Abstract The absence of buoyancy driven thermal instabilities in space offers an ideal environment for the growth of defect-free high temperature superconducting thin films. Terrestrially processed thin film specimens as well as bulk single crystals, especially when grown by a melt method like the liquid phase epitaxy (LPE), suffer computational inhomogeneities which are introduced by the thermal instabilities caused by the earth's gravitational force. This leads to the nucleation of various types of defects in the material which adversely influence its fundamental physical, chemical, structural and mechanical properties. This drastically inhibits its technological usefulness. High quality epitaxial layers of the 2122-phase of BiCaSrCu--oxide (BCSCO) having single crystalline structure have been grown by the optimization of the LPE process. The films were grown on twin free single crystals substrates of NdGaO3 from supersaturated solutions of KCl and BCSCO. Of the commonly used substrates for the growth of high-Tc films, NdGaO3 has a unique advantage of having a very small lattice mismatch, of about 0.4%, with the 2122-phase of BCSCO. The temperature regime of 850 to 830 °C is found to be the most suitable range for the formation of epitaxial layers of the 2122-phase on NdGaO3 substrates. X-ray diffraction, SEM and TEM studies reveal the excellent epitaxial and single crystalline nature of the films. Compositional analysis is carried out by the Rutherford Back Scattering (RBS) technique. Also, these films exhibit 100% reflectivity in the far infrared regime of 2 to 25 microns. The standard 4-point probe resistivity measurement shows the onset of superconductivity at 90 K and the zero resistance at 83 K. These LPE experiments, if conducted in the microgravity environment of space, should allow us to grow superior films of the 80 K phase of BCSCO with no or minimal defects. The results obtained on space grown samples will not only be of immense value for understanding the physical mechanisms of this unique phenomenon rather it will also help in introducing improvements in the growth technology on earth to produce high quality samples for various electronic and photonic applications.