Tumors Of Uterine Cervix Research Articles

Imaging in Uterine Cervix Tumors

Imaging in Uterine Cervix Tumors

CLINICOPATHOLOGICAL STUDY OF NEOPLASTIC LESIONS OF UTERINE CERVIX AT A TERTIARY CARE CENTRE

Background:- Cervical cancer is the second most common cancer of women in India and most common cause of death among women in developing countries. HPV infection has emerged as the important causative agent in development of carcinoma cervix. Cervical screening program has drastically reduced rates of carcinoma cervix in developed countries. Present study is being conducted to study the spectrum of neoplastic cervical lesions and its association with clinical presentation in different age groups. The present prospective Material And Methods: study was performed on all the biopsies and specimens of cervix received in the Pathology department. Total 356 cases were studied, out Results:- of which 264 cases were neoplastic, 75 cases were non neoplastic, and 17 cases were pre neoplastic lesions. Maximum number of cases seen in 5th decade, multiparous, with bleeding as most common presentation. Squamous cell carcinoma was the predominant neoplastic lesion. Conclusion:- In our study, majority of cases were multiparous commonly presented in 5th decade of life. Neoplasms of uterine cervix include a wide range of lesions, most predominant being squamous cell carcinoma, It is essential to spread awareness for strengthening of screening programmes at early age for early diagnosis and treatment.

Merger and Consolidation-Carcinosarcoma-Uterine Cervix

Carcinosarcoma of uterine cervix is an exceptionally encountered, high grade neoplasm composed of malignant epithelial and mesenchymal elements. Additionally designated as malignant mixed mesodermal tumour, homologous neoplasms of uterine cervix are denominated as carcinosarcoma.

Pancreatic metastases from uterine cervix tumors – diagnostic challenge and therapeutic options

Pancreatic metastases represent rare eventualities, being more frequently encountered in colorectal, ovarian or breast cancer, other primaries being usually reported more often in autopsy studies. When it comes to cervical cancer, it usually is responsible for the development of local recurrences, lymphatic recurrences or hematogenous metastases in lungs. The aim if the current paper is to discuss about the possibility of developing pancreatic metastases from cervical cancer and to analyze the most efficient therapeutic strategies in such cases.

Use of ginger to control nausea and vomiting caused by chemotherapy in patients with cervical cancer undergoing treatment: An experiment.

Introduction:Uterine cervix tumors have an invasive nature, with the capacity to proliferate to surrounding organs such as the vagina, bladder, and rectum, as well as the capacity for dissemination and involvement of structures distant from its place of origin. According to the International Federation of Gynecology and Obstetrics, patients with stages IB I, IB I microscopic (small dimension <4 cm) are indicated for radiotherapy or adjuvant chemoradiotherapy with cisplatin (40 mg/m2). However, cisplatin has side effects such as hematological implications (anemia, neutropenia, and thrombocytopenia), gastrointestinal disorders (nausea, vomiting, diarrhea, constipation), and fatigue. Zingiber officinale contains bioactive compounds that act on pregnancy and postoperative nausea, chemotherapy-induced nausea and vomiting, and also in the management of fatigue, myalgia, and insomnia. This study aimed to evaluate the effects of ginger on chemotherapy-induced nausea and vomiting in patients with cervical cancer undergoing treatment with cisplatin and radiotherapy.Methods and analyses:A randomized intervention clinical and controlled trial with a triple-blind design is described, comparing the effects of institutional antiemetic therapy alone, as well as in combination with 2 different ginger concentrations.Ethics and dissemination:Due to the nature of the study, we obtained approval from the Division Ethics Committee of Liga Contra o Câncer. All participants signed an informed consent form prior to randomization. The results of this study will be published in peer-reviewed journals. The data collected will also be available in a public repository of data.Trial registration number:This study is registered in the Brazilian Registry of Clinical Trials under number RBR-47yx6p9. This study was approved by the Division Ethics Committee of Liga Contra o Câncer under CAAE 40602320.0.0000.5293.

Assessment of epigenetic alterations and in silico analysis of mutation affecting PTEN expression among Indian cervical cancer patients.

