The simultaneous two-parameter estimation problem in a single squeezed-light Mach–Zehnder interferometer with the double-port homodyne detection is investigated in this work. The analytical form of the two-parameter quantum Cramér–Rao bound defined by the quantum Fisher information matrix is presented, which shows the ultimate limit of the phase sensitivity will be further approved by the squeezed vacuum state. It can not only surpass the standard quantum limit, but also can even surpass the Heisenberg limit when half of the input intensity of the interferometer is provided by the coherent state and half by the squeezed light. For the double-port homodyne detection, the classical Fisher information matrix is also obtained. Our results show that although the classical Cramér–Rao bound does not saturate the quantum one, it can still asymptotically approach the quantum Cramér–Rao bound when the intensity of the coherent state is large enough. Our results also indicate that the squeezed vacuum state indeed can further improve the phase sensitivity, similar to the single-parameter estimation. In addition, when half of the input intensity of the interferometer is provided by the coherent state and half by the squeezed light, the phase sensitivity obtained by the double-port homodyne detection can also surpass the Heisenberg limit for a small range of the estimated phases.