Tunable Physicochemical Properties Research Articles

Unlocking the Potential of CO2 Capture: A Synergistic Hybridization Strategy for Polymeric Hydrogels with Tunable Physicochemical Properties.

Unlocking CO2 capture potential remains a complex and challenging endeavor. Here, a blueprint is crafted for optimizing materials through CO2 capture and developing a synergistic hybridization strategy that involves synthesizing CO2-responsive hydrogels by integrating polymeric networks interpenetrated with polyethyleneimine (PEI) chains and inorganic CaCl2. Diverging from conventional CO2 absorbents, which typically serve a singular function in CO2 capture, these hybrid PEAC hydrogels additionally harness its presence to tune their optical and mechanical properties once interacting with CO2. Such synergistic functions entail two significant steps: (i) rapid CO2-fixing through PEI chains to generate abundant carbamic acid and carbamate species and (ii) mineralization via CaCl2 to induce the formation of CaCO3 micro-crystals within the hydrogel matrix. Due to the reversible bonding, the PEAC hydrogels enable the decoupling of CO2 through an acid fumigation treatment or a heating process, achieving dynamic CO2 capture-release cycles up to 8 times. Furthermore, the polyethyleneimine-acrylamide-calcium chloride (PEAC) hydrogel exhibits varying antibacterial attributes and high interfacial adhesive strength, which can be modulated by fine-tuning the compositions of PEI and CaCl2. This versatility underscores the promising potential of PEAC hydrogels, which not only unlocks CO2 capture capabilities but also offers opportunities in diverse biological and biomedical applications.

Advances in Aluminophosphates for Catalytic Upgrading of Lignocellulose and Derived Compounds

Utilization of lignocellulosic biomass as a renewable resource to produce liquid fuels/fuel additives and commodity chemicals offer solutions to minimize the exhaustion of nonrenewable carbon‐based fossil resources and mitigate environmental problems. Cellulose and hemicellulose derived from lignocellulose can be converted into several important platform molecules like glucose, fructose, xylose, 5‐hydroxymethylfurfural, furfural, levulinic acid, etc., which subsequently can be transformed into fuels/fuel additives and value‐added chemicals using heterogeneous catalytic processes. Aluminophosphates (AlPO‐n) are zeotype materials with tunable physicochemical properties like acidity and porosity, and this have promoted their wide use as versatile catalysts for several acid‐catalyzed reactions, including hydrolysis, dehydration, isomerization, transfer hydrogenation, reductive etherification, acetalization and aldol condensation. This review summarizes the design and synthetic advances of AlPO‐n catalysts as well as their application in the valorization of lignocellulose and derivatives to platform chemicals and fuel compounds. Perspectives for future design strategies are finally outlined

Stimuli-Responsive Hydrogels for Antibacterial Applications.

Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical properties, and excellent biocompatibility. The integration of stimuli-responsive functions into antibacterial hydrogels holds the potential to enhance their antibacterial properties and therapeutic efficacy, dynamically responding to different external or internal stimuli, such as pH, temperature, enzymes, and light. Therefore, this review describes the applications of hydrogel dressings responsive to different stimuli in antibacterial therapy. The collaborative interaction between stimuli-responsive hydrogels and antibacterial materials was discussed. This synergistic approach, in contrast to conventional antibacterial materials, not only amplifies the antibacterial effect but also alleviates adverse side effects and diminishes the incidence of multiple infections and drug resistance. The review provides a comprehensive overview of the current challenges and outlines future research directions for stimuli-responsive antibacterial hydrogels. It underscores the imperative for ongoing interdisciplinary research aimed at unraveling the mechanisms of wound healing. This understanding is crucial for optimizing the design and implementation of stimuli-responsive antibacterial hydrogels. Ultimately, this review aims to offer scientific guidance for the development and practical clinical application of stimuli-responsive antibacterial hydrogel dressings. This article is protected by copyright. All rights reserved.