Genetic and epigenetic anomalies accountable for genetic dysregulation are the most common aberrations that determine the underlying heterogeneity of the tumor cells. Currently, phosphatase and tensin homolog (PTEN) incongruity has emerged as potent and persuasive malfunctioning in varied human malignancies. In this study, we have analysed the promoter hypermethylation and expression status of PTEN. We identified different mutations in the exonic region of PTEN. Functional consequences of these mutations were explored using in silico techniques. Promoter hypermethylation of PTEN was detected using methylation-specific polymerase chain reaction (MS-PCR), expression analysis was performed with immunohistochemistry (IHC) and mutation by direct sequencing in a total of 168 uterine cervix tumor cases. The findings were statistically correlated with the clinical parameters. In addition, the effect of nonsynonymous mutations was studied with molecular dynamics simulations. PTEN promoter hypermethylation (45.8%) was found to be significantly associated with the of PTEN loss (57.14%, P < 0.0001). Tumor stages, tumor size, lymph node (LN) were found to be significantly correlated with both PTEN promoter hypermethylation and PTEN loss. Histological grade, however, showed a significant association with only PTEN loss. In total, 11.76% of tumors exhibited mutations in exon 5 and 7, out of which E150K of exon 5 showed the highest deviations in the crystal structure of PTEN by in silico analysis. This study provides valuable insights into oncology and paves the path in the development of efficient biomarker and/or imperative therapeutic tool for cervical cancer treatment.

Cervical Abnormalities and Gynecological Neoplasms in Heart Transplanted Recipients

Purpose Cervical cancer is the most common gynecological cancer worlwide. Squamous intraepithelial lesions (SIL) are known precursors for carcinoma of uterine cervix and associated to infection by human papillomavirus (HPV). Several studies have shown an increased risk of malignant anogenital lesions in recipients of kidney and liver transplants compared to the general population, but there is less information in heart transplanted recipient Methods We conducted a retrospective unicentric study to analyze the prevalence of cervical abnormalities and gynecological neoplasms in cardiac transplant recipients Results From 1984 to 2017, 557 transplants were performed. 124 recipients were female. A total of 242 tumors have been registered in 129 patients. Of the 242 tumors 61% were cutaneous, 8% lymphoproliferative and 31% (75) were solid organ tumors. Of the 75 solid organ tumors, 19 have occurred in women; 3 were breast neoplasms and 10 were genital tumors; 2 located in the vulva and 8 SIL. The age of the recipients was 36 ± 14 years, all of them affected by non-ischemic cardiomyopathy (2 hypertrophic, 1 lupus cardiomyopathy, 1 congenital heart disease and 6 dilated cardiomyopathies). Time from the transplant to the diagnosis of the tumor was 79 ± 33 months. In 6 of the 8 patients with SIL concomitant HPV infection was confirmed, in the remaining two this information was not available Conclusion In our serie, in female recipients of heart transplantation gynecological tumors represent 68% of solid organ tumors. SIL are the main gynecological tumor. Taking in account the association of SIL with HPV infection, vaccination of patients who are candidates for a heart transplant would be beneficial in the prevention of uterine cervix neoplasms

The spectrum of neoplasms of uterine cervix and their clinico-morphological correlation in tertiary care center in dakshina Karnataka

Introduction: Cervical carcinoma is one of the leading causes of death among women worldwide. An estimated of 2,30,000 women die annually from cervical cancer, and almost 1,90,000 are from developing countries. It is considered to be the 3rd most common malignancy among women. Materials and Methods: This is a 5 year retrospective study done in the department of pathology, Kasturba medical college, Manipal. Hysterectomy and cervical biopsies are included in this study. Clinical details were obtained from case sheets. Results: 175 cases of cervical neoplasms were studied in total. The patient’s age was ranged 21 to 80 years with mean being 50.5 years. Among the commonest complaints was post-menopausal bleeding followed by menorrhagia and intermenstrual spotting. 49% cases had a growth in the cervix followed by 12% cases with induration and 10% cases as polyp in cervix. Among the 175 cases, 14.86% cases were precursor lesions. Among the malignant cases, squamous cell carcinomas (61.71%) were the commonest. Rare tumour includes 2.86% cases of minimally invasive carcinoma, 1.71% cases of neuroendocrine carcinoma, and 1.14% cases each of serous carcinoma. Conclusion: Neoplastic lesions from the uterine cervix comprise of a wide variety of lesions originating from both the epithelial and stromal elements. Among the malignant tumours, squamous cell carcinoma was very common. Hence, a thorough clinical evaluation and post-menopausal health check-ups along with detailed cervical examination and microscopic evaluation is the key towards correct and timely diagnosis of cervical neoplasms.

