Wind energy stands as one of the most important renewable energy sources. Large scale wind turbine blades are mainly based on fiber reinforced polymer composites, as an efficient way to further improve their performance reducing the weight of their blades. The problem of the microstructure material failure of the interior support mechanism for a – high power – horizontal axis wind turbine blade is investigated in this study. A finite element model is developed, simulating the load-bearing box girder of the blade with a given airfoil shape, size, type, and position of the interior longitudinal beams and shear-webs. Previous work showed the challenging topics of material properties, design, computational analysis techniques, and load response of a blade cross-section. In order to shed some light at a local level, a comparison of the most common composite blade materials concerning stress distributions and also displacements, which are critical for optimal blade design, is presented. A failure criterion is applied based on the shell finite element analysis of the model, in order to demonstrate the stress levels throughout every ply of the composite materials of the box girder and locate the initiation of fracture. Failure results concerning both glass and carbon materials are presented.