Research on synthesis of imidazole-based ionic liquids as metal corrosion inhibitors

Ionic liquids (ILs) have gained significant attention in recent years as potential corrosion inhibitors to various applications. Traditional corrosion inhibitors, such as organic compounds and inorganic salts, have limitations in terms of toxicity, volatility, and environmental impact. However, ionic liquids offer a promising alternative. Ionic liquids are salts that exist in a liquid state at or below 100 degrees Celsius. They typically comprise an organic cation and an inorganic or organic anion. The unique combination of a liquid state and ionic nature gives them several advantageous properties, such as high thermal stability, low vapor pressure, and tunable physicochemical properties. Additionally, the charged nature of the ionic liquid allows for electrochemical interactions with the metal surface, further enhancing corrosion inhibition. In this paper, imidazole-based ionic liquids were synthesized by alkylation of imidazole derivatives using 1-bromohexadecane. The anti-corrosion properties of the material were evaluated using the weight method and potentiodynamic polarization method. Results showed that the synthesized ILs are good corrosion inhibitor for CT3 steel.

Rescuing a Troubled Tolcapone with PEGylated PLGA Nanoparticles: Design, Characterization, and Hepatotoxicity Evaluation.

Tolcapone is an orally active catechol-O-methyltransferase (COMT) inhibitor used as adjuvant therapy in Parkinson's disease. However, it has a highly hepatotoxic profile, as recognized by the U.S. Food and Drug Administration. As a possible solution, nanoscience brought us several tools in the development of new functional nanomaterials with tunable physicochemical properties, which can be part of a solution to solve several drawbacks, including drug's short half-life and toxicity. This work aims to use PEGylated poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a stable carrier with lower hydrodynamic size and polydispersity to encapsulate tolcapone in order to overcome its therapeutic drawbacks. Using the nanoprecipitation method, tolcapone-loaded nanoparticles with a DLC% of 5.7% were obtained (EE% of 47.0%) and subjected to a lyophilization optimization process to obtain a final shelf-stable formulation. Six different cryoprotectants in concentrations up to 10% (w/v) were tested. A formulation of PLGA nanoparticles with 3% hydroxypropyl-β-cyclodextrin (HPβCD) as a cryoprotectant (PLGA-HP@Tolc), presenting sub-200 nm sizes and low polydispersity (PdI < 0.200) was selected. Cytotoxicity assays, namely, MTT and SRB, were used to study the metabolic activity and cell density of tolcapone and PLGA-HP@Tolc-treated cells. In both assays, a hepatocarcinoma cell line (HepG2) growing in glucose or glucose-free media (galactose-supplemented medium) was used. The results demonstrated that the treatment with the PLGA-HP@Tolc formulation led to a decrease in cytotoxicity in comparison to free tolcapone-treated cells in both media tested. Moreover, the elected formulation also counteracted ATP-depletion and excessive ROS production induced by tolcapone. The results suggest that HPβCD might have a dual function in the formulation: cryoprotectant and anticytotoxic agent, protecting cells from tolcapone-induced damage. Using an in vitro COMT inhibition assay, the PLGA-HP@Tolc formulation demonstrated to inhibit COMT as efficiently as free tolcapone. Overall, the results suggest that tolcapone-loaded PLGA NPs could be an interesting alternative to free tolcapone, demonstrating the same in vitro efficacy in inhibiting COMT but with a safer cytotoxic profile.

Diversity in Atomic Structures of Zeolite-Templated Carbons and the Consequences for Macroscopic Properties.

Zeolite-templated carbons (ZTCs) are a family of ordered microporous carbons with extralarge surface areas and micropore volumes, which are synthesized by carbon deposition within the confined spaces of zeolite micropores. There has been great controversy regarding the atomic structures of ZTCs, which encompass two extremes: (1) three-dimensionally connected curved open-blade-type carbon moieties and (2) ideal tubular structures (commonly referred to as "Schwarzites"). In this study, through a combination of experimental analyses and theoretical calculations, we demonstrate that the atomic structure of ZTCs is difficult to define as a single entity, and it widely varies depending on their synthesis conditions. Carbon deposition using a large organic precursor and low-temperature framework densification generates ZTCs predominantly composed of open-blade-type moieties, characterized by low surface curvature and abundant H-terminated edge sites. Meanwhile, synthesis using a small precursor with high-temperature densification produces ZTCs with an increased portion of closed-strut carbon moieties (or closed-fullerene-like nodes), exhibiting large surface curvature and diminished edge sites. The variations in the atomic structure of ZTCs result in significant differences in their macroscopic properties, such as N2/CO2 adsorption, oxidative stability, work function, and electrocatalytic properties, despite the presence of comparable pore structures. Therefore, ZTCs demonstrate the potential to synthesize ordered nanoporous carbons with tunable physicochemical properties.