Biomarker for Radiation Therapy: The Relationship Between Tissue Oxygenation and Redox Status

Tumor hypoxia is prognostic for poor response to cancer therapy. The prognostic value of tumor hypoxia has been demonstrated in radiotherapy studies of human head and neck and uterine cervix tumors, which show that patients with less hypoxic tumors had a better chance of overall or disease-free survival than did patients with more hypoxic tumors. Furthermore, some chemotherapeutic agents such as bleomycin and doxorubicin exhibit a cytotoxicity that is strongly oxygen dependent, suggesting that hypoxia may be a prognostic factor for chemotherapeutic response as well. Therefore, development of methods allowing measurement of hypoxia in human patients may allow physicians to better manage tumors that exhibit considerable hypoxia. The recent development of a bi-modality magnetic resonance imaging/electron paramagnetic resonance imaging (MRI/EPRI) platform has enabled longitudinal monitoring of both tumor oxygenation and redox status in murine cancer models. The current study used this imaging platform to test the hypothesis that a more reducing tumor microenvironment accompanies the development of tumor hypoxia. To test this, the redox status of the tumor was measured using Tempol as a redox-sensitive MRI contrast agent, and tumor hypoxia was measured with Oxo63, which is an oxygen-sensitive EPRI spin probe. Images were acquired every 1-2 days in mice bearing SCCVII tumors. The median pO2 decreased from 14 mmHg at 7 days after tumor implantation to 7 mmHg at 15 days after implantation. Additionally, the hypoxic fraction, defined as the percentage of the tumor that exhibited a pO2<10 mmHg, increased with tumor size (from 10% at 500 mm3 to 60% at 3,500 mm3). The rate of Tempol reduction increased as a function of tumor volume (0.4 min-1 at 500 mm3 to 1.7 min-1 at 3,500 mm3), suggesting that the tumor microenvironment became more reduced as the tumor grew. The results show that rapid Tempol reduction correlates with decreased tumor oxygenation, and that the Tempol decay rate constant may be a surrogate marker for tumor hypoxia. Nitroxides such as Tempol may provide a clinically feasible magnetic resonance imaging based assay of hypoxia for radiotherapy.

HDliveFlow with HDlive Silhouette Mode for Diagnosis of Malignant Tumors of Uterine Cervix

ABSTRACT Objective To present our experience of using HDliveFlow with the HDlive silhouette mode to assess malignant tumors of the uterine cervix. Materials and methods Five women with malignant tumors of the uterine cervix (one case each of malignant lymphoma, cervical cancer stage IIA, and three of cervical cancer stage IVb) were studied using HDliveFlow with the HDlive silhouette mode. Results In a case of malignant lymphoma of the cervix, HDliveFlow with the HDlive silhouette mode demonstrated a markedly hyper-vascularized uterus with numerous vessels radiating out from the periphery of the uterus to its center (radialvascular pattern). In four cases of advanced cervical cancer (one case each of stage IIA, and three of stage IVb), HDliveFlow with the HDlive silhouette mode revealed a central hyper-vascular tumor within the peripheral vascular-ring appearance of the cervix, and clearly demonstrated the configuration of the tumor. Conclusion HDliveFlow with the HDlive silhouette mode may provide useful information on the diagnosis of malignant tumors of the uterine cervix. How to cite this article Tanaka T, AboEllail MAM, Ishimura M, Yamamoto K, Ishibashi M, Mori N, Kanenishi K, Hata T. HDliveFlow with HDlive Silhouette Mode for Diagnosis of Malignant Tumors of Uterine Cervix. Donald School J Ultrasound Obstet Gynecol 2016;10(4):409-412.

