AbstractMicrofluidics has achieved a paradigm-shifting advancement in life sciences, automation, thermal management, and various other engineering streams. In recent years, a considerable amount of research has been conducted on the use of microfluidics in designing novel systems and fabricating next-generation smart materials that are capable of outperforming historical barriers and achieving unprecedented qualities. One such innovative development is the integration of fluidics into building artificially structured smart materials called acoustic metamaterials to achieve active tunability for a real-time controllable manipulation of acoustic waves. Leveraging the capability of microfluidics to automate the manipulation of liquid droplets, fluid streams, or bubbles in a required arrangement has revolutionised the development of actively tunable fluidics-integrated acoustic metamaterials for widescale applications. This review first discusses the prominent microfluidic actuation mechanisms used in the literature to develop fluidics-integrated smart acoustic metamaterials, and then it details integrated metamaterial design and extraordinary applications such as active acoustic wave manipulation or building tunable acoustic holograms etc. The following review concludes by providing the importance and future perspective of integrating microfluidic techniques with novel metamaterial designs, paving the way for innovative futuristic applications.