Controlled Release of Drugs from Extracellular Matrix-Derived Peptide-Based Nanovesicles through Tailored Noncovalent Interactions.

Elastin-collagen nanovesicles (ECnV) have emerged as a promising platform for drug delivery due to their tunable physicochemical properties and biocompatibility. The potential of nine distinct ECnVs to serve as drug-delivery vehicles was investigated in this study, and it was demonstrated that various small-molecule cargo (e.g., dexamethasone, methotrexate, doxorubicin) can be encapsulated in and released from a set of ECnVs, with extents of loading and rates of release dictated by the composition of the elastin domain of the ECnV and the type of cargo. Elastin-like peptides (ELPs) and collagen-like peptides (CLPs) of various compositions were produced; the secondary structure of the corresponding peptides was determined using CD, and the morphology and average hydrodynamic diameter (∼100 nm) of the ECnVs were determined using TEM and DLS. It was observed that hydrophobic drugs exhibited slower release kinetics than hydrophilic drugs, but higher drug loading was achieved for the more hydrophilic Dox. The collagen-binding ability of the ECnVs was demonstrated through a 2D collagen-binding assay, suggesting the potential for longer retention times in collagen-enriched tissues or matrices. Sustained release of drugs for up to 7 days was observed and, taken together with the collagen-binding data, demonstrates the potential of this set of ECnVs as a versatile drug delivery vehicle for longer-term drug release of a variety of cargo. This study provides important insights into the drug delivery potential of ECnVs and offers useful information for future development of ECnV-based drug delivery systems for the treatment of various diseases.

Deep eutectic solvents as green and sustainable diluents in headspace gas chromatography for the determination of trace level genotoxic impurities in pharmaceuticals

Genotoxic impurities (GTIs) are potential carcinogens that need to be controlled down to ppm or lower concentration levels in pharmaceuticals under strict regulations. The static headspace gas chromatography (HS-GC) coupled with electron capture detection (ECD) is an effective approach to monitor halogenated and nitroaromatic genotoxins. Deep eutectic solvents (DESs) possess tunable physico-chemical properties and low vapor pressure for HS-GC methods. In this study, zwitterionic and non-ionic DESs have been used for the first time to develop and validate a sensitive analytical method for the analysis of 24 genotoxins at sub-ppm concentrations. Compared to non-ionic diluents, zwitterionic DESs produced exceptional analytical performance and the betaine : 7 (1,4- butane diol) DES outperformed the betaine : 5 (1,4-butane diol) DES. Limits of detection (LOD) down to the 5-ppb concentration level were achieved in DESs. Wide linear ranges spanning over 5 orders of magnitude (0.005–100 µg g−1) were obtained for most analytes with exceptional sensitivities and high precision. The method accuracy and precision were validated using 3 commercially available drug substances and excellent recoveries were obtained. This study broadens the applicability of HS-GC in the determination of less volatile GTIs by establishing DESs as viable diluent substitutes for organic solvents in routine pharmaceutical analysis.

Liposome-integrated hydrogel hybrids: Promising platforms for cancer therapy and tissue regeneration

Drug delivery platforms have gracefully emerged as an indispensable component of novel cancer chemotherapy, bestowing targeted drug distribution, elevating therapeutic effects, and reducing the burden of unwanted side effects. In this context, hybrid delivery systems artfully harnessing the virtues of liposomes and hydrogels bring remarkable benefits, especially for localized cancer therapy, including intensified stability, excellent amenability to hydrophobic and hydrophilic medications, controlled liberation behavior, and appropriate mucoadhesion to mucopenetration shift. Moreover, three-dimensional biocompatible liposome-integrated hydrogel networks have attracted unprecedented interest in tissue regeneration, given their tunable architecture and physicochemical properties, as well as enhanced mechanical support. This review elucidates and presents cutting-edge developments in recruiting liposome-integrated hydrogel systems for cancer treatment and tissue regeneration.

Ionic Liquid Interface as a Cell Scaffold.