Cervical Leiomyosarcoma: A Case Report

Introduction: Sarcoma of the cervix is uncommon and its prevalence is about 1% of malignancies of the cervix. One type of sarcoma is leiomyosarcoma and the location of this tumor in cervix is very rare. Although uterine sarcoma can involve the cervix and lead to misdiagnosis of cervical leiomyosarcoma, the location of the bulk of the tumor in uterine cervix (not isthmus) for diagnosis of cer- vical leiomyosarcoma is mandatory. The origin of sarcoma is from mesodermal tissue. Due to the rarity of cervical leiomyosarcoma and response to debulking surgery after recurrence, report of this case is interesting. Case Presentation: We hereby report on a 34-year-old unmarried patient, who was a known case of leiomyosarcoma of uterine cervix that was referred with recurrence of tumor in parietal peritoneum, retropobic retzius space and around the bladder and ureter and sigmoid colon. The patient was treated with debulking surgery of the tumor and chemotherapy. Conclusions: Sarcoma as a genital tract malignancy is very rare and the location of sarcoma at pediatric age is in the vagina and at middle age is in the cervix and at postmenopausal women in the uterine corpus. Cervical sarcoma as a rare tumor of the cervix arises from stromal tissue. Due to hematogenous spread of sarcoma, metastasis in lungs is seen and recurrence of this tumor is not uncommon. In this article, recurrence of a known case with leiomyosarcoma of uterine cervix in previous hysterectomy that responded to debulking surgery with removal of metastatic lesions in peritoneal and retroperitoneal spaces and adjuvant therapy with standard chemotherapy drugs and monoclonal antibody therapy is reported. Due to non-hormonal dependence of sarcoma to hormonal secretion from the ovaries and benefit of the ovaries in young women for protection of bone health and cardiovascular system, oophorectomy is a challenging idea and an issue of debate, thus primary surgery, in this case oophorectomy, was not done.

Laser autofluorescence polarimetry of optically anisotropic structures of biological tissues in cancer diagnostics

The results of a new physical study of polarization manifestations of laser autofluorescence of optically anisotropic structures in human female reproductive tissues are presented. A Mueller-matrix model of describing the complex anisotropy (linear and circular birefringence, linear and circular dichroism) of such biological layers is proposed. Interrelations between mechanisms of optical anisotropy and polarization manifestations of laser autofluorescence of histological layers of the uterine cervix tissue in different spectral regions are determined. Magnitudes and variation ranges of statistical moments from the first to the fourth order describing the distributions of azimuthally stable elements of Mueller matrices of autofluorescence in human female reproductive tissues in different physiological states are found. The informative value of the proposed method is determined and the differentiation of histological biopsy sections of benign (dysplasia) and malignant (adenocarcinoma) uterine cervix tumors is implemented for the first time.

Diagnostic value of quantitative parameters of dynamic contrast-enhanced MRI in the evaluation of different pathological grades of cervical squamous cell carcinoma

Objective To investigate the value of dynamic contrast-enhanced MRI parameters in the diagnosis of cervical squamous cell carcinoma. Methods A retrospective analysis of dynamic contrast enhanced MRI in 55 patients with pathologically diagnosed cervical squamous cell carcinoma without prior treatment. They were divided into three groups based on grade of differentiation: well differentiated(6 patients),moderately differentiated(28 patients)and poorly differentiated group(21 patients). Capacity volume transfer constant (Ktrans),exchange rate constant(Kep) and extravascular extracellular volume fraction(Ve) were measured in each group of patients, and comparing the correlation with ANOVA, DCE-MRI parameters and grading of squamous differentiation using Spearman rank correlation analysis. Results Ktrans of the poorly, moderately and well differentiated cervical squamous cell carcinoma were (2.42±0.58),(1.71± 0.78),(1.27±0.78)/min respectively, Kep were (4.17±1.23), (3.08±1.58), (2.55±0.87)/min respectively, Ve were 0.60 ± 0.12,0.60 ± 0.19, 0.43 ± 0.17 respectively. Statistical difference of Ktransand Kep were found among the subgroups of different pathological grading.(F values were 7.518 and 4.234,P all 0.05). Statistical difference of Ktransand Kep were seen in multiple comparisons, between the groups of poorly and moderately differentiated groups poorly and well differentiated groups (P all 0.05). There were moderate negative correlation between Ktrans,Kep and the pathological degree (r=-0.531 and-0.446, P=0.001and0.002) , Ve had no correlation between pathological grade (r=-0.220, P = 0.141). Conclusion DCE-MRI parameters Ktrans and Kep reveal perfusion characteristics in different pathological grades of cervical squamous cell carcinoma. Key words: Uterine cervix neoplasms; Magnetic resonance imaging

Metastatic endobronchial adenocarcinoma from the uterine cervix verified by human papillomavirus genotyping.

