We have constructed a new kind of two-mode bosonic realization of SU(1,1) Lie algebra, on the basis of which the SU(1,1) generalized coherent states in the two-mode Fock space are derived. These two-mode SU(1,1) coherent states, which are called uncorrelated two-mode SU(1,1) coherent states, include three special cases. For these states, we study the mean photon number distribution and their non-classical properties, which are photon anti-bunching, violations of Cauchy-Schwarz inequality and two-mode squeezing.