In sharp contrast to conventional solid/hydrogel platforms, water-immiscible liquids, such as perfluorocarbons and silicones, allow the adhesion of mammalian cells via protein nanolayers (PNLs) formed at the interface. However, fluorocarbons and silicones, which are typically used for liquid cell culture, possess only narrow ranges of physicochemical parameters and have not allowed for a wide variety of cell culturing environments. In this paper, it is proposed that water-immiscible ionic liquids (ILs) are a new family of liquid substrates with tunable physicochemical properties and high solvation capabilities. Tetraalkylphosphonium-based ILs are identified as non-cytotoxic ILs, whereon human mesenchymal stem cells are successfully cultured. By reducing the cation charge distribution, or ionicity, via alkyl chain elongation, the interface allows cell spreading with matured focal contacts. High-speed atomic force microscopy observations of the PNL formation process suggest that the cation charge distribution significantly altered the protein adsorption dynamics, which are associated with the degree of protein denaturation and the PNL mechanics. Moreover, by exploiting dissolution capability of ILs, an ion-gel cell scaffold is fabricated. This enables to further identify the significant contribution of bulk subphase mechanics to cellular mechanosensing in liquid-based culture scaffolds.

Direct assembly of N-sulfamoyl lactam scaffolds bearing a zinc-binding group for inhibiting metalloenzymes based on desymmetrization of sulfamide and the Castagnoli-Cushman reaction

Sulfamide was desymmetrized by a reaction with aldehydes to give N-sulfamoylimines. The latter reagents were successfully introduced into diastereo- and chemoselective transformation with cyclic anhydride using the Castagnoli-Cushman reaction to give unprotected N-sulfamoyl tetrahydroisoquinolonic (THIQ) acids under simple metal-free protocol. Thereby, the first general approach to the direct assembly of six-membered N-sulfamoyl lactams was developed. The synthesized compounds belong to representative, drug-like chemotypes with their well-defined three-dimensional structures and tunable physicochemical properties. In an attempt to probe their pharmacological potential, the newly synthesized lactams were screened against therapeutically relevant human and bacterial carbonic anhydrases, with some derivatives showing low micromolar enzyme inhibitory profiles.

Applications of Emerging Metal and Covalent Organic Frameworks in Perovskite Photovoltaics: Materials and Devices

AbstractPerovskite solar cells (PSCs) have emerged as the next generation photovoltaic technology due to their high power conversion efficiency and solution‐based fabrication process. The performance of PSCs relies on the composition of each layer and the interface properties between layers. Hence, the integration of novel materials into PSCs presents a viable strategy for enhancing device performance. Metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) have recently emerged as promising materials for improving the efficiency and stability of PSCs. These materials offer a diverse range of tunable physicochemical properties and functionalities. This comprehensive review aims to provide an in‐depth summary of the progress in utilizing MOFs/COFs in PSCs. The review covers key aspects such as their electronic properties, synthesis methods, and various applications within PSCs, including their role as different components and their potential as lead absorbents. Finally, the review outlines important challenges and highlights future prospects for advancing this technology.

Characterization and antitumor effect of doxorubicin-loaded Fe3O4-Au nanocomposite synthesized by electron beam evaporation for magnetic nanotheranostics.

Magnetic nanocomposites (MNC) are promising theranostic platforms with tunable physicochemical properties allowing for remote drug delivery and multimodal imaging. Here, we developed doxorubicin-loaded Fe3O4-Au MNC (DOX-MNC) using electron beam physical vapor deposition (EB-PVD) in combination with magneto-mechanochemical synthesis to assess their antitumor effect on Walker-256 carcinosarcoma under the influence of a constant magnetic (CMF) and electromagnetic field (EMF) by comparing tumor growth kinetics, magnetic resonance imaging (MRI) scans and electron spin resonance (ESR) spectra. Transmission (TEM) and scanning electron microscopy (SEM) confirmed the formation of spherical magnetite nanoparticles with a discontinuous gold coating that did not significantly affect the ferromagnetic properties of MNC, as measured by vibrating-sample magnetometry (VSM). Tumor-bearing animals were divided into the control (no treatment), conventional doxorubicin (DOX), DOX-MNC and DOX-MNC + CMF + EMF groups. DOX-MNC + CMF + EMF resulted in 14% and 16% inhibition of tumor growth kinetics as compared with DOX and DOX-MNC, respectively. MRI visualization showed more substantial tumor necrotic changes after the combined treatment. Quantitative analysis of T2-weighted (T2W) images revealed the lowest value of skewness and a significant increase in tumor intensity in response to DOX-MNC + CMF + EMF as compared with the control (1.4 times), DOX (1.6 times) and DOX-MNC (1.8 times) groups. In addition, the lowest level of nitric oxide determined by ESR was found in DOX-MNC + CMF + EMF tumors, which was close to that of the muscle tissue in the contralateral limb. We propose that the reason for the relationship between the observed changes in MRI and ESR is the hyperfine interaction of nuclear and electron spins in mitochondria, as a source of free radical production. Therefore, these results point to the use of EB-PVD and magneto-mechanochemically synthesized Fe3O4-Au MNC loaded with DOX as a potential candidate for cancer magnetic nanotheranostic applications.

