support without creating an information and management system that will integrate into a single information and computing space the most important optimization tasks covering all levels of managing the process of freight transportation on railway transport, such as such as the calculation of the routing of car flows from loaded and empty cars, the calculation of the plan for the formation of freight trains at the training ground of the main technical stations, the calculation of the plan for the formation of local trains in the areas of local work, and the construction of adjusted operational plans for the operation of stations. The aggression of the Russian Federation against Ukraine fundamentally changed the system of railway transport of Ukraine. The volume of cargo transportation by rail transport during military operations in the east of Ukraine decreased by 37% in 2022, but already in 2023, an increase in the transportation of some types of cargo began, in particular, grain cargo, mineral construction materials, dangerous bulk cargoes, military equipment. Transportation of goods by railways of Ukraine, especially during military operations, is not carried out evenly over a long period of time and has fluctuations in the capacity of car flows. The updated directions of their tracking, which depend on the technical condition of the railway infrastructure for the current period, lead to a change in the direction of tracking of car flows and, as a consequence, their organization into trains according to the formation plan at technical stations. The conducted studies established that the capacities of car flows are random values, therefore it is advisable to use mathematical statistics methods for their description, and modeling methods for forecasting work with them. Those car flows that arrive at the sorting station most of all fall under the geometric law of distribution of a random variable depending on the power of the direction of arrival, which has a significant impact on the accumulation parameter at the station. Fluctuations in the capacity of car flows are quite significant and depend on a sufficiently large number of factors. For the operational planning of the work of sorting stations, it is necessary to take the characteristics of the current state or a sample of data for short periods (a decade, a week), that is, it is necessary to constantly analyze the data from the ASK of the VP UZ - there is, therefore, a study of the capacity of car flows in the technical station during the period of changing their directions is an actual task and can be used to adjust the dispatcher routing and the plan for the formation of single-group and group freight trains.

FAULT TREE METHOD AS A DECISION-MAKING TOOL FOR ASSESSING THE RISKS OF TRANSPORTATION OF DANGEROUS LOADS

Improving road traffic safety on the one hand and increasing the transport of dangerous goods on the other requires searching for methods and tools for risk assessment at various levels of transport of this type of cargo. This is directly related to the disruption of the safety and efficiency of road transport systems around transporting dangerous goods. In this respect, risk assessment and its estimation method are a significant issue. The article analyzes the risk resulting from the transport of dangerous goods. Threats occurring during the organization and execution of the transport of dangerous goods were identified and risk assessment studies were carried out using the FTA method (fault tree method). The purpose of using the FTA method was to develop and graphically illustrate a set of factors that cause adverse events in the transport of dangerous goods. TopEvent FTA computer software was used to verify the proposed approach, which is used both to construct error trees and to identify and correct irregularities in existing trees.

What's on a prophage: analysis of Salmonella spp. prophages identifies a diverse range of cargo with multiple virulence- and metabolism-associated functions.

Lysogenic bacteriophages (phages) can integrate their genome into a bacterial host's genome, potentially introducing genetic elements that can affect the fitness of the host bacterium. The functions of prophage-encoded genes are important to understand as these genes could be mobilized and transferred to a new host. Using a large genomic dataset representing >300 isolates from all known subspecies and species of Salmonella, our study contributes important new findings on the distribution of prophages and the types of cargo that diverse Salmonella prophages carry. We identified a number of coding sequences (CDSs) annotated as having cell surface-modifying attributes, suggesting that prophages may have played an important role in shaping Salmonella's diverse surface antigen repertoire. Furthermore, our characterization of prophages suggests that they play a broader role in facilitating the acquisition and transfer of CDSs associated with metabolism, DNA replication and repair, virulence factors, and to a lesser extent, antimicrobial resistance.