Based on an eddy-permitting ocean circulation model, the eddy kinetic energy (EKE) sources are studied in the Sea of Okhotsk. An analysis of the spatial distribution of the EKE showed that intense mesoscale variability occurs along the western boundary of the Sea of Okhotsk, where the East-Sakhalin Current extends. It was found a pronounced seasonally varying EKE with its maximal magnitudes in winter, and its minimal magnitudes in summer. An analysis of the EKE sources and the energy conversions showed that time-varying (turbulent) wind stress is a main contribution to mesoscale variability along the western boundary of the Sea of Okhotsk. The contribution of baroclinic instability to the generation of mesoscale variability predominates over that of barotropic instability along the western boundary of the Sea of Okhotsk. To demonstrate the mechanism of baroclinic instability, the circulation was considered along the western boundary of the Sea of Okhotsk from January to April 2005. An analysis of hydrological conditions showed outcropping isopycnals and being strong vertical shear of the along-shore velocity from January to May 2005. In April, mesoscale eddies are observed along the western boundary of the Sea of Okhotsk. It was established that seasonal variability of turbulent wind stress and the baroclinic instability of the East-Sakhalin Current are major reasons of mesoscale variability along the western boundary of the Sea of Okhotsk.