Critical assessment of interactions between ct-DNA and choline-based magnetic ionic liquids: evidences of compaction.

Ionic liquids (ILs) have become an alternative green solvent for storage and for stability of DNA. However, an in-depth understanding of binding and molecular interactions between ILs and DNA is needed. In this respect, magnetic ILs (MILs) are promising due to their tunable physicochemical properties. Various spectroscopic techniques and molecular simulations have been employed to unravel the critical factors of the strength and binding mechanism of MILs with DNA. UV-vis spectra unravel the multimodal binding of MILs with DNA, and the intrusion of IL molecules into the minor groove of DNA has been observed from dye displacement studies. Fluorescence correlation spectroscopic studies and scanning electron microscopy confirm the compaction of the DNA. ITC and molecular docking studies estimate the binding affinity of DNA with MILs, of ∼7 kcal mol-1. The 1 μs long-MD simulations give insight into the structural changes in the DNA in the MIL environment. Due to strong interaction with choline ions in the close vicinity, DNA helixes bend or squeeze in length and dilate in diameter (elliptical → spherical), leading to compaction. The post-MD parameters suggest a stronger interaction with [Ch]2[Mn] IL than with [Ch][Fe] IL; hence, the former induces DNA compaction to a more significant extent. Furthermore, decompaction is observed with the addition of sodium salts and is characterized using spectroscopic methods.

3D printing of reactive macroporous polymers via thiol-ene chemistry and polymerization-induced phase separation.

Using thiol-ene chemistry, polymerization-induced phase separation, and DLP 3D printing, we present a method for manufacturing reactive macroporous 3D structures. This approach enables the fabrication of structures with tunable physicochemical properties and compressibility. Moreover, it facilitates post-functionalization through thiol-Michael addition reactions, thereby expanding performance and application potential.

Electrostatic co-assembly of FePS3 nanosheets and surface functionalized BCN heterostructures for hydrogen evolution reaction.

Advances in the hydrogen evolution reaction (HER) are intricately connected with addressing the current energy crisis and quest for sustainable energy sources. The necessity of catalysts that are efficient and inexpensive to perform the hydrogen evolution reaction is key to this. Following the ground-breaking discovery of graphene, metal thio/seleno phosphates (MPX3: M - transition metal, P - phosphorus and X - S/Se), two dimensional (2D) materials, exhibit excellent tunable physicochemical, electronic and optical properties, and are expected to be key to the energy industry for years to come. Taking this into account, a facile time-effective electrostatic restacking synthesis procedure has been followed to synthesize a 2D/2D heterostructure (FePS3@BCN) involving FePS3, one of the prominent MPX3 materials, with borocarbonitride (BCN), for hydrogen evolution reaction (HER). The piled up nanosheets of FePS3 and BCN are held together by an electrostatic force, and display extreme robustness under the harsh conditions of HER application. The amalgamated electrocatalyst achieved an overpotential of 187 mV at a current density of 10 mA cm-2 with a shallow Tafel slope of 41 mV dec-1, following the Volmer-Heyrovsky mechanism. The resilience of the electrocatalyst has been examined through chronoamperometric testing for long term stability, and it is stable for more than 14 hours, which shows the excellent electrocatalytic activity for hydrogen evolution reaction owing to the strategic approach to the catalyst design, the use of numerous electrochemically active sites, large surface area and a barrier-free channel for quick ion transfer.

