Asymmetrical V-shaped tunnels often appear in tunnels crossing the river or urban underground road tunnels. The smoke flow inside is affected by a lot of factors. A full understanding of the smoke flow in this kind of tunnel is the basis of the smoke control. In this study, the effects of slope composition and fire heat release rate (HRR) on the longitudinal induced airflow velocity, the smoke back-layering length at the small slope side, and the maximum ceiling temperature were studied by the numerical method. The results show that when the fire occurs at the slope change point of the V-shaped tunnel, the maximum ceiling temperature decreases with the increase in the slope of the large-slope side tunnel. The longitudinally induced velocity is primarily related to the slope of the large-slope side tunnel and the fire HRR. When the slope difference between the side tunnels or the slope of the large-slope side tunnel is large, the smoke in the small-slope side tunnel flows back toward the fire source after reaching its maximum dispersion distance and then reaches a quasi-steady state. The smoke back-layering length is mainly affected by the slope and length of the large-slope side tunnel. When the slope of the large-slope side tunnel is 9%, the induced airflow velocity from the small-slope side can prevent the spread of smoke. The empirical models of the smoke back-layering length and the longitudinal induced airflow velocity in the small-slope side tunnel are drawn, respectively, by the theoretical analysis and the numerical results. This study can provide technical support for the design and operation of smoke control systems in V-shaped tunnels.