Endobronchial metastasis is defined by bronchoscopically visible extrapulmonary tumors with lesions histologically identical to the primary tumors. Carcinomas of the breast, kidney, and colorectum are the most commonly encountered solid tumors causing endobronchial metastases [1], whereas such metastases arising from the tumors of uterine cervix are relatively rare. While there have been many case reports on endobronchial metastasis of uterine cervical squamous cell carcinoma, there is only one reported case of metastatic endobronchial adenocarcinoma from the uterine cervix [2] and this report focused only on endoscopic treatment. Herein, we report a case of metastatic endobronchial adenocarcinoma from the uterine cervix with discuss on the differential diagnosis.

Radical surgical approach for synchronous ovarian and uterine cervix tumor with uterine cervix liver metastasis

Synchronous ovarian and uterine cervix malignancies are extremely rare gynecologic neoplasia. In the meantime the presence of hepatic metastases originating from cervical cancer is another rare situation, the liver being more often a common site of metastases for ovarian malignancies. We present the case of a 63-year-old patient who was diagnosed with a moderately differentiated squamous cell cervical tumor with urinary bladder invasion associated with an ovarian tumorand liver metastases. An anterior exenteration and atypical liver resection were performed; the histopathological studies revealed the presence of a moderately differentiated squamous cell uterine cervix carcinoma and a well differentiated serous epithelial ovarian adenocarcinoma; the histopathological examination of the liver lesions confirmed the presence of a squamous cell type originating from the uterine cervix neoplasm.

Breast and cervical cancer in patients with systemic lupus erythematosus

To study the incidence of tumors in a Brazilian sample of women with systemic lupus erythematosus. This is a retrospective study of 395 medical charts from women with systemic lupus erythematosus diagnosed by the presence of at least 4 of the American College of Rheumatology classification criteria for the diagnosis of this disease and followed for the last 10 years in a rheumatology outpatient clinic. Demographic data (age and ethnicity of patients), data on disease duration, use of immunomodulators and on the presence of neoplasms were listed. Results are presented in frequency and contingency tables. The incidence rate of malignancies in women with lupus was compared with that of the general population for the same demographic region for the past ten years, using data published by the Brazilian National Cancer Institute (INCA). Association studies were carried out by the Fisher and χ(2) tests, when the data were nominal, and by Mann-Whitney test, when numeric. The level of significance was set at 5%. Twenty-two cases of malignant tumors were identified during these 10 years of follow-up (22 cases/395 or 5.5% of the sample), being the most common those of the uterine cervix (10 cases/395 or 2.5% of the sample) and breast cancer (9 cases/395 or 2.2% of the sample). The presence of tumors was associated with disease duration (p=0.006) and was not influenced by treatment with methotrexate (p=0.1), azathioprine (p=0.9), cyclophosphamide (p=0.6) and glucocorticoids (p=0.3). Breast and uterine cervix tumors were more common in systemic lupus erythematosus women than in the general population (p<0.0001 for both). A high prevalence of malignant tumors was found in this sample, with tumors being more common in patients with longer disease duration. The most frequent tumors affected the breast and uterus at a higher incidence than in the general population. The presence of tumors was not influenced by the use of glucocorticoids or immunosuppressors.

Forkhead box protein P1 is a useful marker for the diagnosis of mucinous minimal deviation adenocarcinoma of uterine cervix.

Mucinous minimal deviation adenocarcinoma (MDA) is a rare highly differentiated tumor of uterine cervix, of which the confusing histopathology resembling some benign lesions usually makes difficulty for pathologic diagnosis. The expression of forkhead box protein P1 (FOXP1) is found in some kinds of human tumors and is considered to be associated with the progression of the tumors. The purpose of this study is to detect the FOXP1 expression in MDA and evaluate its possible role in the diagnosis of MDA. Twenty-two MDA cases and 20 control cases consisting of 10 cases of lobular endocervical glandular hyperplasia and 10 cases of normal endocervical tissue were included in this study. All available clinical data were collected and immunostaining for FOXP1, carcinoembryonic antigen (CEA), human milk fat globule antigen 1 (HMFG1), estrogen receptor, and progesterone receptor were performed on these cases. The nuclear/cytoplasmic expression of FOXP1 was found in 18 of 22 MDA cases while in 1 of 20 control cases, which showed statistical significance (P = .000). The cytoplasmic CEA expression was found in 14 of 22 MDA cases and 2 of 20 control cases (P = .000), whereas cytoplasmic HMFG1 expression was found in 10 of 22 MDA cases and 4 of 20 control cases (P = .081). No statistical difference was found between FOXP1 and CEA expression (P = .083) or between FOXP1 and HMFG1 expression (P = .375) in MDA. Neither estrogen receptor nor PR expression was found in MDA. The significant expression of FOXP1 in MDA may be helpful to some extent in the pathologic diagnosis of cervical MDA. A widened observation range and further researches are needed to elucidate the potential mechanism.