Alginate-CaCO3 hybrid colloidal hydrogel with tunable physicochemical properties for cell growth

Biomaterials composed of food polysaccharides are of great interest for future biomedical applications due to their great biocompatibility, tunable mechanical properties, and complex architectural designs that play a crucial role in the modulation of cell adhesion and proliferation. In this work, a facile approach was designed to obtain novel 3D alginate-CaCO3 hybrid hydrogel particles in situ. Controlling the gel concentration from 3 to 20 mg·mL−1 allows us to control the alginate-CaCO3 hydrogel particles' size and density (size variation from 1.86 to 2.34 mm and density from 1.22 to 1.29 mg/mm3). This variable also has a considerable influence on the mineralization process resulting in CaCO3 particles with varied sizes and amounts within the hydrogel beads. The measurements of Young's modulus showed that the inclusion of CaCO3 particles into the alginate hydrogel improved its mechanical properties, and Young's modulus of these hybrid hydrogel particles had a linear relationship with alginate content and hydrogel particle size. Cell experiments indicated that alginate-CaCO3 hybrid hydrogel particles can support osteoblastic cell proliferation and growth. In particular, the amount of hydroxyapatite deposition on the cell membrane significantly increased after the treatment of cells with hybrid hydrogel particles, up to 20-fold. This work offers a strategy for constructing inorganic particle-doped polysaccharide hybrid hydrogel scaffolds that provide the potential to support cell growth.

Inclusion Bodies in Ionic Liquids

The pivotal role of proteins in pharmaceuticals is challenged by stability issues, making the study of inclusion bodies—a source of insoluble protein aggregates—increasingly relevant. This review outlines the critical procedures in inclusion body processing, focusing on ’mild solubilization concepts’ and refolding methodologies. Attention is afforded to the emerging role of ionic liquids with unique and tunable physicochemical properties in optimizing protein unfolding and refolding processes. The review critically assesses the existing literature at the intersection of inclusion bodies and ionic liquids, identifying recent advancements, potential applications, and avenues for future research. This comprehensive analysis aims to elucidate the complexities in efficient protein processing from inclusion bodies.

Thickness‐Dependence of 2D g‐C3N4 Artificial Interface Layers on Lithium Metal Deposition

AbstractConstructing artificial interfacial layers using 2D materials with tunable physicochemical properties is a promising strategy to fabricate high‐performance lithium (Li) metal anodes. However, their structural evolution during solid‐electrolyte interphase (SEI) formation and the thickness effects on charge transport remain elusive. Herein, 2D g‐C3N4 layers with varied thicknesses are developed on the surface of copper foil to evaluate the thickness effects of artificial SEI on Li metal deposition. It is demonstrated that a thin g‐C3N4 layer (≈2 nm) is rapidly decomposed and fractured under the impact of Li‐ion flux, while a thick g‐C3N4 layer (≈50 nm) impedes the transport of lithium ions and electrons simultaneously, hindering the Li metal deposition underneath. Notably, a g‐C3N4 layer with moderate thickness (≈10 nm) dominates in‐situ generation of stable g‐C3N4/Li3N hybrid artificial SEI and enables fast Li‐ion transport, which induces uniform Li deposition. The lithium electrode protected by the moderate‐thickness g‐C3N4 layer exhibits outstanding cycling stability with a high average Coulombic efficiency of ≈98.92% for over 380 cycles and enables stable cycling of full cell with 50% Li excess and lean electrolyte. This proof‐of‐concept study provides essential guidance for the application of 2D materials in constructing artificial SEI for Li metal anodes.

The Emerging Landscape for Combating Resistance Associated with Energy-Based Therapies via Nanomedicine.

Cancer represents a serious disease with significant implications for public health, imposing substantial economic burden and negative societal consequences. Compared to conventional cancer treatments, such as surgery and chemotherapy, energy-based therapies (ET) based on athermal and thermal ablation provide distinct advantages, including minimally invasive procedures and rapid postoperative recovery. Nevertheless, due to the complex pathophysiology of many solid tumors, the therapeutic effectiveness of ET is often limited. Nanotechnology offers unique opportunities by enabling facile material designs, tunable physicochemical properties, and excellent biocompatibility, thereby further augmenting the outcomes of ET. Numerous nanomaterials have demonstrated the ability to overcome intrinsic therapeutic resistance associated with ET, leading to improved antitumor responses. This comprehensive review systematically summarizes the underlying mechanisms of ET-associated resistance (ETR) and highlights representative applications of nanoplatforms used to mitigate ETR. Overall, this review emphasizes the recent advances in the field and presents a detailed account of novel nanomaterial designs in combating ETR, along with efforts aimed at facilitating their clinical translation.