Primitive neuroectodermal tumour of uterine cervix – a diagnostic and therapeutic dilemma

Primitive neuroectodermal tumour, a subgroup of small round cell tumours, was first described by Arthur Purdy Stout in 1918 in relation to the ulnar nerve. Since then, there has been remarkable evo...

Neuroendocrine tumor of the uterine cervix: a clinicopathologic study of 14 cases

The study explored the clinicopathologic characteristics of the neuroendocrine tumor of uterine cervix (NTUC). The general information and the clinical-pathological characteristics of 14 NTUC cases were reviewed. The median age of the cases was 41 years. Six cases (42.9 %) were FIGO stage Ib1, four cases (28.6 %) were Ib2, one case was IIa2 (7.1 %), one case (7.1 %) was IIb, one case (7.1 %) was IIIb and one case (7.1 %) was IVb. Radical hysterectomy and bilateral salpingo-oophorotomy plus pelvic lymphadenectomy were performed on seven cases: three cases had radical hysterectomy plus pelvic lymphadenectomy; one case had transabdominal hysterectomy; and one case had a residual cervical resection. Four cases had positive pelvic lymph nodes. Two cases (14.3 %) had the tumor infiltrated to the parametrium and five cases (35.7 %) to lymphovascular space. One case had positive margin of vagina. Nine cases (64.3 %) were administered post-surgery radiotherapy and all cases were given adjuvant chemotherapy. The median follow-up time was 10 months. The median disease-free survival was 6 months, and the median total survival time was 18 months. The median estimated survival time was 32.0 months (95 % CI 16.9-47.1 months). NTUC is a very rare malignant tumor of female genital tract. Multi-center cooperation to gather more cases is the best method to explore the biological behavior and for the proper treatment of NTUC.

Neuroendocrine tumors of uterine cervix in Mexican women.

e15569 Background: Neuroendocrine tumors of the uterine cervix are rare, aggressive, and carry a poor prognosis. Most are small cell (SCNEC) and large cell (LCNEC). The limited knowledge of this neoplasm is based on small series due to the rarity of the diagnosis.There is a lack of information about NEC in Latin America. We describe both demographic and clinical characteristic of Mexican patients; and their multidisciplinary management in a reference center. Methods: We studied retrospectively clinical and histopathological variables of 33 women treated at the National Cancer Institute of Mexico from 1991 to 2010 with NEC. Patients were allocated into groups according to staging (Group 1 FIGO stages IB1 and IB2; Group 2 IIA-IVA, and Group 3 IVB). Results: Mean age at diagnosis was 50 y.o.; mean tumour size was 4.9 cm. There were 59.4% SCNEC and 40.6% LCNEC. Stage at diagnosis: IB1 15% (n=5), IB2 3% (n=1), IIA 18.2% (n=6), IIB 27.3% (n=9), IIIA 6% (n=2), IVB 27.3% (n=9). Common sites of metastases were lung and liver. The most common presenting symptom was transvaginal bleeding. In Group 1, 6/7 patients received multimodal management with surgery, chemoradiotherapy and induction or adjuvant chemotherapy. In Group 2, 12/17 patients received three modalities, 3/17 received only 2, due to comorbidty. In Group 3, 8/9 received 2 modalities. Patients with one treatment modality were those with disease progression. Cisplatin was used concurrently with radiotherapy; paclitaxel and carboplatin or etoposide and cisplatin were used for either induction or adjuvant settings. Disease free survival in months was: 50.3 (group 1); 23.1 (group 2), and 3.5 (group 3). Overall survival was: 68.5, 46.3, and 17.2 months, respectively. Main sites of recurrence were pelvis, mediastinum, lung, liver, central nervous system, pancreas, adrenal gland, bone and soft tissue. Conclusions: TheNational Cancer Institute of Mexico offers multidisciplinary treatment emphasizing local control after systemic therapy in both early and locally advanced disease; providing the most favourable disease-free survival and overall survival described. To our knowledge, this is the first report of NEC in the Mexican population, where carcinoma of uterine cervix represents yet an important public health issue.